Sentences with phrase «of hyperinsulinaemia»

Dr. Donnelly from the University of Nottinghmam, UK writes, «The findings could also be interpreted as indicating that insulin and sulphonylureas are equally harmful in the obese, possibly as a consequence of hyperinsulinaemia».

The consequent effect of hyperinsulinaemia on fetal development has already been shown.

Not exact matches

One theory proposes that once the storage capacity of subcutaneous adipose tissue (SAT) depots is exceeded under conditions of energy excess, either as a result of impaired expandability and / or excessive hypertrophic growth, fat deposition within visceral depots and non-adipose tissues including the liver, skeletal muscle and pancreas can ensue.93 This can subsequently lead to the development of systemic IR and a series of associated cardiometabolic disorders including dyslipidaemia, dysglycaemia, hyperinsulinaemia and hypertension.3 Expression of pro-inflammatory mediators including interleukins 1 (IL - 1), 6 (IL - 6), tumour necrosis factor alpha (TNF - α) and resistin, are also increased which can further potentiate IR and promote atherosclerosis.

According to the «Twin Cycle Hypothesis», chronic energy excess (in the presence of skeletal muscle IR) results in a compensatory hyperinsulinaemia in an attempt to maintain normoglycemia, however will also promote the accumulation of intrahepatic lipid (IHCL) via the stimulation ofde novo lipogenesis.

Some of this relates to insulin but some to high blood glucose itself; and there's also an interplay between insulin and sex hormone regulation that means low carb diets are beneficial for PCOS, which is a fertility problem related to hyperinsulinaemia.

Suggested treatments include those that reduce insulin resistance / hyperinsulinaemia, such as lifestyle modifications (exercise, diet and weight loss) and pharmacological treatments that include the administration of thiazolidinediones or metformin.

Furthermore, high blood levels of insulin can act by increasing androgenous hormonal stimulation of the ovarian theca cells as well as potentiating gonadotropin - stimulated ovarian androgen steroidogenesis — although recent data has suggested that the insulin - induced increase in ovarian hormone secretion is not accompanied by increased steroid metabolism.74 Hyperinsulinaemia may also affect the central actions of androgen by impairing progesterone inhibition of the gonadotropin - releasing hormone pulse generator.75 Insulin has also been shown to increase expression of adrenal steroidogenic enzyme mRNA47 as well as adrenal responsiveness to adrenocorticotropic hormone.76