Sentences with phrase «of immune resistance»
There are a variety of mechanisms of immune resistance that operate in the tumor.
https://www.sciencedaily.com/ Not exact matches
AIDS: Acquired immune deficiency syndrome, a disease in which there is a severe loss of the body's cellular immunity, greatly lowering the resistance to infection and malignancy.
Though it might seem a good idea to keep babies away from the harmful environment, it is wrong because it inhibits their ability to develop their own natural resistance and immune thus increasing their tendency of catching allergies and rendering antibacterial treatments less effective when they fall ill.
A study found that as many as 80 percent of the bugs are immune to insecticides in over-the-counter shampoos, and resistance will only increase.
«While immune checkpoint blockade therapy is effective in many cancers, it has been less successful for this particular form of prostate cancer, which has motivated a search for targeted therapies that overcome this resistance.»
«We believe that some of the classes of contaminants that are now in the environment, such as these endocrine disruptors coming out of sewage treatment plants, are having an impact on the immune function in fish and altering disease resistance,» Winton says.
Researchers targeting colorectal cancer stem cells — the root cause of disease, resistance to treatment and relapse — have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.
Increasing cell wall - associated GAG in A. nidulans enhanced resistance to NETs and increased the virulence of this species to the same level as A. fumigatus in immune - compromised mice with intact NET formation.
The findings of these trials improve our general knowledge of the immune system of plants, and in particular of fungal disease resistance of wheat.
Many people develop an immune resistance to these infused factors, but relief may be on the way in the form of anti-inhibitory pills made from plants.
In the iron - poor environment of the human body, where the iron concentration is about one atom per 1.6 liters of blood, initially susceptible P. aeruginosa might find it difficult to develop resistance to pyocin and resistant P. aeruginosa might grow so slowly the immune system would be able to clear them, Inglis said.
Researchers have long tied type 2 diabetes to chronic inflammation, caused by a ramping - up of immune system activity that ultimately damages insulin receptor signalling and leads to insulin resistance.
Epidemiologists worry that the combination of HIV - burdened immune systems and total drug resistance could put TB on the fast track to causing an uncontrollable epidemic.
The immune activation from the CAR cells was also met with resistance mechanisms, including an upregulation of immunosuppressive pathways which may work against the patient and for the tumor, the researchers found.
They say more research is needed to understand whether this level of virus suppression would be enough to halt disease transmission, and they are working on other experiments to see if they can produce antiviral factors in the gut, which could assist in inducing a stronger immune response and possibly confer resistance to the other viruses.
And while new therapies have been effective in releasing the immune system's restraints to unleash the body's own cancer - fighting powers, they only work in about half of melanoma patients and often lose their potency as the cancer develops resistance.
Results of an initial study of tumors from patients with lung cancer or head and neck cancer suggest that the widespread acquired resistance to immunotherapy drugs known as checkpoint inhibitors may be due to the elimination of certain genetic mutations needed to enable the immune system to recognize and attack malignant cells.
«Cancers evade immunotherapy by «discarding the evidence» of tumor - specific mutations: Discovery could explain widespread acquired resistance among patients treated with immune checkpoint blockade drugs.»
Groundbreaking findings, published online in the journal journal Cancer Cell, show that resistance to many types of antibody drugs can be overcome by preventing cancer cells from «hiding» from immune cells.
Resistance to treatment can originate from many sources — the immune system, the complex landscape of a tumor, or a patient's own genes.
They also stressed that IL - 6's role in inflammation «extends well beyond the immune system and the kidney, with high levels of expression in atherosclerotic plaques and elevated serum levels being associated with increased coronary artery disease and morbidity from hypertension, left ventricular hypertrophy, and development of insulin resistance.»
The idea to check the role of the bacterium associated with innate immune signaling in chemotherapy resistance was linked to earlier work done by this researcher team.
In contrast, in mice with normal immune systems, emulsifiers induced low - grade or mild intestinal inflammation and metabolic syndrome, characterized by increased levels of food consumption, obesity, hyperglycemia and insulin resistance.
«We have previously demonstrated the role of MDSCs as important mediators of resistance to immune therapy approaches.
«Natural killer cells help to drive inflammation, insulin resistance: Study in mouse models of diabetes identifies key immune mechanisms in abdominal fat.»
Researchers at Joslin Diabetes Center now have pinpointed a major inflammatory role for «natural killer» (NK) immune cells in abdominal fat — a type of tissue strongly implicated in insulin resistance.
Although reducing the levels of these cells could be problematic due to their role in handling infections, he explains that the immune system generally works quite differently for the regulation of insulin resistance in obesity than it does for combating infections.
Lee and his colleagues believe that NK cells help to regulate insulin resistance by releasing signaling proteins that affect the behavior of macrophages, another kind of immune cells.
Rather, he holds that weight accelerates the action of two other variables: some children's genetic tendency to develop insulin resistance in response to increased weight and some children's genetic tendency to have a highly reactive immune system.
Pre-print: Isolation of a natural DNA virus of Drosophila melanogaster, and characterisation of host resistance and immune responses — William H Palmer — bioRxiv
Regulation of growth, intestinal microbiota, non-specific immune response and disease resistance of sea cucumber Apostichopus japonicus (Selenka) in biofloc systems — Jinghua Chen — Fish & Shellfish Immunology
«We're very interested in following up by finding more direct proof that if you block the recruitment of immune cells to tumors, you can reverse this phenomenon in these animals with endothelial cell insulin resistance,» Rask - Madsen says.
CRISPR - Cas is a molecular immune system that confers resistance to foreign genetic elements, and provides a form of acquired immunity.
Our PDX models and other next - generation cancer modeling platforms allow you to address critical questions in oncology research, such as unexplained drug resistance, drug efficacy, genomic heterogeneity in solid tumor, and the role of the immune system in drug response.
The JCVI GCID aims to study pathogens and the genetic determinants of their virulence, drug - resistance, immune evasion and interactions with the host, and host microbiome to advance research in pathogenicity, drug - resistance, disease transmission and vaccine development.
Aleksandra Walczak: «Diversity and selection in the immune system» Ville Mustonen: «Methods to study and combat the evolution of drug resistance» Peter Arndt: «Modelling neutral evolution of DNA»...
Scientists from the Sundrud lab have identified a normally small subset of immune cells that may play a major role in the development of Crohn's disease as well as steroid resistance associated with the disease.
Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?
The awards span the broad mission of the NIH and include groundbreaking research, such as engineering immune cells producing drugs at the site of diseased tissue; developing a sensor to rapidly detect antibiotic resistance of a bacterial infection; understanding how certain parasites evade host detection by continually changing their surface proteins; and developing implants that run off the electricity generated from the motion of a beating the heart.
Also, you won't find the phenomenon of resistance with immune - based therapies.
These genes typically encode immune receptors that recognize specific protein components of the fungal pathogen to trigger resistance.
Scientists have harnessed this natural ability in order to create vaccines, which use dead or weaker strains of viruses to prime the immune system and stimulate long - term resistance without causing the actual infection.
With their deep expertise in the biology of senescent cells, the Campisi lab will be focused on fundamental research into questions like how senescent cells vary in their susceptibility and resistance to immune clearance (depending on factors like their tissues of residence or the pathway that led them into senescence); the targets and mechanisms used by NK cells to clear senescent cells; and why subsets of senescent cells might persist when their similarly - situated neighbors are cleared out (and what might allow us to overcome that resistance).
She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.
While investigating the side effects of antibiotics and how bacteria can develop resistance to them, researchers from MIT and Harvard have found that the drugs can actually work against the body, weakening the immune system's ability to fight off the bugs.
The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut of plant and animal host - pathogen interactions, host immune responses, characterization and evolution of virulence determinants, cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine targets, as well as aspects of prion diseases and of fungal and protozoan biology.
Another really important one is TNF alpha, which actually itself can induce insulin resistance, and it's involved in regulating immune function as well, so as well as a number of others, but today we'll focus on the leptin itself.
Recent studies have reported that GLP - 1 improves the function of renal endothelial cells (which regulate blood clotting, immune response and blood vessel activity, among other critical functions, and are impaired by insulin resistance) and can prevent some renal pathologies in diabetic rodents.
11/6/2007 UCSD Researchers Discover Inflammation, Not Obesity, Cause of Insulin Resistance Findings may have important potential for new drug discoveries in fight against Type 2 diabetes Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that inflammation provoked by immune cells called macrop... More...
Led by Christiana Davis, MD, (in collaboration with Dr. Peter Gabriel, Chief Oncology Informatics Officer and Abigail Doucette, MPH, Research Registry Program Manager), the Thoracic TCE has established project - based databases to track the demographics and response status of patients to immune - oncology treatments, as well as acquired resistance to standard therapies and novel targeted immunotherapies.