Sentences with phrase «of immune recognition»

This new marker of senescent cells is recognized by a naturally occurring IgM antibody that belongs to the innate immune system and is likely to be involved in a natural mechanism of immune recognition and clearance of senescent cells.

Michael Pfreundschuh and colleagues Ugur Sahin and Ozlem Türeci at the University of Saarland develop SEREX (SErological analysis of Recombinant cDNA Expression), providing a powerful method to analyze the humoral immune response to intracellular cancer antigens and ushering in the third phase of cancer serology, bringing with it the prospect of providing a comprehensive view of the immune recognition of human cancer.

Not exact matches

Both studies demonstrate that this is a likely path forward to understanding when the immune system will lead to productive recognition of a tumor.

It persists, in large part, due to continual changes in the sequence of amino acid «building blocks» that make up the viral protein hemagglutinin, enabling it to avoid recognition and removal by immune system antibodies.

The key to this approach is minimizing healthy tissue damage while maximizing cancerous tumor destruction of the sort that improves recognition of the tumor by the immune system.

Altering proteins in one part of the virus to achieve a certain benefit, such as more efficient gene transfer or reduced recognition by host immune cells, could end up destroying the structural integrity of the entire shell.

«Thus PTX3 is recognized as the soluble arm of a pattern recognition receptor, an essential part of innate immune system that recognizes pathogens.

Across kingdoms there exists a range of pattern recognition systems that have become integral to the evolution of innate immune responses.

In volunteers who received a BCG vaccination, she observed an increase in cytokine production (proteins that control immune cells) and in the number of receptors that play a role during the recognition of intruders.

A world first study revealing the presence of two antibodies in a sub-group of children experiencing their first episode of psychosis affirms a longstanding recognition that auto - immune disorders play a significant role in psychiatric illness.

Whilst such studies provide a reservoir of genes involved in bacterial recognition and degradation in vitro the situation in vivo where hemocytes can interact with other immune cells to optimize immune responses is likely to be more complex.

Using a range of chemical and biological methods, the researchers discovered that this social fluid contains a diverse array of chemicals, including growth -, digestion -, and immune - related proteins; nest mate recognition cues; and a juvenile hormone, important for regulating ant reproduction, development, and behavior.

Since T cells can only recognize neoantigens that are «presented» to them by HLA molecules of the immune system, a key step in making the vaccine is using computer algorithms to predict which neoantigen peptides will bind strongly to the HLA molecules for recognition by T cells.

He specifically proposed that evolutionarily conserved features of infectious organisms (pathogen - associated molecular patterns or PAMPs) were detected by the immune system through a set of specialized receptors (which he termed pattern - recognition receptors or PRRs), an especially prescient aspect of this hypothesis.

Stetson, D. B. & Medzhitov, R. Recognition of cytosolic DNA activates an IRF3 - dependent innate immune response.

Without such activation by recognition of infection, Janeway suggested that the adaptive immune system ignored or even became tolerant to the antigens presented by the «quiescent» DC.

Rabbit monoclonals provide better antigen recognition because the rabbit immune system generates antibody diversity, and optimizes affinity by mechanisms that are more efficient than those of mice and other rodents.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2).

Recently, the crucial involvement of IRFs in innate and adaptive immune responses has been gaining much attention, particularly with the discovery of their role in immunoregulation by Toll - like receptors and other pattern - recognition receptors.

Immuno - oncology, as the name implies, recruits the immune system into the battle against cancer, either by boosting its existing but latent anti-tumor responses or honing its recognition of malignant cells.

Self - recognition of the endothelium enables regulatory T - cell trafficking and defines the kinetics of immune regulation.

Innate immune recognition and response to cell death Kenneth RockUniversity of Massachusetts, USA 19th March 201804:15 pm Host: Falko Apel, MPIIB, Berlin Location: Max Planck Institute for Infection Biology, Seminar room 1/2 - Campus Charité Mitte

One of the most intriguing features of MSCs is that they escape immune recognition and can inhibit immune responses 11.

The current efforts of her laboratory are focused primarily on four areas of innate immunity: the molecular basis of pathogen recognition; innate immunity to malaria; Type I interferon gene regulation; and counter regulation of innate immune recognition.

We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host - cell transformation, and a Theileria - specific protein domain [frequently associated in Theileria (FAINT)-RSB- present in a large number of secreted proteins.

The laboratory focuses on understanding the mechanism of peptide selection for immune recognition by major histocompatibility complex (MHC) molecules.

Her current work utilizes flow cytometry to study peptide recognition in the context of the HIV - 1 immune response.

While it is not straightforward to directly compare the immune repertoire reported here with previous reports that have used different underlying gene models [15], [34], we do note that our inference about the number and identity of signaling components is consistent with previous annotations [15], [34], while our inference about recognition and effectors tends to reflect greater, albeit still relatively minor, differences.

«For instance, efforts to block the infection - enhancing activity of these semen amyloids for STD prevention must now consider the potential effects of such interventions on sperm quality and immune recognition of male antigens.»

We propose that the immune system can discriminate between pathogens and the microbiota through recognition of symbiotic bacterial molecules in a process that engenders commensal colonization.

This position, funded by Cancer Research UK, will explore whether manipulation of a novel antigen presentation checkpoint can enhance the repertoire of tumour antigens presented for immune recognition.

Whitehead Institute researchers have uncovered a novel association between two fungal recognition receptors on the surface of certain immune cells, called macrophages.

Previous research from the laboratory of Dan S. Kaufman at the Stem Cell Institute, University of Minnesota, USA has demonstrated that large numbers of Natural Killer (NK) immune cells with potent anti-HIV activity [1] can be derived from hESCs and iPSCs [2, 3], although they lack antigen specific recognition receptors [4, 5].

The method could actually protect mice from a lethal vaginal dose of HSV - 2 without causing immune recognition of the siRNA.5 However, neither of these methods was effective at transducing the T cells that HIV infects; we are still testing ways to modify siRNAs that could prevent HIV transmission, with some promising leads.

Collectively, their work has elucidated foundational mechanisms in cancer's ability to evade immune recognition and, in doing so, has profoundly altered the understanding of disease development and treatment.

It is also recognition of the many investigators who have labored for decades to realize the promise of the immune system in treating cancer.»

recognition that the power of healing diets to help manage illness is real and makes sense given that almost any dietary compound acts on the gut microbiome and that has profound effects of the immune system

Antibodies are long, branched molecules that have places for recognition and binding (attachment) of the antigen on one side, and a site on the other end that can call into action other immune responses.

Yet despite the pervasive integration of technology into various social institutions, one dimension of civil society — the courtroom — has remained relatively immune from technology's noisy demands for recognition.

Like the bacteria that cause gonorrhea, members of T. pallidum have multiple copies of the gene coding for the proteins that allow them to adhere to human cells — perhaps, as in the case of gonorrhea, these genes allow T. pallidum to alter their surface proteins in order to escape recognition by the immune system.