Sentences with phrase «of immune escape»

Background: Expression of programmed death ligand (PD - L1 / B7 - H1 / CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells.

Not exact matches

Research suggests that about a third of kids are lucky enough to escape trauma, but about a quarter suffer such high doses that it affects brain development, immune and endocrine functioning, and can create mental and physical disease systems that reduce the lifespan by an average of 20 years.

The child, nearly 4, was found to have high levels of HIV in her blood, suggesting that the virus had escaped from immune control.

But cancer cells can escape immune surveillance using a variety of techniques to disguise themselves.

«We hypothesized that individual mutations in viral genes could be expected to have a range of effects on the virus's ability to replicate, to infect new cells and escape the immune system,» Carlson says.

Only viruses that have mutated escape mechanisms from immune pressures are able to survive, but the mutations come at the cost of other aspects of viral fitness, perhaps inhibiting entry into cells or integration into cell DNA.

In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.

In escaping the immune system, the new mutations can inadvertently disrupt this golden binding point, which can be remedied by adding a sugar molecules in the just the part of the hemagglutinin.

She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as mouse models, to look at the protein in diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.

Publishing in Nature, the study reports that genetic alterations affecting a part of the PD - L1 gene increases the production of the protein, allowing cancer cells to escape detection by the immune system.

«This is the first study to illustrate that a structural abnormality in the 3» untranslated region of the PD - L1 gene causes an abnormally high production of PD - L1 protein, consequently aiding cancer immune escape,» says one of the lead authors, Keisuke Kataoka, at Kyoto University.

Then, they treated the dormant cells with a product of the immune system, they found that dormant cells were susceptible to immunotherapy, and that quiescent, but not indolent cancer cells, could not escape from immunotherapy.

Publishing in Nature, a recent study reports that genetic alterations affecting a part of the PD - L1 gene increases the production of the protein, allowing cancer cells to escape detection by the immune system.

Instead, researchers developed a flu vaccine that ensures influenza viruses can't escape the body's first line of defense, a powerful antiviral system that enlists a cadre of immune proteins and cells.

Conversely, the immune system contains triggers to blunt immune responses, and antibodies that block these «off - switch» checkpoints might be able to further reduce the ability of these cancers to escape the immune system.

Researchers at Albert Einstein College of Medicine in New York City wondered if having a gD - 2 component in a vaccine might «mask» other viral particles and allow them to escape immune detection.

A team of scientists from Singapore has discovered new ways in which cancers can escape the body's immune system.

The bacteria hide within human cells called macrophages, escaping the body's own immune defenses and being shielded from many types of antibiotics.

CRI Investigator Gabriel Rabinovich and his team identify a novel strategy mediated by secretion of the sugar - binding protein galectin - 1 that is used by tumors to escape the immune response.

Viruses that escape this checkpoint drain through lymph vessels to local lymph nodes, where it was assumed macrophages finished the job of the innate immune system before specialized adaptive immunity kicked in.

Poggi A, Musso A, Dapino I, Zocchi MR. Mechanisms of tumor escape from immune system: Role of mesenchymal stromal cells.

The transmission of DFT 1 cells is possible because the cell can escape the devil's immune system.

Among his most important accomplishments was the description of a key mechanism by which tumor cells can escape the host immune system.

Phospholipase D facilitates efficient entry of influenza virus, allowing escape from innate immune inhibition.

One of the most intriguing features of MSCs is that they escape immune recognition and can inhibit immune responses 11.

Interestingly, when parental d42m1 sarcoma cells were transplanted into wild - type mice, around 20 % of recipients developed «escape» tumors which evaded immune destruction and progressed (escape clones).

Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD - L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD - L1 blockade.

More recently, we have learned that it is critical to understand the biology of cancer plasticity to identify the mechanisms that allow tumours to resist or escape immune control.

Thus, in a single experiment, the authors demonstrated that (1) CD4 + and CD8 + T - cells were the mediators of immune system rejection of transplanted tumor cells, and (2) d42m1 escape tumors develop from T - cell - dependent selection favoring cells without the spectrin - B2 antigen.

Some of our next steps are to determine the biological process that causes cancer cells to express non-mutated, shared antigens, and the means by which dormant metastases escape immune elimination.

This research will improve understanding of how the body successfully battles infection, and conversely, how pathogens escape the immune system, causing the individual to succumb to disease.

April 17, 2018 - In our efforts to better understand how HIV escapes the effects of the immune system, scientists have discovered a new mechanism that could hold the answer.

This work demonstrated the central role of HLA - B * 27 and HLA - B * 57 in immune control of HIV infection, and of cytotoxic T lymphocyte (CTL) escape in HIV pathogenesis (Goulder et al, AIDS Res Hum Retr, 1996; Goulder et al, Nat Med, 1997).

Some of these randomly generated «escape mutants,» as they are called, would then be selected for survival in succeeding generations of the virus, since they would possess the advantage of being «fitter» — avoiding the body's immune response — than their nonmutated counterparts.

CRI postdoctoral fellow Dr. Haihui Lu at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, is studying some of the unique characteristics that differentiate metastatic cancer cells from primary tumor cells, and specifically aims to understand how these unique characteristics enable breast cancer cells to escape elimination by the immune system.

In this Review, we discuss recent advances in understanding the molecular determinants of influenza virus immune escape, sources of evolutionary selection pressure, population dynamics of influenza viruses and prospects for better influenza virus control.

Here, we review the current state of the art of somatic cancer evolution and mechanisms of immune control and escape.

Cancer cells have developed a number of ways to survive, including ways to escape detection and attack by our immune system, but their ability to respond to viral infections is actually quite limited.

One of these escape mechanisms involves a type of immune cell called myeloid - derived suppressor cells (MDSCs).

There's no doubt that probiotic exposure very early in life — primarily from a vaginal birth and exclusive breastfeeding for the first six months — helps to seal the «open guts» of babies, thereby preventing foreign substances like food particles from escaping through the intestinal wall into the bloodstream and stimulating allergic immune reactions that can last a lifetime.

It also signals a high probability of intestinal permeability, or leaky gut (which allows undigested foods and pathogens to escape into the bloodstream, where they trigger an immune reaction).

Based on this data, researchers concluded that learned helplessness in rats who couldn't escape the shocks must have suppressed the immune response known to fight off cancer cells in tumors of this sort.

But in my case, the babesia symptoms did not show themselves until the lyme, several years post-bite, escaped control of my immune system.

Though not a terribly artful filmmaker, Robertson is good with actors in close - up (even if it is overused) and at allowing his patiently agitating camera to show the grit of dead - end poverty that the brother's gang world represents and Gen needs to escape: a pit of self - destruction populated by bleary - eyed toughs eager to brutalize and immune to hope.

After surviving a virus outbreak that turns people into zombies, a small group of immune survivors escape the island of Banoi and are picked up by the military.

The key ingredients being chicken and brown rice, this food is not only rich in protein but, is a rich source for vitamins and food - fiber Vets recommend this food as it boosts the immune health of the dogs that enable them to escape the threats of the outburst of various ailments.

Research suggests, if the dogs are served with good high protein dog food, regularly and in adequate volumes, the dog will be in the finest state of health that will ensure the solace and well being of the animal, boosting their immune systems that will enable the dogs to escape the attacks of various ailments.

Now the heroes of the story for some reason are immune to the virus and must survive as they make their way to escape from the islands.

Cut off from the rest of the world, only four individuals who strangely find themselves immune to zombification have the power to protect the remaining survivors from the horrors of the island, to discover what's really going on and find a way to escape before their own fatal ends.

Like the bacteria that cause gonorrhea, members of T. pallidum have multiple copies of the gene coding for the proteins that allow them to adhere to human cells — perhaps, as in the case of gonorrhea, these genes allow T. pallidum to alter their surface proteins in order to escape recognition by the immune system.