Sentences with phrase «of immunopathology»

BSI member Professor Michael Dustin, explains, «While an overwhelming T - cell response might on the face of it sound effective, it brings risks of immunopathology, where an over-active immune system destroys healthy human tissue, not just the invading disease - causing pathogen.

The vaccines were evaluated for immunogenicity and efficacy; however, because of the previous report of immunopathology on challenge of ferrets and nonhuman primates that had been vaccinated with a whole virus adjuvanted vaccine and mice that had been vaccinated with a VLP vaccine, the primary orientation was to assess for immunopathology among animals in relation to type of vaccine, dosage, serum antibody responses, and virus infection.

Additionally, a more intense study for virus replication including quantitative RT - PCR assays might have confirmed the probability that virus replication is required for induction of the immunopathology after vaccination.

Finally, a number of other studies of vaccines in animal model systems have been reported but presence or absence of immunopathology after challenge was not reported.

The scientific advisory board also includes Douglas Cole, MD, General Partner, Flagship Ventures; Kenneth Chien, MD, Ph.D., professor in the Department of Cell and Molecular Biology and Department of Medicine at the Karolinska Institute, and visiting professor in the Department of Stem Cell and Regenerative Biology, Harvard University.; David Liu, Ph.D., Professor of Chemistry and Chemical Biology at Harvard University, a Howard Hughes Medical Institute Investigator and a Senior Associate Member of the Broad Institute of Harvard and MIT; Douglas Melton, Ph.D., Thomas Dudley Cabot Professor in the Natural Sciences at Harvard University and an Investigator of the Howard Hughes Medical Institute; Elizabeth Nabel, MD, President of the Brigham and Women's Hospital (BWH) and Professor of Medicine, Harvard Medical School; and Ulrich H. von Andrian, M.D., Mallinckrodt Professor of Immunopathology at Harvard Medical School.

Research programs of Immunopathology Unit aim to dissect the cellular and molecular mechanisms responsible for immunopathological responses of the liver, with emphasis on the responses that occur during infection with hepatitis B virus (HBV).

Not exact matches

Having discovered the crucial role of IL - 27 in regulating immunopathology, the researchers wondered whether this could be exploited for therapeutic purposes.

They found that IL - 27 levels in infected lungs follow, with some delay, the level of virus: they peak as viral levels are starting to decline and come down when immunopathology has resolved.

The scientists conclude that in mice «well - timed treatment with rIL - 27 improved lung injury and accelerated recovery without affecting viral clearance» and continue «these data demonstrate that IL - 27 has a unique role in controlling immunopathology without impacting on host defense, and might therefore represent a promising candidate for immunomodulatory therapy of viral pneumonia.»

It was a rich and rewarding workplace for a novice, surrounded by people who were experts in disparate aspects of tuberculosis research including clinical trials, epidemiology, and immunopathology.

Immunopathology is a branch of medicine that deals with immune responses associated with disease.

Taking advantage of infected patients, proprietary animal models of infection and new technological advances in the field of static and dynamic imaging, Immunopathology Unit tackles unresolved issues that include the means by which innate and adaptive immune cells traffic and function within the normal, cirrhotic or cancerous livers.

Dr. Lohman - Payne's area of research is viral immunopathology, with special interest in the impact of HIV exposure in...

The Department of Medical Biotechnology consists of many research groups covering biotechnology, vaccine development, infectious disease, immunopathology, microbiology, genetics and microbial immunity.

Systemic perspectives on the organism and organ level address fundamental questions of infection biology and shall contribute to reveal the molecular underpinnings of virus - induced immunopathologies and other inflammatory diseases.

However, challenge of mice given any of the vaccines led to occurrence of Th2 - type immunopathology suggesting hypersensitivity to SARS - CoV components was induced.

A summary of the SARS - CoV vaccine evaluations in animal models (including the current report) that indicated an evaluation for immunopathology after challenge is presented in Table 2.

The concern for an occurrence of lung immunopathology on challenge of mice vaccinated with an inactivated virus vaccine, as reported by Haagmans, et al. for ferrets and nonhuman primates, was seen by us after challenge of mice vaccinated with a SARS VLP vaccine [20].

That lung disease exhibited the characteristics of a Th2 - type immunopathology with eosinophils in the lung sections suggesting hypersensitivity that was reminiscent of the descriptions of the Th2 - type immunopathologic reaction in young children given an inactivated RSV vaccine and subsequently infected with naturally - occurring RSV [32]--[33].

Professor Emeritus Curtis Wilson, Jr., a world authority on the immunopathology of kidney diseases, joined Scripps in 1968.

As indicated, two reports attributed the immunopathology to presence of the N protein in the vaccine; however, we found the same immunopathologic reaction in animals given S protein vaccine only, although it appeared to be of lesser intensity.

The immunopathology in all experiments in the present study occurred in the absence of detectable virus in lungs of mice two days after challenge with infectious virus.

In this regard, animal model studies with FIPV in cats and RSV in mice have indicated that viral surface proteins may be the sensitizing protein of inactivated vaccines for immunopathology with infection [32], [45].

As indicated, strong animal model evidence indicates expression of the N protein by SARS - CoV vector vaccines can induce sensitization leading to a Th2 — type immunopathology with infection.

In contrast to our results, those studies did not find clear evidence of the Th2 type immunopathology on challenge of mice given a vector vaccine for the S protein.

To be certain the Th2 type immunopathology was elicited by the S protein vaccine in our studies and in hopes a greater immune response would result from higher dosages of the vaccine and induce greater protection against infection as well as reduce or prevent the immunopathology, our experiment 2 used up to 9 µg of the S protein for immunization.

Histopathology seen in animals given one of the SARS - CoV vaccines was uniformly a Th2 - type immunopathology with prominent eosinophil infiltration, confirmed with special eosinophil stains.

While increased titers of serum antibody were induced and no virus was detected day two after challenge in most animals, the Th2 - type immunopathology occurred after challenge, and the immunopathology seen earlier after vaccination with the DI whole virus vaccine was seen again.

Using clinical samples we would like to create an immunoprofile of activated B cells and memory B cells that may provide prognostic markers for dengue immunity and / or immunopathology.

At Duke he also served as Director of the Duke - VAMC Immunogenetics - Transplantation Laboratory, Director of the Duke Immunopathology Lab, and chief of the Renal and Transplant Pathology services.

The Department of Medical Biotechnologies consists of many research groups covering biotechnology, vaccine development, infectious disease, immunopathology, microbiology, genetics and microbial immunity.

Gastrointestinal inflammation is evident in the dogs with non-specific dietary sensitivity In collaboration with researchers at the School of Veterinary Medicine in Hannover, Germany, and the University of Bristol, UK, WALTHAM investigated the morphology and immunopathology of the small and large intestine in dogs with non-specific dietary sensitivity (Zentek et al. 2002).