Not exact matches
Dogs with mutations in both copies
of the SLC2A9 gene are predisposed to have elevated levels
of uric acid in the urine, hence the name
hyperuricosuria.
Because
of this mutation, Dalmatians are susceptible to
hyperuricosuria and formation
of urinary calculi that can obstruct the urinary tract (a life threating complication) and which may require surgical removal.
The records
of this laboratory show that English bulldog owners ordered 2482 tests involving coat color between 2012 and 2016 compared to 62 tests involving the
hyperuricosuria mutation.
The
hyperuricosuria is not the only cause
of urate urolithiasis, and conditions such as portosystemic shunts and hepatic microvascular dysplasia also may predispose dogs to this disease.
Karmi N, Safra N, Young A, Bannasch D, Validation
of a urine test and characterization
of the putative genetic mutation for
hyperuricosuria in Bulldogs and Black Russian Terriers.
Researchers at the University
of California at Davis studied
hyperuricosuria and found that breeds more likely to inherit the tendency for this condition include Dalmatians (males especially), Bulldogs, and Black Russian Terriers.
To demonstrate the power
of across breed mapping, three positive control traits,
hyperuricosuria, white spotting and chondrodysplasia, were selected for genome wide association analysis.