FOXP3 mutations causing early - onset insulin - requiring diabetes but without other
features of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
In
cases of immune dysregulation (autoimmune disorders, cancer, psoriasis) it serves to balance the response, therefore decreasing the dangerous over-reaction to our own cells and tissues that is seen in many of these conditions.
There are many possible
sources of immune dysregulation including environmental exposures and psychosocial stress that would indirectly affect the gut but would not originate there.