Sentences with phrase «of immunotherapy strategies»
Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.
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In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.
«Our research sheds light on the mechanism of this impairment, pointing us in the direction of new strategies for improving the response to immunotherapy.»
Using an approach developed at Maisonneuve - Rosemont, consisting of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41 %, a record level using this strategy.
Identifying those two molecular targets could help in the design of better vaccine strategies and tumor immunotherapies.»
Therefore, «this finding may represent a future therapeutic strategic to combine with other strategies, such as immunotherapy, chemotherapy or inhibitors against specific signalling routes of the tumour cells.»
Traditional treatments are invasive and can impair the quality of life of patients, underscoring the need for alternative therapeutic strategies, including immunotherapy.
These results, published in Nature Communications, have the potential to improve current cancer immunotherapy strategies, especially in relation to the prevention of metastasis (dissemination of the tumor to organs distant from the site of origin).
Moreover, the efficiency of immunotherapy was further increased by combining this adoptive transfer with the current clinical strategy of reactivating the T cell antitumor response with antibodies to the receptor PD - 1.
The results show that generation of an optimal immune response to cancer requires cooperation between two types of memory T cell — one circulating in the blood and the other resident in tissues — that can be reactivated with current immunotherapy strategies.
«Our results in experimental models of cancer suggest a new therapeutic strategy based on inhibiting the microRNA machinery — or the Let - 7 microRNAs — specifically in the TAMs, which may unleash the power of mainstream immunotherapies, such as immune checkpoint inhibitors.»
Immunotherapy is a promising strategy for the treatment of Alzheimer's that uses antibodies to stimulate the immune system to remove pieces of a protein called amyloid beta which accumulates in the brain (in deposits known as plaques) and is thought to be a major factor driving Alzheimer's neurodegenerative effects.
Targeting negative regulators downstream of the TCR represents a novel strategy to improve cancer immunotherapy.
We have identified a major pathway by which these kinds of cells try to disable immune cells, and formulated a strategy for exploiting that weakness,» says the study's principal investigator, Kunle Odunsi, MD, PhD, FRCOG, FACOG, Deputy Director and Chair of Gynecology at Roswell Park, and Executive Director of its Center for Immunotherapy.
Immunotherapeutic strategies are rapidly evolving, and recent advancements in cell selection and gene editing have reshaped the reality of immunotherapy.
Building on clinical data from several single - agent immunotherapy clinical trials, and by engaging scientists with unique and complementary expertise from eight institutions and three industry partners, the BEAT - HIV Collaboratory's central mission will be to develop and test innovative combined immunotherapy strategies to eradicate and / or permanently suppress HIV replication in the absence of ART.
«The IASLC, being a global, multidisciplinary organization, is uniquely positioned to coordinate a harmonized strategy that can bring people together to show how the culture of lung cancer should reflect hope, as advances in lung cancer screening and early detection, personalized therapies, and immunotherapies are making a real impact in patients» lives.»
This treatment represents a second generation approach to the same telomerase loaded, dendritic cell vaccination immunotherapy strategy that has been tested in two previous clinical trials of our AST - VAC1 product.
We are developing cutting - edge discovery platforms and product strategies for effective cancer immunotherapies that we believe take into consideration the limitations of other approaches, as well as leveraging different mechanisms of action to address the risk of reliance on a single approach.
The intent of the effort is to build off the identified immunologic factors that may be modulated to improve immunotherapy for CRC patients, with the goal that the biomarkers and treatment strategies identified in the manuscript will become part of the routine management of colorectal cancer (CRC).
The success of immunotherapy has unleashed the energies of a multitude of scientists to further advance this novel strategy.»
«Insights derived from these data will be critical to improving the effectiveness of current cancer immunotherapy treatments and developing new immune - based treatment strategies,» said Justin Guinney, Ph.D., principal investigator, director of computational oncology and bioinformatics at Sage Bionetworks.
In this eBook, we examine the complexity of the tumor microenvironment, explore technologies that are innovating basic and translational research, and strategies that are advancing immunotherapy into the clinic.
One strategy is the use of anti-PD1 / PDL1 immunotherapies.
A novel approach to cancer immunotherapy — strategies designed to induce the immune system to attack cancer cells — may provide a new and cost - effective weapon against some of the most deadly tumors, including ovarian cancer and mesothelioma.
In an effort to accelerate the development, refinement, and approval of more cancer immunotherapies, the Cancer Research Institute has a developed a comprehensive strategy that draws upon several complementary resources and programs.
Immunotherapy's time is now, and he is excited to be working at the forefront of strategies that could make the approach a treatment option for any patient in need.
In doing so, he is devising inventive strategies to circumvent the hurdles that prevent immunotherapy from being cost - effective, widely available and effective against many types of cancer.
Although cancer immunotherapy is changing the paradigm of how cancer is treated, there is an urgent need to develop predictive biomarkers to identify patients who are most likely to benefit from various immunotherapeutic strategies.