Immunofluorescence microscopy reveals the different protein profiles
of immature stem cells (coloured pink) and mature stem cells (coloured green).
Not exact matches
By analysing the early steps that precede tumor formation, Alexandra Van Keymeulen and colleagues found that expression
of oncogenic Pik3ca reactivates a multilineage differentiation program in adult
stem cells that resembles to an
immature embryonic state.
The mice benefited from human
stem cells called glial progenitors,
immature cells poised to become astrocytes and other glia
cells, the supposed support
cells of the brain.
2006 Shinya Yamanaka identifies and activates a small number
of mouse genes in the
cells of connective tissue, showing they can be reprogrammed to behave like
immature stem cells.
ALMOST BRAIN A cross section
of an
immature lab - grown approximation
of a human brain reveals neurons (green) and neuron - producing
stem cells (red).
The skin's ability to grow back after a wound led scientists to assume that it must contain
stem cells,
immature cells that can rapidly differentiate into many different types
of tissue.
The human brain consists
of thousands
of different types
of nerve
cells that are all formed out
of what in simple terms can be described as
immature stem cells.
But the discovery
of vast numbers
of immature eggs dying in the ovaries
of mice led Tilly's team to find what they claim are hidden ovarian
stem cells that can sprout new eggs to replace
As «
immature» somatic
cells,
stem cells can mature into different types
of cells, thus making them responsible for the development
of all the tissues and organs in the body.
Medical researchers have been working to use
stem cells,
immature cells that can develop into various types
of tissue, to regenerate cartilage.
By immersing
stem cells harvested from men's bone marrow in a cocktail
of chemicals that mimic the environment
of the testes, Nayernia and his team turned the
stem cells into
immature sperm.
The researchers tested their technique on such cultivated
stem cells of both a mature and
immature type, and on donated human embryos left over from IVF treatments.
They have screened combinations
of antibodies that bind to specific proteins on the surface
of the
immature and mature
stem cells and that can be used for flow cytometry, a common laboratory technique for sorting
cells.
Bone marrow contains
immature stem cells that can grow into three types
of cells: red blood
cells, to transport oxygen; white blood
cells, for fighting infections; and platelets, to facilitate clotting when needed.
Stem cell scientist Martin Pera of the University of Melbourne in Australia, calls it an «exciting study» that demonstrates that the environment within an adult body can help immature stem cells develop to an adult stage, something that has proven difficult to do in vi
Stem cell scientist Martin Pera
of the University
of Melbourne in Australia, calls it an «exciting study» that demonstrates that the environment within an adult body can help
immature stem cells develop to an adult stage, something that has proven difficult to do in vi
stem cells develop to an adult stage, something that has proven difficult to do in vitro.
Converting adult skin
cells into pluripotent
cells —
immature stem cells that can be programmed to become any tissue in the body — is a rapidly developing area
of science that earned the researcher who discovered the technique, Shinya Yamanaka, a Nobel Prize in 2012.
Jason Lee / Reuters In the next few months, surgeons in the Chinese city
of Zhengzhou will carefully drill through the skulls
of people with Parkinson's disease and inject 4 million
immature neurons derived from human embryonic
stem cells into their brains.
New studies in mice have shown that
immature stem cells that proliferate to form brain tissues can function for at least a year — most
of the life span
of a mouse — and give rise to multiple types
of...
Normally, the bone marrow makes
stem cells (
immature cells) that become three types
of mature blood
cells:
«The fact that fetal
stem cell transplantation has not been very successful has been puzzling, especially given the widely accepted dogma that the
immature fetal immune system can adapt to tolerate foreign substances,» said co-senior author Qizhi Tang, PhD, an assistant professor
of transplant surgery and director
of the UCSF Transplantation Research Lab.
The team identified the connections between rs9349379 and EDN1 by deleting a region
of DNA at the SNP in human pluripotent
stem cells and then converting these
immature cells into endothelial
cells and vascular smooth muscle
cells.
Differentiation
of bCSCs led to an increase in DNA methylation suggesting that the hypomethylated state is characteristic
of immature cancer
cells, similar to that that observed for normal blood and skin
stem cells [3].
Researchers had developed the technologies needed to create organoids years before — how to grow
cells in culture, how to isolate
stem cells from human tissue, and how to coax the
stem cells, undifferentiated and
immature, to become specific types
of cells at later stages
of development.
Surprisingly, by introducing only a few genes, he could reprogram mature
cells to become pluripotent
stem cells, ie
immature cells that are able to develop into all types
of cells in the body.
Salk researchers reprogrammed skins
cells taken from a sickle
cell disease patient into induced pluripotent
stem cells (iPSCs),
immature cells capable
of developing into any type
of bodily tissue.
A major scientific puzzle, said Singh, has been how and why
immature hematopoietic
stem cells initially express genes that are characteristic
of more than one
cell lineage.
Gage and Ghosh discuss how human skin
cells induced to return to an
immature state («induced pluripotent
stem cells» or IPS
cells) are revolutionizing our understanding and treatment
of mental and neurodegenerative disorders, such as Parkinson's disease, as well as leading to new models
of drug development for all diseases.