Sentences with phrase «of irinotecan»

A new animal model of intestinal mucositis induced by the combination of irinotecan and 5 - fluorouracil in mice.

Choy, H, Chakravarthy, A. Phase I trial of Irinotecan and concurrent radiation therapy for stage III non-small cell lung cancer.

The researchers proposed that the therapeutic benefit of the irinotecan containing nanoparticles may be enhanced when combined with the injection of iRGD.

Not exact matches

The NAPOLI - 1 (NAnoliPOsomaL Irinotecan) Phase 3 study — a final confirmation of a drug's safety and effectiveness — was conducted among patients with metastatic pancreatic cancer who previously received gemcitibine, which has been the standard - of - care therapy for such patients.

The abstract title was: CTC 11 - 001: Phase I study of Carfilzomib (C) + Irinotecan (I) in relapsed solid tumors.

Findings were presented at the WCLC are based on the updated results of 12 lung cancer patients enrolled in the clinical trial with pembro and irinotecan or gemcitabine with or without vinorelbine or docetaxel.

This causes diarrhea in up to 90 % of patients who take irinotecan.

Redinbo and his team now characterize various forms of Beta - glucuronidase produced by different strains of bacteria residing in the gut, and they show that inhibiting GI bacterial Beta - glucuronidases in mice does not affect irinotecan that is circulating in the blood and is needed to combat cancer.

Here's one example of how this information might be useful for doctors and patients: Irinotecan is a drug only indicated by the FDA for use in colon cancer.

Drugs like fluorouracil, oxaliplatin and irinotecan work by mimicking and damaging DNA molecules, or inhibiting enzymes involved in cell and DNA replication, slowing the uncontrolled growth of tumor cells.

The introduction of nanocarriers as delivery vehicles for common chemotherapy agents such as the drug irinotecan, has led to improved survival of patients with this disease.

Patients responded to irinotecan at the same rate whether they had low or high levels of these genes.

Lee says the research team will measure the amount of methylation in patients» cells when they begin their treatment and the presence of genes associated with irinotecan resistance, among other possible biomarkers.

The current study was based on previous studies in the laboratory of Nita Ahuja, M.D., director of the Sarcoma and Peritoneal Surface Malignancy Program and professor of surgery at the Johns Hopkins University School of Medicine, which showed that guadecitabine limited the growth of colorectal cancer cell lines when combined with irinotecan, says Azad.

Scientists leading the new study will also look for biomarkers in patients that could help determine which of them are most likely to benefit from guadecitabine and irinotecan.

While thousands of agents based on camptothecin have been synthesized, and two of these analogs — irinotecan and topotecan — have been approved for treatment of many solid - tumor cancers, these compounds typically are highly toxic to healthy cells, and not all of them have proven effective as anticancer agents.

Phase I Clinical Trial of VX - 970 in Combination with the Topoisomerase I Inhibitor Irinotecan in Patients with Advanced Solid Tumors

A Multicenter, Randomized, Open - label, 3 - Arm Phase 3 Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan / Cetuximab or Infusional 5 - Fluorouracil (5 - FU) / Folinic Acid (FA) / Irinotecan (FOLFIRI) / Cetuximab with a Safety Lead - in of Encorafenib + Binimetinib + Cetuximab in Patients with BRAF V600E - mutant Metastatic Colorectal Cancer

Phase I / II Study to Evaluate the Safety, Efficacy, and Novel PET / CT Imaging Biomarkers of CB - 839 in Combination with Panitumumab and Irinotecan in Patients with Metastatic and Refractory RAS Wildtype Colorectal Cancer

He is the Principal Investigator of international Phase - II, randomized trial of Chimeric 14.18 or Temsirolimus in combination with Irinotecan / Temozolomide through Children's Oncology Group (COG).

This is the first study to evaluate the safety and clinical activity of the combination of oral pazopanib, intravenous or oral irinotecan, and oral temozolomide in pediatric and young adult patients with relapsed or refractory sarcomas.

Dr. Innocenti is a co-inventor of the FDA - approved UGT1A1 genetic test for patients treated with irinotecan.

One of Dr. Innocentis exemplary achievements is the elucidation of the genetic basis of severe neutropenia in cancer patients treated with irinotecan, a poster child for pharmacogenetic.

Irinotecan causes severe diarrhea and neutropenia, a decrease of white blood cells, in 20 percent to 35 percent of patients.

Treatment of the Gb3 - expressing gastric carcinoma cell line St3051 with STxB coupled to SN38, the active metabolite of the topoisomerase type I inhibitor irinotecan, resulted in > 100-fold increased cytotoxicity, as compared with irinotecan alone.

Curcumin might also interfere with the absorption and efficacy of the chemotherapy drug irinotecan, used to treat colon cancer.