Sentences with phrase «of immune cell»

Schumacher was the first to develop a technology for high - throughput analysis of immune cell reactivity to cancer neoantigens, which has allowed researchers to better observe the effects of immunotherapy in patients and has made it possible to develop personalized, patient - specific immunotherapies.

Working with a group of 16 cancer survivors, all but one of who recently finished chemotherapy cancer treatment, the researchers focused on T cells, a type of immune cell that attacks a variety of infectious agents as well as cancer cells.

(A) Cellular and molecular mechanisms of immune cell recruitment and activation in inflammatory and metabolic disease.

Agilent Seahorse XF technology is enabling the shift to real - time quantification of immune cell function, opening a new window on controlling cell fate.

However, important hallmarks of immune cell states are often not detected in scRNA - seq experiments.

Today, Rudensky, a Howard Hughes Medical Institute Investigator and professor of immunology at Sloan - Kettering Institute in New York City, counts among the world's foremost immunologists for his discoveries on the molecular architecture of a type of immune cell implicated in autoimmune disorders, inflammatory disease, and cancer.

This video shows an agent - based model of an immune cell receiving chemical signals from other cells.

Additionally, mesenchymal stem cells induce the production of T regulatory cells, a type of immune cell whose function is to protect the body against immunological self - attack.

 Much of transplant biology focuses on one type of immune cell (T cells), but Newell found that the cells that may make the biggest difference for long - term tolerance are different, B cells.

Her aim is to understand, at the molecular level, the mechanisms that control communication between the brain, immune system, and blood vessels — with the ultimate goal of designing new therapies that slow, stop, or reverse the progression of a wide range of neurological disorders, such as MS. Recently, Dr. Akassoglou's lab identified how microglia — a type of immune cell that acts as the brain's first line of defense — are activated when fibrinogen enters the brain or spinal cord.

Older studies have shown that certain compounds can activate iNKT cells in mice by stimulating the response of another type of immune cell called cytokines.

The researchers counted the numbers of a particular type of immune cell, known as microglia, in the samples and found that these were more numerous in the brains with Alzheimer's disease.

Ipilimumab targets a protein called cytotoxic T lymphocytic antigen - 4 (CTLA - 4) that is found on a type of immune cell called a T cell.

It has long been suspected that changes to cells of the monocyte / macrophage lineage, a type of immune cell, influence the development of cognitive impairment in HIV.

HIV - 1 replication requires the coordinated movement of the virus's components toward the plasma membrane of an immune cell, where the virions are assembled and ultimately released.

Dendritic cells usually send out signals that ramp up proliferation of another type of immune cell, T cells, which then attack invaders.

Their study in aged mice indicates that high folic acid intake causes lowered immune function because natural killer (NK) cells, a particular type of immune cell, are less effective.

Rituximab kills off B cells, a type of immune cell implicated in some autoimmune conditions.

Lab tests indicated that resolvins suppress inflammation of monocytes and neutrophils, two types of immune cell.

«Further studies are needed to understand the connections we're uncovering and the roles of these proteins, but we're clearly seeing evidence that these genetic variants have an effect in this type of immune cell.»

In a new study published in Nature Neuroscience this week, researchers in the Ann Romney Center for Neurologic Diseases at Brigham and Women's Hospital (BWH) investigate how genetic risk factors for Alzheimer's disease may influence a key type of immune cell.

Calling it the «big bang» of immune cell development, the researchers made their discovery within previously overlooked stretches of DNA located between genes.

This «friendly fire» goes unchecked due to the failing of another type of immune cell: called the T - reg, which controls T - effector cells, shutting them down when they are not needed.

B cells are a type of immune cell that produce antibodies.

«Icebreaker» protein opens genome for T - cell development, researchers find: Study provides new view of immune cell identity, which can be harnessed to fight cancer, autoimmune disorders, and infectious diseases.»

The researchers then assessed the prevalence of a kind of immune cell called a myeloid cell, which were derived from the donated stem cells in the blood of the recipient mice, at eight and 16 weeks after transplantation.

In the newly published study, Mount Sinai researchers from The Mindich Child Health and Development Institute and the Jaffe Food Allergy Institute report that by counting the numbers of one type of immune cell activated by exposure to a food, a simple, safe blood test can accurately predict the severity of each person's allergic reaction to it.

In the Dec. 1 issue of Science, the team from the MGH Center for Systems Biology describes a «crosstalk» between lung tumors and bone marrow, which leads to the generation of a type of immune cell that travels to the tumor and promotes its progression.

She found that the brain depends on a type of immune cell known as the T cell, which normally kills infected cells or leads other immune cells in a campaign against foreign invaders.

Moffitt researchers wanted to determine if it would be possible to activate the cancer - fighting properties of T cells indirectly by targeting another type of immune cell called a dendritic cell.

«Up until now, researchers have focused on T cells — another type of immune cell,» said John J. O'Shea, M.D., scientific director of NIAMS and senior author of the paper.

However, chronic liver inflammation in both mice and humans also led to the accumulation of immunosuppressive lymphocytes, a type of immune cell Karin and Shalapour first described two years ago.

A few years ago, Chawla's group had reported that cold exposure activated macrophages, a type of immune cell, in white adipose tissue.

Such mice lack a gut microbiome and do not develop this kind of immune cell.

S. mansoni IPSE binds to Immunoglobulin E (IgE), an antibody produced by the immune system that is expressed on the surface of basophils, a type of immune cell; and mast cells, another immune cell that mediates inflammation; and sequesters chemokines, signaling proteins that alert white cells to infection sites.

Upon further investigation, they found that IL - 17 was produced by gamma delta T cells, a type of immune cell found in mucosal tissues.

In experiments in mice, UC San Francisco researchers have discovered that regulatory T cells (Tregs; pronounced «tee - regs»), a type of immune cell generally associated with controlling inflammation, directly trigger stem cells in the skin to promote healthy hair growth.

With the aid of thousands of skin biopsies and over a hundred kilograms of skin, researchers at Karolinska Institutet have observed how two subgroups of immune cell behave in healthy skin.

The researchers also wanted to revisit the Trojan horse hypothesis, to see if, as had been proposed, infected monocytes, a type of immune cell, might be responsible for carrying the parasite into the brain.

Healthy skin is protected against microbial attack by different kinds of immune cell, including T cells.

The same area has a known role in the development of T - cells, a key type of immune cell.

The drug's mechanism of action was entirely new: Instead of attacking cancer cells (like chemo), or indiscriminately revving up the immune system (like IL - 2), ipilimumab blocked a single receptor on one type of immune cell.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

His group focused on another type of immune cell known as primary macrophages and their response to live bacterial pathogens.

«The control of immune cell entry into the joint represents a major point at which new therapies could be developed to reduce the symptoms of inflammatory arthritis,» says Luster, who is the Harrison Professor of Medicine at Harvard Medical School.

A few years ago, MS researchers were focused on a new type of immune cell called the Th - 17 cell, which appeared to be a key player in driving the neuronal damage in MS. Because Th - 17 cells produce the cytokine IL - 17, researchers likewise thought this chemical was essential to the disease.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

Soon he and Janeway discovered a new class of sensor on the surface of a certain kind of immune cell.

USE it or lose it: a class of immune cell demolishes idle circuits and connections in the brain, even a healthy one.

«The ratio of CD4 and another type of immune cell, CD8, which is often abnormally reversed in HIV, normalized.