Treatment The goal of treatment is correction
of the hyperglycemic, hyperosmolar state.
The upshot: A 20 % carb diet meets the body's glucose needs without much risk
of hyperglycemic toxicity even in diabetics.
In my reply to Jimmy Moore's safe starches symposium (see Jimmy Moore's seminar on «safe starches»: My reply, Oct 12), I didn't quite have time to fully address the issue
of hyperglycemic toxicity.
As J Stanton commented, it would have been good to note that we recommend consuming «safe starches» as parts of meals, not as isolated snacks, and to discuss how meal design mitigates risk
of hyperglycemic toxicity:
Adoptive transfer of these cells resulted in reversion
of the hyperglycemic state in NOD mice, with reduced T cell infiltrates in the pancreas and increased circulating FoxP3 + regulatory T cells.
The percentage
of hyperglycemic animals increased progressively with time after inoculation of Tg pancreas extracts, whereas up to 20 wk of age, no animals of the Tg / WT group reached the threshold to be considered hyperglycemic.
Not exact matches
A simple explanation
of this procedure, called
hyperglycemic (high blood sugar), hyperinsulinemic (high insulin), or euglycemic (normal blood sugar) glucose clamps, can be found at this link: https://www.diabeteshealth.com/whats-a-glucose-clamp-anyway/
In a study published in Nature Communications, the investigators report that
hyperglycemic mice (or mice with type 2 diabetes) have a 24-fold higher accumulation
of succinate, an intermediate metabolite, in the metabolic pathways
of their bone marrow stromal cells.
«In our study, the
hyperglycemic mice had increased bone resorption [the breakdown and absorption
of old bone], which outpaced the formation
of new bone.
In the study, «Succinate and its G - protein - coupled receptor stimulate osteoclastogenesis,» the researchers took samples
of bone marrow from
hyperglycemic male mice and healthy mice.
Because prior studies have shown that
hyperglycemic patients also exhibit elevated nasal glucose levels, it is likely that the sweet taste receptor function we demonstrate here may also contribute to the predisposition
of diabetic patients to airway infections.»
These results confirmed the sensitivity to estrogen
of pancreatic alpha cells, which then secrete less
hyperglycemic glucagon, but more GLP1.
In a chronic sleep deprivation experiment, young mice were sensitized to insulin and had improved control
of their blood sugar, whereas aged animals became
hyperglycemic and failed to maintain appropriate plasma insulin concentrations.
Indeed, the percentage
of severely
hyperglycemic animals was clearly higher in the group
of Tg - hIAPP treated with synthetic aggregates, reaching 36 % at 16 wk old, whereas none
of the controls showed high glycemia at that time (Fig. 7 B).
Otherwise
hyperglycemic parents beget diabetic offspring, further contributing to pandemic increase
of T2DM.
Their protective effects were attributed, in part, to the avoidance
of postprandial
hyperglycemic peaks (4, 5) because recurrent postprandial hyperglycemia results in overproduction
of reactive free radical molecules and greater release
of inflammatory cytokines (4, 6).
It prevents
hyperglycemic toxicity to neurons, pancreatic cells, the arterial walls and the generation
of excessive levels
of reactive oxygen species.
22 AGEs have been shown to induce lipid peroxidation, so exposure
of fragile membrane PUFAs to a
hyperglycemic environment can be considered toxic.
Nevertheless, just as a fever spiking too high can create problems
of its own, increasing numbers and density
of Aβ plaques in a
hyperglycemic brain can initiate chain reactions
of glycation and oxidation that serve to exacerbate mitochondrial dysfunction, decreased ATP production, and cognitive decline.
Some important studies include: • Beneficial effects
of a high carbohydrate, high fiber diet on
hyperglycemic diabetic men (1976) • Response
of non-insulin-dependent diabetic patients to an intensive program
of diet and exercise (1982) • Diet and exercise in the treatment
of NIDDM: The need for early emphasis (1994) • Toward improved management
of NIDDM: A randomized, controlled, pilot intervention using a low fat, vegetarian diet (1999) • The effects
of a low - fat, plant - based dietary intervention on body weight, metabolism, and insulin sensitivity (2005) • A low - fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes (2006) • A low - fat vegan diet and a conventional diabetes diet in the treatment
of type 2 diabetes: a randomized, controlled, 74 - wk clinical trial (2009) • Vegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with Type 2 diabetes (2011) • Glycemic and cardiovascular parameters improved in type 2 diabetes with the high nutrient density (HND) diet (2012)
At 8 months
of age, both DIO and DR groups had increased
hyperglycemic response during a glucose tolerance test, which was normalized in 16 - month - old mice.
1935 Effects
of the high carbohydrate - low calorie diet upon carbohydrate tolerance in diabetes mellitus 1955 Low - fat diet and therapeutic doses
of insulin in diabetes mellitus 1958 Effect
of rice diet on diabetes mellitus associated with vascular disease 1976 Beneficial effects
of a high carbohydrate, high fiber diet on
hyperglycemic diabetic men 1977 Effect
of carbohydrate restriction and high carbohydrates diets on men with chemical diabetes 1979 High - carbohydrate, high - fiber diets for insulin - treated men with diabetes mellitus 1981 High carbohydrate high in fibre diet in diabetes 1982 Response
of non-insulin-dependent diabetic patients to an intensive program
of diet and exercise 1983 Long - term use
of a high - complex - carbohydrate, high - fiber, low - fat diet and exercise in the treatment
of NIDDM patients 1994 Diet and exercise in the treatment
of NIDDM: the need for early emphasis 1999 Toward improved management
of NIDDM: A randomized, controlled, pilot intervention using a lowfat, vegetarian diet 2005 The effects
of a low - fat, plant - based dietary intervention on body weight, metabolism, and insulin sensitivity 2006 A low - fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes 2006 Effect
of short ‐ term Pritikin diet therapy on the metabolic syndrome 2009 A low - fat vegan diet and a conventional diabetes diet in the treatment
of type 2 diabetes: a randomized, controlled, 74 - wk clinical trial
I would say non-overweight women who consume a high amount
of carbohydrates expose their child to a
hyperglycemic environment.
Kiehm TG, Anderson JW, Ward K. Beneficial effects
of a high carbohydrate, high fiber diet on
hyperglycemic diabetic men.
al Hader, A. A., Hasan, Z. A., and Aqel, M. B.
Hyperglycemic and insulin release inhibitory effects
of Rosmarinus officinalis.
Goals
of management include correcting fluid deficits and electrolyte balance associated with severe dehydration, reducing blood glucose via insulin therapy, correcting the
hyperglycemic, hyperosmolar state, and managing concurrent diseases.
Hyperglycemic Hyperosmolar Nonketotic (HHNK) Syndrome: An uncommon complication
of undiagnosed or unregulated diabetes, HHNK occurs when your cat's blood sugar rises so high that urine is produced at a higher rate than the cat can drink water.