Sentences with phrase «of immune cell responses»

5 — Immunity Activation: While conventional cancer treatments often suppress immune function, hyperthermia can actually enhance it — through a whole cascade of immune cell responses.

Not exact matches

The initial immune response involves cells of the body's innate immune system, such as macrophages and neutrophils.

In December, SQZ partnered with global pharma firm and cancer treatment leader F. Hoffmann - La Roche in a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and additional sums when SQZ meets certain milestones — to speed up the development of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off cancer.

CRAC channels control the entry of calcium into immune and other cell types, and calcium is an important intracellular signaling molecule that modulates cytokine production and the immune response.

Turnips are high in vitamins A and C; antioxidants that together play an important role in stimulating the body's immune response by boosting the formation of antibodies and white blood cells.

In addition, Red Star Nutritional Yeast contains other beneficial components, such as beta - 1,3 glucan and mannan, complex carbohydrates known to improve the immune response and help maintain cholesterol levels that are already within a healthy range; trehalose, a disaccharide that helps maintain the health of brain cells; and glutathione, an antioxidant that plays an important role in cellular defense mechanisms.

Avoid foods and drinks with lots of sugar as sugar can interfere with immune response (white blood cells) for up to 6 hours after consumption.

CD4 cells (also known as T4 or helper T cells) are lymphocytes (a type of white blood cell), which are important in immune responses.

The introduction of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the response of the infant immune system to pathogens.47 - 51 A greater amount of natural - killer cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, 53

An immune response, triggered by foreign neural stem cells, could actually help attack tumors, says Evan Snyder, a stem cell biologist at Sanford Burnham Prebys Medical Discovery Institute in San Diego, California, and one of the early pioneers of the idea of using stem cells to attack tumors.

The research, published and featured in the Spot Light section of the December edition of the Journal of Virology, examines a previously unknown connection between flaviviruses — a classification of viruses that include West Nile virus, Dengue virus and tick - borne encephalitis virus — and organelles (a specialized subunit within a cell) known as peroxisomes that help coordinate the body's immune responses.

The researchers found that the immune cells in the skin of this animal model generated large amounts of the cytokine IL - 17 — a protein of the immune system that activates cellular inflammation in response to damage.

When the team compared the types of immune cells activated in the fetus with those in the mother, there were clear differences, suggesting that fetuses generate an independent immune response to CMV (Journal of Experimental Medicine, DOI: 10.1084 / jem.20090348).

On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.

«These T - cells dampen incorrect responses of the immune system and have a strong anti-inflammatory effect.

«Similarly, triggering extra production of particular dendritic cells could improve the immune response to infections or vaccines.

The scientists zeroed in on a type of immune cell called regulatory T - cells, which were known to suppress autoimmune responses.

The cells suppress the immune response in the livers of mice, without affecting the rest of the immune system.

They discovered a population of NKT cells that have a gene that controls so - called regulatory T - cells, whose role is to suppress the immune response.

Commenting on the study for ESMO, Dr Olivier Michielin, head of Personalised Analytical Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, said: «Omaveloxolone's novel mechanism of action is to block MDSCs, cells known to suppress the immune response.

Epitopes are displayed on the surface of circulating immune cells and are where T cells bind antigens to fuel the immune response.

«If we learn how to control dendritic cells, we could strengthen our immune response to infection when needed, or weaken the action of certain immune cells that attack the body's own tissues in autoimmune disease.»

Without the regulatory influence of PD - 1, the over activated and over stimulated T cells result in disruption of a crucial balance between different T cell types that leads to an overall greatly reduced immune response.

«While transient disruption of this pathway may have therapeutic benefit because it temporarily «revs up» the immune response, permanent loss of PD - 1 signals seems to result in a «flame out» where T cells can't sustain higher level activation and become more dysfunctional,» Wherry says.

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

Based on these ex vivo experiments (in cells isolated from patients and then exposed to PD - L1 blocking agents outside of the body), they predict that when actual patients are given PD - L1 blocking agents, their viral load at the time will influence the «net» outcome, i.e., whether the blockage boosts or weakens the overall anti-HIV immune response.

Furthermore, the team found that ONA inhibited the pro-tumor functions of myeloid derived suppressor cells (MDSC), which are closely associated with the suppression of the anti-tumor immune response of host lymphocytes, by using preclinical sarcoma model.

NKp46 was critical for the subsequent development of antiviral and antibacterial T cell responses, which suggests that the regulation of NK cell function by NKp46 allows for the optimal development of adaptive immune responses.

That increase inhibited the ability of regulatory T cells to suppress the Th2 immune response in mice.

The molecule regulates genes that suppress immune surveillance mechanisms, including the production of cells that inhibit the immune response.

They focused on the role of monocytes, immune cells that normally pass along the blood vessels and in response to a local infection move quickly into the affected organ and contribute to the localized immune defense there.

The researchers showed that the synapse - eating process requires a protein in the complement system — a part of the immune response that helps «tag» unwanted cells and other debris for destruction.

Loss of LKB1 by regulatory T cells was also associated with increased levels of signaling molecules or cytokines associated with the Th2 immune response, Kai said.

George Klinman, an FDA immunologist and lead author of the report, speculates that dangling the protein in front of the immune system in an unusual setting — on a muscle cell — might be what triggers the inappropriate response.

However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials.

Onion A increases anti-tumor immune response by inhibiting the immune suppression actions of macrophage and myeloid derived suppressor cells (MDSC).

Two different types of dendritic cells in the immune system present antigen in different ways to elicit distinct immune responses.

Wrangle explained that natural killer cells are the chief arm of the innate immune response.

ONA appears to activate anti-tumor immune responses by nullifying the immunosuppressive function of myeloid cells.

Using cells from cadavers, doctors have been experimentally transplanting pancreatic islets into humans for decades, but as many as 60 percent of the transplanted islets die immediately because they are cut off from their blood supply and are killed by an immune response due to direct injection into the bloodstream, and those that survive the transplant usually die within several months.

Now we know how it does this: its active ingredient targets a newly discovered type of cell that lowers the immune response.

Despite having been vaccinated against the disease in 1989, which was 3 years before Sousa and her colleagues examined them, 58 % of the Indians had a weakened or nonexistent immune reaction in skin tests that measure cell response to the tuberculosis bacterium.

«We were fascinated to find that, without the influence of Myb, Treg cells would allow the immune response to spin out of control, resulting in severe inflammation pretty much everywhere — whether in the lungs, liver, intestine or skin,» she said.

Preclinical findings revealed that Myb gives immune cells called regulatory T (Treg) cells the «authority» to control the strength of the immune response depending on the level of «threat», from minor infections to aggressive diseases.

The experiments indicated that when dectin - 1 recognizes tropomyosin in house dust mites, shrimp or other common allergy - triggering species it suppresses airway cells» production of an immune molecule, IL - 33, which otherwise would promote an allergic response by immune cells.

And only 29 % had antibodies that could activate T cells — a necessary part of a strong immune response.

It is the stuff of dreams for flu scientists, but it could be within reach if a new type of vaccine that elicits an immune response from white blood cells is combined with traditional vaccines.

But Acinetobacter also ramped down the production of regulatory T cells, which help prevent autoimmune diseases by dampening the immune response.

Activation of these receptors led to a «massive mobilisation» of myeloid - derived suppressor cells (MDSCs), which play a crucial role in lowering the immune system response back down to normal levels (European Journal of Immunology, DOI: 10.1002 / eji.201040667).

Prompted by studies suggesting immune responses can help repair the nervous system, Kipnis and his colleagues created mice that lack CD4 cells, a kind of T - cell.