A comprehensive analysis of transfection - assisted delivery
of iron oxide nanoparticles to dendritic cells.
Nickels M, Xie JP, Cobb J, Gore JC and Pham W. Functionalization
of Iron Oxide Nanoparticles With a Versatile Epoxy Amine Linker.
Yet, to be effective, the size
of the iron oxide nanoparticles had to be just right — and had to be maintained in a strong matrix that was both flexible and resilient to deal with large volume changes while optimally conducting electricity.
Not exact matches
The researchers engineered
nanoparticle complexes containing small amounts
of ropivacaine and the
iron oxide mineral magnetite.
One promising idea, known as magnetic hyperthermia, involves injecting minuscule «
nanoparticles,» basically microscopic lumps
of iron oxide or other compounds, into tumors to make them magnetic.
Heat treatment after an injection
of traditional
iron oxide nanoparticles had no significant effect on the tumors.
An
iron oxide nanoparticle applied to teeth prior to treatment with hydrogen peroxide effectively reduced the onset and severity
of cavities (indicated with red arrows) in rats.
HST researchers have experimented with polymer - coated
iron oxide nanoparticles held together by DNA tethers to help them create a visual image
of a tumor through magnetic resonance imaging.
To create a diabetes vaccine, Santamaria has attached a cocktail
of antigens from pancreatic beta cells to synthetic
iron oxide nanoparticles.
Gao and Koo reached out to Cormode, who had experience working with
iron oxide nanoparticles in a radiological imaging context, to help them synthesize, characterize and test the effectiveness
of the
nanoparticles, several forms
of which are already FDA - approved for imaging in humans.
A combination
of iron -
oxide nanoparticles and an alternating magnetic field, which together generate heat, have activated an immune system response to tumors in mice according to an accepted manuscript by Dartmouth - Hitchcock Norris Cotton Center researchers in the journal Nanomedicine: Nanotechnology, Biology and Medicine released online on February 24, 2014.
Previous cancer studies had shown that by injecting tumors with magnetic
nanoparticles made
of iron oxide — «essentially rust, with well - tuned magnetic properties,» Anikeeva says — then exposing them to rapidly alternating magnetic fields, excited
nanoparticles can be used to heat and destroy cancer tumors while leaving surrounding, healthy tissue intact.
An endowed professor
of pediatric cardiology at Children's Hospital
of Philadelphia in Pennsylvania, Levy had been working with his team on biodegradable polymer
nanoparticles infused with
iron oxide.
As an alternative, contrast agents based on
iron oxide nanoparticles are practically unused because
of the difficult readability
of the results.
Researchers at Umeå University, together with researchers at Uppsala University and Stockholm University, show in a new study how nitrogen doped graphene can be rolled into perfect Archimedean nano scrolls by adhering magnetic
iron oxide nanoparticles on the surface
of the graphene sheets.
HYEON Taeghwan, director
of the Center for
Nanoparticle Research explains: «Let's take the example
of a MRI analysis
of a brain with Alzheimer's:
iron oxide in the blood vessels would appear as black and the amyloid plaques as gray.
In place
of gadolinium - based contrast agents, the researchers have found that they can produce similar MRI contrast with tiny
nanoparticles of iron oxide that have been treated with a zwitterion coating.
It shows that the magnetic interaction between the
iron oxide nanoparticles is one
of the main effects behind the scroll formation.
To get round this, Wilhelm Roell at the University
of Bonn in Germany and his colleagues loaded muscle stem cells with
iron oxide nanoparticles to make them magnetic.
The team used
iron oxide for the core
of the
nanoparticles, which not only enables the team to use them for magnetic resonance imaging, but opens up possibilities in remote guidance and localized magnetic heating to hasten the breaking up
of the clots.
I've been experimenting with T10 dextran coated
iron oxide nanoparticles, obviously not the same as fullerenes, but still a very interesting tool, I've been testing if the coating is giving the particle antioxidant abilities because
of it's the (basically) indigestable sugar chains (glucose) creating a high surface area which are largely made from hydroxyl groups, I hypothesised this act's as a «sink» for reactive oxygen species converting them to water.
«Deficient neuron - microglia signaling results in impaired functional brain connectivity and social behavior» Y. Zhan, R.C. Paolicelli, F. Sforazzini, L. Weinhard, G. Bolasco, F. Pagani, A. L. Vyssotski, A. Bifone, A. Gozzi, D. Ragozzino, C.T. Gross Nature Neuroscience 17 (3), 400-4006 (2014) «USPIO - loaded Red Blood Cells as a biomimetic MR contrast agent: a relaxometric study» A. Boni, D. Ceratti, A. Antonelli, C. Sfara, M. Magnani, E. Manuali, S. Salamida, A. Gozzi, and A. Bifone Contrast Media and Molecular Imaging 9, 229 - 236 (2014) «Distributed BOLD and CBV - weighted resting - state networks in the mouse brain» F. Sforazzini, A.J. Schwarz, A. Galbusera, A. Bifone, and A. Gozzi NeuroImage 87, 403 - 415 (2014) «Antimicrobial peptides design by evolutionary multiobject optimization» G. Maccari, M. Di Luca, R. Nifosì, F. Caldarelli, G. Signore, C. Boccardi, and A. Bifone PloS Computational Biology 9 (9): e1003212 (2013) «Differential effect
of orexin - 1 and crf - 1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor yohimbine» A. Gozzi, S: Lepore, E: Merlo Pich, and A. Bifone Neuropsychopharmacology 38 (11): 2120 - 2130 (2013) «Water dispersal and functionalization
of hydrophobic
iron oxide nanoparticles with lipid - modified poly (amidoamine) dendrimers» A. Boni, L. Albertazzi, C. Innocenti, M. Gemmi, and A. Bifone.
A 2017 study co-authored by John Bischof, professor
of mechanical engineering at the University
of Minnesota, and published in Science Translational Medicine, used specially coated
iron oxide nanoparticles.
Napier's presentation, titled «Superparamagnetic
Iron Oxide Nanoparticles for Delivery
of DNA - based Contraceptive Vaccines for Feral Cats,» dealt with a portion
of Napier's research in developing and delivering contraceptives to feral cats.