The exocrine pancreas also produces bacteriostatic peptides and defensins that regulate the upper GI flora, and has a role in maintenance
of the intestinal mucosa and glucose homeostasis.
Cario, E., Bacterial interactions with cells
of the intestinal mucosa: Toll - like receptors and NOD2.
Lactobacillus spp. could be considered a potential opportunistic pathogen whenever there is disruption of the physiologic architecture
of the intestinal mucosa, such as in abdominal surgery, endoscopic procedures, or enteric pathologies.
Derangement of the homeostasis between bacteria and host - derived signals provokes intestinal barrier malfunction leading to bacterial translocation, i.e. the bacteria (or bacterial products) transport from the intestinal lumen into the lamina propria [part
of the intestinal mucosa] and, eventually, to extra-intestinal sites.
Irritation and inflammation
of the intestinal mucosa may occur, leading to an abnormal increase in intestinal permeability or «leaky gut.»
Lactobacillus accelerates ISCs regeneration to protect the integrity
of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL - 22 — Qihang Hou — Cell Death and Differentiation
The current study differs from previous reports in that intestinal swabs, which provided a direct method of looking at specific areas
of the intestinal mucosa, were studied instead of only relying on stool samples.
Further investigations showed that the mutation causes reduced CTLA - 4 function, which led to increased infiltration
of the intestinal mucosa by T - cells and therefore to chronic diarrhea.
Not exact matches
«It has been shown in mice that live immune cells in breast milk pass through the
intestinal mucosa into the blood circulation
of the pups and engraft in various tissues,» says Hassiotou.
Be it through
mucosa or the
intestinal lining, different tissues and surfaces
of our body are entry gates for bacterial pathogens.
Abstract: Gastric
intestinal metaplasia is a precancerous change
of the
mucosa of the stomach with
intestinal epithelium, and is associated with an increased risk
of dysplasia and cancer.
Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration
of HIV through the
intestinal epithelial barrier; ii) the cellular targets in the
mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement
of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role
of antibodies with different effector functions in changing the pathways
of the virus.
In specific Viral evolution and transmission Unit determines the pathways
of HIV within the
intestinal mucosa, which is the site
of viral entry, replication and persistence.
Both in vitro and in vivo, dex significantly increases vitamin D receptor (VDR) ligand binding in the tumor while decreasing binding in
intestinal mucosa, the site
of calcium absorption.
Furthermore, glutamine stimulates growth
of the small
intestinal mucosa in young animals and also enhances ion transport by the gut in neonates and adults.
GALT interacts strictly with gastrointestinal functions in a dynamic manner; for instance, by increasing
intestinal permeability in replay to particular stimulations, or orientating the immune response towards luminal content, allowing either tolerance or elimination / degradation
of luminal antigens, or sometimes provoking damage to the
intestinal mucosa, such as in coeliac disease or food allergy.
In 2011, researchers in Germany found that exposure to stress was responsible for alterations in gut motility, an increase in
intestinal permeability, and negative effects on the
intestinal microbiota, as well as the regenerative capacity
of the gut
mucosa.
Celiac disease is characterized by diffuse damage to the proximal small
intestinal mucosa that results in malabsorption
of most nutrients.
Bifidobacterium, friendly or probiotic bacteria, also grew in numbers and kept increasing, as well as Revotella, a producer
of short chain fatty acids, which protects the
intestinal mucosa and function as neurotransmitters.
By assessing the permeation
of water - soluble molecules lactulose and mannitol through the
intestinal mucosa after testing a urine sample collected after the drink, accurate information is obtained regarding the integrity and function
of the lining
of the small intestine.
Thanks to its high fiber content (about 33 % for not pealed cadaobeans) cocoa can limit constipation by stimulating
intestinal transit and its polyphenols help fortify the
intestinal mucosa, where the most important part (80 percent)
of our immune system is located.
They fed 100 mg
of berberine or a placebo to rats for several weeks and noted that «berberine treatment not only augments GLP2 secretion and improves diabetes, but is also effective in repairing the damaged
intestinal mucosa, restoring
intestinal permeability and improving endotoxemia».
Orally ingested plant lectins remaining at least partially undigested in the gut may bind to a wide variety
of cell mem - branes and glycoconjugates
of the
intestinal and colonic
mucosa, leading to various deleterious effects on the
mucosa itself as well as on the
intestinal bacterial flora and other inner organs (26, 27).
The altered
intestinal permeability allows the
mucosa to be exposed to bacterial toxins with bacterial invasion
of the
mucosa.
It is proposed that altered
intestinal permeability allows the
mucosa to be exposed to bacterial degradation products or other toxins and together with reduced chemotaxic response and altered neutrophil function due to NSAID's, this series
of events leads to bacterial invasion
of the
mucosa which is evident by the techniques
of 111Indium leucocyte scans and faecal collections.
In the present study, we investigated the effect
of glutamine on indomethacin - induced changes in the small
intestinal mucosa.
Candida is a type
of fungus (a yeast to be exact) that resides in your body's microbiome — which includes the
intestinal tract, skin,
mucosa, and genitals.
glutamine stimulates growth
of the small
intestinal mucosa in young animals and also enhances ion transport by the gut in neonates and adults
By adhering to a gluten - free diet, people are able to recover
intestinal mucosa, improve their
intestinal symptoms, and drastically lower the risk
of complications that can develop as a result
of the condition.
«L - Glutamate supplementation improves small
intestinal architecture and enhances the expressions
of jejunal
mucosa amino acid receptors and transporters in weaning piglets.»
Also, the bacterial species
of the probiotic preparation should adhere to the
intestinal mucosa to prolong the time
of interaction.
These formulas are high in energy, and contain ingredients to help maintain the balance
of GI microflora and
intestinal mucosa integrity.
Since the biopsy procedure only samples the
mucosa it is possible to miss detecting a tumor that involves only the deeper layers
of the
intestinal tract.
Pathogenesis
of canine IBD - What innate immunity can teach us Karin Allenspach Dr Med Vet, FVH, Dipl ECVIM - CA, PhD, FHEA, Hatfield, UK Each day the
intestinal mucosa is challenged with a huge array
of antigens, either from food or the microbial flora in the
intestinal lumen.
Hookworms can cause a number
of difficulties for the infected animal including anemia since these worms feed off the animal's blood by damaging the
intestinal mucosa.
Intestinal lymphangiectasia has been identified as a cause of PLE in Yorkies in addition to abnormal structures in the intestinal mucosa referred to as cr
Intestinal lymphangiectasia has been identified as a cause
of PLE in Yorkies in addition to abnormal structures in the
intestinal mucosa referred to as cr
intestinal mucosa referred to as crypt cysts.
ROGERS Q.R.; PHANG, J.M. Deficiency
of pyrroline -5-carboxylate synthase in the
intestinal mucosa of the cat.