Sentences with phrase «of islet amyloid polypeptide»

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate - sized toxic amyloid particles

Islet amyloid deposits, composed predominantly of a misfolded and aggregated form of the islet amyloid polypeptide (IAPP), are observed in > 90 % of patients with T2D (Westermark, 1972; Clark et al., 1988; Betsholtz et al., 1989; Johnson et al., 1989).

To corroborate the findings, the researchers also developed a novel mouse model that was deficient for autophagy specifically in beta cells with expression of the human form of islet amyloid polypeptide.

Not exact matches

People with Type 2 diabetes have an excess of a protein called islet amyloid polypeptide, or IAPP, and the accumulation of this protein is linked to the loss of insulin - producing pancreatic beta cells.

Islet amyloid polypeptide (IAPP): cDNA cloning and identification of an amyloidogenic region associated with the species - specific occurrence of age - related diabetes mellitus

The 37 - amino - acid polypeptide amylin is the principal constituent of the amyloid deposits that form in the islets of Langerhans in patients with type - 2 diabetes mellitus, but its role in the pathogenesis of this disease is unresolved.

Pancreatic islet amyloid, formed from islet amyloid polypeptide, is found in 96 % of Type II (non-insulin-dependent) diabetic patients.