Castration and training in a spatial task alter the number
of immature neurons in the hippocampus of male mice.
To start, the scientists examined previous experiments and identified several transcription factors — managerial proteins that switch on the activity of large sets of genes — that seemed crucial to the ability
of immature neurons to develop into adult sensory neurons.
They found that dendrites in adult mouse brains were studded with long spines, a hallmark
of immature neurons.
Not exact matches
Smell
neurons begin as identical precursor cells,
immature cells that have not yet «decided» which type
of nerve cell they will become.
In theory, if a single mutation popped up that caused
immature neurons to undergo just one extra cycle
of cell division, that could double the final size
of the cortex.
ALMOST BRAIN A cross section
of an
immature lab - grown approximation
of a human brain reveals
neurons (green) and
neuron - producing stem cells (red).
«
Neurons become increasingly more complex in their extensions and connections as the brain matures, and the maturational delays reported previously in animal models and human behavioral studies of iron deficiency would predict that lower iron intake would produce neurons in cortical gray matter that are structurally less complex and more im
Neurons become increasingly more complex in their extensions and connections as the brain matures, and the maturational delays reported previously in animal models and human behavioral studies
of iron deficiency would predict that lower iron intake would produce
neurons in cortical gray matter that are structurally less complex and more im
neurons in cortical gray matter that are structurally less complex and more
immature.
Immature sympathetic
neurons respond to NGF with a burst
of metabolic activity that provides the material necessary for the growth
of the nerve fiber and the manufacture
of molecules
of neurotransmitter.
It is not yet known whether the dramatic and selective effects
of the NGF antibodies are due to a direct toxic action
of the antibodies on
immature sympathetic
neurons or to an inactivation by the antibodies
of circulating molecules
of NGF, thereby indirectly causing the death
of the sympathetic
neurons by depriving them
of the NGF they need in order to survive.
In addition to apparently being essential to the survival
of immature sympathetic
neurons NGF seems to play a vital role in guiding nerve fibers toward their corresponding target organs.
Immature sympathetic
neurons were seeded into the central chamber in the presence
of NGF and allowed to send out growing fibers under the silicon barriers along scratches made on the bottom
of the culture dish.
Shortly after this discovery K. Unsicker and his colleagues at Johns Hopkins University found that
immature chromaffin cells obtained from the medulla (inner part)
of the adrenal gland and cultured in the presence
of NGF acquire the biochemical and morphological properties
of sympathetic
neurons.
Jason Lee / Reuters In the next few months, surgeons in the Chinese city
of Zhengzhou will carefully drill through the skulls
of people with Parkinson's disease and inject 4 million
immature neurons derived from human embryonic stem cells into their brains.
It could also distinguish dead from living cells, spot
neurons within groups
of cells that included astrocytes and
immature dividing cells, and even tell a dendrite from an axon.
Overall, the study found, older and younger brains had similar numbers
of «intermediate» progenitor cells and «
immature»
neurons — signaling that older people had a similar capacity for generating new cells as young people.