Sentences with phrase «of hypocretin»

Sporadic cases can happen in any breed and is caused by a loss of hypocretin 1 - producing neurons in the hypothalamus.

they may need leptin infusions to offset the loss of hypocretin neurons in the hypothalamus from years of damage.

Moreover, some recent complicated neurobiological work done on mice has shown that injecting them with leptin decreases the activity of their Hypocretin Neurons.

One notable source of excitation is corticotrophin releasing hormone, which suggests that stress activates the activity of Hypocretin Neurons.

Symptoms appear only after more than 90 % of the hypocretin - producing neurons have been destroyed.

Spinal fluid from living narcoleptics also has revealed an almost complete absence of hypocretin.

The laboratory aims are to advance the understanding of the implication of the hypocretin system in cocaine - and alcohol - seeking behavior.

Patients lose certain brain cells in the hypothalamus, leading to a deficiency of hypocretin, a molecule that helps regulate the sleep - wake cycle.

Meanwhile, pharmaceutical companies are racing to design new narcolepsy drugs based on the discovery of hypocretin's central role in the disorder.

Not exact matches

The hypocretin receptor 2 gene could be the single most important gene in human narcolepsy, says Michael Aldrich, a neurologist and director of the University of Michigan's Sleep Disorders Center.

Hypocretin — which binds to hypocretin receptor 2 — is manufactured in large quantities in some parts of the hypothalamus, an area known to be important in regulatHypocretin — which binds to hypocretin receptor 2 — is manufactured in large quantities in some parts of the hypothalamus, an area known to be important in regulathypocretin receptor 2 — is manufactured in large quantities in some parts of the hypothalamus, an area known to be important in regulating sleep.

Think of brain cells as rooms with locks called receptors on their surfaces and a hypocretin as a key that is also a stimulant.

Researchers have engineered the genomes of mice so they have a light - sensitive inhibitory molecule that can shut down the wakefulness - promoting properties of neurons called hypocretin cells.

Their search turned up a suspect: a piece of a receptor for hypocretin resembles part of the H1N1 influenza nucleoprotein — which binds to the virus genome and plays a key role in its replication.

The result indicates that T cells and HLA, which together regulate much of the body's immune response, gang up in a unique way to destroy narcoleptics» hypocretin cells, the team reports online this week in Nature Genetics.

Although later studies found no further evidence of an immune link, the coincidence made Mignot and many other sleep researchers suspect that an autoimmune attack was ravaging narcoleptics» hypocretin - producing cells.

Hypocretin (orexin) facilitates reward by attenuating the anti-reward effects of its co-transmitter dynorphin.

Now a test of his spinal fluid showed a complete lack of the hormone hypocretin, which regulates wakefulness.

In late 2013, he published what seemed to be a breakthrough study of patients with narcolepsy, which identified self - reactive T - cells that pursued the hormone hypocretin.

For example, orexin / hypocretin levels increase during sleep loss (39) and orexin / hypocretin neurons are an important component of sleep — wakefulness and feeding neural systems (40, 41).

Orexin / hypocretin: A neuropeptide at the interface of sleep, energy homeostasis, and reward system

Hypocretin Neurons play the role both of trigger and of accelerator, taking states of wakefulness, insomnia, stress, and obesity into continual positive feedback loops.

Hypocretin Neurons upregulate the production of molecules down several other pathways, too: these include noradrenergic, histaminergic, cholinergic, dopamine, and serotonergic.

From there, Hypocretin Neurons project to all regions of the brain, including the hypothalamus, cerebral cortex, brain stem, and spinal cord.

Hypocretin Neurons may serve as one of the answers to the question of exactly how that phenomenon comes about.

It seems as though Hypocretin Neurons may act as a nexus of signal input for the appropriate synchronization of various autonomic, endocrine, and metabolic processes.

Because 1) Hypocretins simultaneously stimulate appetite and wakefulness, particularly through orexigenic output of the melanocortin system, and subsequent release of CRH, which activates the stress response, and 2) while Hypocretin Neurons wake us up, they also need to be quiet enough for people to go to sleep.

I have also personally experienced metabolic distress as a result of fasting, which is evidenced by my interest in hypocretin neurons.

What this means is that Hypocretin Neuron activity is stimulated in part by decreasing levels of leptin in the blood, and that increased leptin levels reduce the level of excitation running through Hypocretin Neurons.

Norepinephrine and orexin (also called hypocretin) keep some parts of the brain active while we are awake.