Sentences with phrase «of immune checkpoint»

A promising avenue of clinical research in breast cancer is the use of immune checkpoint inhibitors.

A promising avenue of clinical research in kidney cancer is the use of immune checkpoint inhibitors.

In honor of James Allison, Lieping Chen, Gordon Freeman, Tasuku Honjo and Arlene Sharpe for contributions to the pre-clinical foundation and development of immune checkpoint blockade, a novel form of cancer therapy that has transformed the landscape of cancer treatment.

A promising avenue of clinical research in liver cancer is the use of immune checkpoint inhibitors.

A promising avenue of clinical research in colorectal cancer is the use of immune checkpoint inhibitors.

A promising avenue of clinical research in pancreatic cancer is the use of immune checkpoint inhibitors.

Another avenue of clinical research in childhood cancer is the use of immune checkpoint inhibitors.

A promising avenue of clinical research in lymphoma is the use of immune checkpoint inhibitors.

A promising avenue of clinical research in brain cancer is the use of immune checkpoint inhibitors.

A potentially promising avenue of treatment in leukemia is the use of immune checkpoint inhibitors.

A promising avenue of clinical research in head and neck cancer is the use of immune checkpoint inhibitors.

The success of immune checkpoint inhibitors in cancer therapy continues to grow, but a complete understanding of their underlying mechanisms is still lacking.

Ongoing research involves the evaluation of immune checkpoint inhibition in collaboration with the Ludwig / CRI CVC trials network and the pharmaceutical industry.

A promising avenue of clinical research in multiple myeloma is the use of immune checkpoint inhibitors.

For their collective contributions to the pre-clinical foundation and development of immune checkpoint blockade, a novel form of cancer therapy that has transformed the landscape of cancer treatment.

As demonstrated by the breadth of clinical trial involvement shown above, CCIR members are testing the utility of immune checkpoint blockade in lymphoma (shown by Dr. Allison to be effective against melanoma), genetic engineering in cell therapy (e.g., CD19, CXCR2, TGF - β DNR), and TLR agonists or IL - 2 in vaccine formulations as well as some novel combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotype.

«It appears that the CDK4 / 6 inhibitors might be able to sensitize some patients» cancers to the anti-tumor effects of immune checkpoint inhibitors,» the authors state.

AMD3100, alone or in combination with VIC - 008, decreases expression of the immune checkpoint molecule PD - 1 on CD8 T cells, implying that the CXCR4 / CXCR12 pathway modulates PD - 1 expression.

«We are pleased to have obtained the same results in two different laboratories and we look forward to translating these preclinical findings into combination approaches with entinostat to enhance the clinical activity of immune checkpoint inhibition.»

Commenting on the two studies, Baas says that finding a good treatment for mesothelioma has been a challenge for many years and has so far led to many disappointments, so there is a need for investigation into new pathways such as the use of immune checkpoint inhibitors that target the PD - 1 / PD - L1 pathway.

It would involve gene therapy delivered at the time of surgery and systemic delivery of the immune checkpoint inhibitors, such as through IV injection.

«Recent successes in cancer immunotherapy — in the form of immune checkpoint inhibitors and adoptive T cell transfer — demonstrate how activated immune cells can eradicate tumors, but until now we didn't fully appreciate immunosurveillance or the role of adaptive immunity in tumor formation,» said senior author Michael Karin, PhD, Distinguished Professor of Pharmacology and Pathology at UC San Diego School of Medicine.

One phase I trial of an immune checkpoint blockade drug combined with two established targeted therapies yielded 40 - 50 percent response rates among patients with metastatic kidney cancer.

«We wanted to utilize platelets» intrinsic tendencies to accumulate at wounds and to interact with circulating tumor cells, for targeted delivery of immune checkpoint inhibitors» said Gu, «Interestingly, we found the antibody can be promoted to release from activated platelets in the surgical site, due to generation of small platelet - derived microparticles upon the platelet activation.

These results demonstrate the role of a ubiquitin ligase in control of immune checkpoints with concomitant effect on tumor growth.

In this collaboration with Professor Ze'ev Ronai, we characterize the role of a ubiquitin ligase in the regulation of immune checkpoints.

The company is trying to combine and commercialize two very hot technologies — adoptive T - cell therapy and silencing of immune checkpoints by RNAi.

The blockade of immune checkpoints with antibodies (Ab) anti-CTLA-4, anti-PD1 and anti-PD-L1, has given impressive clinical results and manageable safety profiles.

Not exact matches

In the most recent of these reports (in the latest issue of Science), Dr. Jennifer Wargo, a surgeon and research scientist at M.D. Anderson, along with several dozen colleagues at other institutions, reveal that the composition of a patient's gut microbiota can significantly influence whether he or she responds to an immune checkpoint inhibitor — the type of cancer immunotherapy that releases the emergency brakes in the car analogy above.

BMS's drug, ipilimumab (Yervoy), was the first checkpoint inhibitor (a kind of cancer immunotherapy drug that essentially helps the immune system release its brake and go after tumor cells it might normally miss) to get approved in the US in 2011 for melanoma.

Investigators have repeatedly touted the drug as a potential lynchpin in immuno - oncology, focusing on an enzyme that suppresses the immune cells Opdivo and a whole new class of PD - 1 / L1 checkpoints are designed to unleash in an attack on cancer cells.

By administering a complementary antibody, they blocked the function of two such immune checkpoints, whereby different types of endogenous T - cells were activated.

In a retrospective analysis of clinical trial data, they found that melanoma patients with highly aneuploid tumors were less likely to benefit from immune checkpoint blockade therapy than patients whose tumors showed fewer chromosomal disruptions.

«HPV - active tumors have high expression of immunoregulatory genes and therefore may respond to immune checkpoint inhibitor therapy.

Wrangle and Rubinstein's therapy is a combination of a checkpoint drug, nivolumab, with a new and powerful immune stimulation drug, ALT - 803.

One class of immunotherapeutic drugs is known as «checkpoint» inhibitors, as they target checkpoints in immune system regulation to allow the body's natural defenses, such as white blood cells, to more effectively target the cancer.

«While immune checkpoint blockade therapy is effective in many cancers, it has been less successful for this particular form of prostate cancer, which has motivated a search for targeted therapies that overcome this resistance.»

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

In my experience, this marks both the first clinical trial of an approved drug with an effect on survival in advanced melanoma in the adjuvant setting, and, in this same setting, the first to study an immune checkpoint inhibitor in the adjuvant setting.

«Although we found that chemotherapy activated the T cells, the levels of the protein PD - L1 [to which the immune checkpoint molecule PD - 1 binds to disable T cells and prevent them from recognizing and destroying the cancer cells] remained the same or increased.

Since Allison hatched the idea of blocking CTLA - 4, several more immune checkpoints have been identified.

The cancer cells» defense strategy can be overcome by immune checkpoint inhibitor agents, including anti-PD-1 / PD - L1 antibodies, several kinds of which have received fast - track approval from the U.S. Food and Drug Administration (FDA).

The class of medications that he conceived, known as immune checkpoint inhibitors, works counterintuitively: By turning off one of the immune system's built - in safeguards, the inhibitors allow T cells — the system's foot soldiers — to attack tumors more effectively.

In addition to anti-tumor responses, immune checkpoint inhibitors have also been associated with long - term remission in a subset of patients, Gu said.

They are designed to get around one of the ways that cancer protects itself from the immune system: tumors can activate the body's natural protective response from autoimmunity, called a checkpoint, and thereby thwart cytotoxic T cells.

Known as a checkpoint inhibitor, tremelimumab is an investigational monoclonal antibody that «cuts the brakes» of the immune system by targeting cytotoxic T - lymphocyte antigen 4 (CTLA - 4), a protein that can switch off a patient's immune response.

The ultimate goal of Dr Janji's research team is to provide the proof of concept that targeting autophagy could improve the efficacy of current immunotherapies, notably those based on immune checkpoint blockades.

Once again, researchers at Penn's Abramson Cancer Center have extended the reach of the immune system in the fight against metastatic melanoma, this time by combining the checkpoint inhibitor tremelimumab with an anti-CD40 monoclonal antibody drug.

They have identified a «checkpoint» manned by these immune cells that, if barred, can halt the development of the lung inflammation associated with allergies.

Checkpoint inhibitors, which aim to unleash the power of the immune system on tumors, are some of the most impressive new cancer treatments.