Chs3 recruits Chs4 to Ste24, which cleaves off the aaX peptide allowing carboxy - methylation
of the isoprenoid cysteine by Ste14.
Previous work also suggested synergistic impact
of isoprenoids on tumor growth, a finding remaining to be confirmed in prostate cancer.
This tumor - targeted action
of isoprenoids was manifested in animal studies showing no toxicity
of isoprenoids at tumor - suppressive doses (reviewed by Mo & Elson, Exp Biol Med, 2004, 229:567 - 85).
So far, our structures span protein families such as cyclophilins, kinases and proteases as well as pathways for biosynthesis, salvage and metabolism
of isoprenoids, fatty acids, phospholipids, pyrimidines, purines and polyamines.
«We think that understanding the role
of isoprenoids during gametocytogenesis and identifying metabolic steps absent or sufficiently different from its human host will allow us to design more efficient drugs to block malaria transmission, which is one of the key components for malaria elimination and eradication,» Cassera said.
Not exact matches
Isoprenoid - mediated suppression
of HMG CoA reductase in tumors was previously correlated to growth arrest; the latter was attenuated by supplemental mevalonate.
Considering the medical and cosmetic sector, a great number
of researches focused on the isolation
of tyrosinase inhibitors from both terrestrial and marine environment belonging to diverse chemical classes such as phenolics (flavonoids, lignans, stilbenes, coumarins, arylbenzofurans, tannins), megastigmane - type (nor -
isoprenoid), terpenes, cyclic peptides, alkaloids and steroids.
What's more, by swapping a couple genes, these bacteria can potentially produce any
of the so - called
isoprenoids, a large and diverse class
of natural compounds.
I became acquainted with a group
of natural products called
isoprenoids.
Specifically, she wants to understand the role that specific metabolites called
isoprenoids play in the early stages
of development.
Integrated analysis
of isopentenyl pyrophosphate (IPP) toxicity in
isoprenoid - producing Escherichia coli.
Such records may be obtained using a quite recently developed biomarker approach that is based on the determination
of a highly branched
isoprenoid (HBI) with 25 carbons (C25 HBI monoene) 29.
Smik, L., Cabedo - Sanz & Belt, S. T. Semi-quantitative estimates
of paleo Arctic sea ice concentration based on source - specific highly branched
isoprenoid alkenes: a further development
of the PIP25 index.