The bone marrow should respond to anemia by producing more red blood cells; therefore, an increase in the number
of immature cells called reticulocytes should be seen on lab results.
The intestinal lining of people with Crohn's disease and IBS (irritable bowel syndrome) appear to be more sensitive to the effects of food lectins because the lining is constantly being replaced by new tissue that is made up
of immature cells that are more glycosylated and thus more susceptible to lectin attachment.
If a woman has an abortion, she's left with a large number
of these immature cells lining her breast ducts, and she is therefore more vulnerable to cancer down the road — 30 percent more vulnerable, Brind says, than a woman who has never had an abortion.
Not exact matches
«We suspected that the young are most vulnerable because
of their
immature immune systems, but we didn't have a lot
of hard evidence to show that before,» said study lead author Bo Hang, a Berkeley Lab staff scientist who previously found that thirdhand smoke could lead to genetic mutations in human
cells.
A newborn has more red blood
cells than his body needs, and often, when a baby's
immature liver can't process them quickly enough, a yellow pigment called bilirubin (a by - product
of the red blood
cells) builds up in the blood.
Consistent with this idea, microscopic examination
of fetal small intestine before birth reveals
immature epithelium and sparse lymphoid
cells.
What's more, the live
cells in breast milk that protect babies from infection can be even more important for premature babies: Preemies face a higher risk
of infection because their immune systems are particularly
immature.
Newborns become jaundiced in the first few days because the enzyme in the liver maybe
immature and does a process
of breaking down these red blood
cells as rapidly.
When a
cell is dividing, each anchor point is actually a pair
of centrioles: a mature «mother» centriole, and an
immature «daughter» centriole.
By analysing the early steps that precede tumor formation, Alexandra Van Keymeulen and colleagues found that expression
of oncogenic Pik3ca reactivates a multilineage differentiation program in adult stem
cells that resembles to an
immature embryonic state.
The first complete, real - time recording
of an egg
cell eliminating its centrioles shows the starfish egg
cell handles mature «mother» centrioles (green) differently from
immature «daughter» centrioles (purple).
At fertilization, sperm delivers a structurally distinct genome, along with a complement
of ribonucleic acids, or RNAs, and proteins to the
immature egg
cell.
Immature dendritic
cells (DCs) sequester intact antigens in lysosomes, processing and converting antigens into peptide — MHC II complexes upon induction
of DC maturation.
Smell neurons begin as identical precursor
cells,
immature cells that have not yet «decided» which type
of nerve
cell they will become.
Next, the team exposed
immature immune
cells from the blood
of healthy people to the bacteria found in the guts
of MS patients.
In 1868, however, the German pathologist Ernst Neumann discovered
immature precursor
cells in bone marrow, which turned out to be the actual site
of blood
cell formation, also known as hematopoiesis.
The mice benefited from human stem
cells called glial progenitors,
immature cells poised to become astrocytes and other glia
cells, the supposed support
cells of the brain.
In theory, if a single mutation popped up that caused
immature neurons to undergo just one extra cycle
of cell division, that could double the final size
of the cortex.
The most striking abnormalities were a markedly elevated white blood
cell count
of 28,500 per cubic milliliter (the normal level is about 5,000 to 10,000) and what is called a shift to the left, which refers to a large increase in the number
of mature and
immature granulocytes,
cells that increase in number when an acute infection must be fought off.
They then purified messenger RNA — a molecule that plays a key role in the production
of proteins — from the
cells in the animals» upper intestines, injected the mRNA into
immature eggs
cells, and looked for changes in iron uptake.
His experiments revealed the
cells that became rhabdomyosarcoma were not muscle
cells, but were
immature cells that would mature into
cells lining the inner surface
of blood vessels.
Klingelhutz and his team immortalized
immature precursor fat
cells by adding in two genes from HPV (the virus that causes cervical cancer) along with a gene for part
of an enzyme that controls the length
of cells» telomeres — the pieces
of DNA that protect chromosome tips from deterioration.
Then came a new step: They carefully extracted the fragile,
immature eggs and some surrounding
cells from the follicles, and allowed them to further mature on a special membrane in the presence
of more growth - supporting proteins.
Around the time
of birth these germ
cells have formed a large reserve
of primordial follicles — each containing a single
immature egg.
2006 Shinya Yamanaka identifies and activates a small number
of mouse genes in the
cells of connective tissue, showing they can be reprogrammed to behave like
immature stem
cells.
That ovarian tissue bears clusters
of cells known as primordial follicles, which surround
immature precursors to egg
cells.
ALMOST BRAIN A cross section
of an
immature lab - grown approximation
of a human brain reveals neurons (green) and neuron - producing stem
cells (red).
The human equivalent to the mouse
cells, however, would have to be isolated from fetal retinas, posing the familiar problem
of finding a source for the
immature cells.
The skin's ability to grow back after a wound led scientists to assume that it must contain stem
cells,
immature cells that can rapidly differentiate into many different types
of tissue.
Immature egg
cells begin this way, but are transformed through a process called meiosis into mature egg
cells that only have one copy
of each chromosome.
The human brain consists
of thousands
of different types
of nerve
cells that are all formed out
of what in simple terms can be described as
immature stem
cells.
Most
of the pollen that is likely tickling your nose and making your eyes water is being dispersed in a sexually
immature state consisting
of only two
cells (a body
cell and a reproductive
cell) and is not yet fertile.
Two types
of immature B
cells, namely fetal liver hybridomas and the leukemic
cell line 70Z / 3, both
of which have cytoplasmic mu chains but no light chains, were examined for DNA rearrangements
of their light chain and heavy chain immunoglobulin genes.
Last year, Robin Ali
of University College London and colleagues demonstrated that
immature retina
cells from newborn mice could form rod
cells — a type
of light - gathering
cell — that wire into the retinas
of night - blind adult mice (SN: 5/19/12, p. 13).
For the technology to help restore sight in people, such as those with macular degeneration, the researchers needed to come up with a ready source
of immature retinal
cells.
The results suggest that, although the lack
of light chain synthesis can be due to a lack
of gene rearrangement, there may also be transcriptional regulation, which may also be important for the expression
of light chain immunoglobulins in
immature B
cells.
But the discovery
of vast numbers
of immature eggs dying in the ovaries
of mice led Tilly's team to find what they claim are hidden ovarian stem
cells that can sprout new eggs to replace
«I tend to scrutinize reticulocyte [
immature red blood
cell] values,» Ashenden says, «to see if there are any signs
of accelerated or decelerated reticulocyte production.»
To understand how the bacteria affected the immune system, the researchers grew L. reuteri in liquid and then transferred small amounts
of the liquid — without bacteria — to
immature immune
cells isolated from mice.
As «
immature» somatic
cells, stem
cells can mature into different types
of cells, thus making them responsible for the development
of all the tissues and organs in the body.
Medical researchers have been working to use stem
cells,
immature cells that can develop into various types
of tissue, to regenerate cartilage.
By immersing stem
cells harvested from men's bone marrow in a cocktail
of chemicals that mimic the environment
of the testes, Nayernia and his team turned the stem
cells into
immature sperm.
The researchers tested their technique on such cultivated stem
cells of both a mature and
immature type, and on donated human embryos left over from IVF treatments.
A new type
of pluripotent
cell that genuinely corresponds to the more
immature, pre-implantation stage has been identified and can now be cultivated in the laboratory.
They have screened combinations
of antibodies that bind to specific proteins on the surface
of the
immature and mature stem
cells and that can be used for flow cytometry, a common laboratory technique for sorting
cells.
The green glowing center
of this Arabidopsis root contains a protein that helps transform
immature precursor
cells into some
of the specialized
cells that make up the plant's root tip.
In their latest study, researchers at La Jolla Institute for Allergy and Immunology identified a key signal that drives the commitment
of immature Tfh
cells into fully functional Tfh
cells and thus driving the step - by - step process that results in a precisely tailored and effective immune response.
Immunofluorescence microscopy reveals the different protein profiles
of immature stem
cells (coloured pink) and mature stem
cells (coloured green).
The scaffold supports the survival
of the mouse's
immature egg
cells and the
cells that produce hormones to boost production.
They saw HIV - infected human immune
cells, caught virus particles in the act
of budding from such
cells, and also found groups
of free
immature and mature viruses.