The term, «canine familial dermatomyositis» currently should be reserved for dogs with clinical and histopathologic evidence
of a juvenile onset heritable inflammatory disease affecting skin and muscle in a breed known to be at increased risk.
In most cases
of juvenile onset diabetes, insulin injections are necessary to maintain level glucose levels.
Research has shown that babies who do not receive breast milk are more likely to be admitted to hospital for diarrhoea and respiratory illness and to develop eczema, wheeze and have an increased incidence
of juvenile onset diabetes.
Nursing, combined with delaying the introduction of cow's milk reduces the risk
of juvenile onset diabetes and lowers the amount of insulin release in infants.
Not exact matches
«My father has Type 2 adult
onset diabetes, and my uncle died in his 30s
of Type 1
juvenile diabetes.»
Insulin - Dependent Diabetes Mellitus (IDDM, Type I, or
Juvenile Onset Diabetes): IDDM is usually seen in people under the age
of 25 and results in absolute insulin deficiency.Type 1 diabetics have to take insulin every day.
The fish oil study examined a different question: In children at risk for type 1 (
juvenile onset) diabetes, does the consumption
of fish oil reduce their risk
of developing early signs
of the disease?
Although
juvenile glaucoma accounts for fewer than 1 %
of all cases, early indications are that mutations in the TIGR gene are behind at least 3 %
of adult -
onset cases as well.
Among health issues that some advocates have linked to chemical exposures: early pubescence in girls (BPA hastens the
onset of pubescence in
juvenile rats); asthma (car and truck exhaust can induce or worsen lung inflammation), and genital malformation (phthalates have been linked to lower sperm count and deformed penises in rats).
Mutations
of the huntingtin protein (HTT) gene underlie both adult -
onset and
juvenile forms
of Huntington's disease (HD).
Geneticist Xiao - Jiang Li and colleagues recently published a paper in Cell Reports that may explain why more aggressive
juvenile -
onset forms
of polyglutamine diseases have different symptoms and pathology.
GM1 gangliosidosis can be classified into three major clinical phenotypes according to the age
of onset and severity
of symptoms: Type I (infantile), Type II (late infantile /
juvenile) and Type III (adult).
Though the plot will
of course clear up as players progress, the
onset leaves one feeling as if they're reading a library book from which the first chapter has been ripped out by some
juvenile miscreant.
Juvenile -
onset demodicosis is further categorized as localized or generalized according to the extent
of the disease.
Ultimately, any breed
of dog can develop
juvenile -
onset demodicosis.
Juvenile -
onset demodicosis typically occurs in dogs less than 18 months
of age.
Hyperglycemia is more common in older female dogs;
juvenile onset hypoglycemia, which manifests during the first year
of a puppy's life, is rare but does occur.
In puppies with hyperglycemia and
juvenile onset diabetes, you may notice a loss
of weight despite your puppy eating just about everything you feed her.
We are currently in the process
of DNA testing our dogs for the gene that carries the early
onset Juvenile Cataract (DNA for JC) and a Few more tests for the frenchies.
In dogs under 1 year
of age, demodex is referred to as
Juvenile -
onset demodicosis, where in adults it is called generalized adult -
onset demodicosis.
Differential diagnoses for this presentation include
juvenile onset demodicosis with a secondary bacterial infection, dermatophytosis, contact dermatitis, and early stages
of mild
juvenile sterile granulomatous dermatitis and lymphadenitis (puppy strangles).
The
juvenile puppy period generally begins at age 10 weeks and lasts until puberty and the
onset of sexual maturity.
Canine familial dermatomyositis (DM): A
juvenile onset heritable inflammatory disease
of uncertain etiology affecting skin and muscle, seen predominantly in the Collie, Shetland Sheepdog, and their related cross-breeds.
The reason for this is not fully understood, but abnormalities in cell - mediated immunity are postulated.1 Gathering a detailed history is also important for categorizing the type
of demodicosis (i.e.,
juvenile versus adult
onset).
Cataracts may be classified by cause (i.e. primary, secondary); age
of onset (e.g. congenital,
juvenile, senile); location within the lens (e.g. capsular, anterior cortical, posterior cortical, Y - sutural, nuclear, axial, paraxial, equatorial); and degree
of completeness (i.e. incipient, immature, mature, hypermature).
This is called a «
juvenile onset» form
of disease.
Finally, a severe form
of autoimmune arthritis called
juvenile onset polyarthritis can strike Akitas under a year old.
For example, Boston Terriers suffer from both
juvenile and late -
onset forms
of HC, and it has been shown that the HSF4 mutation is responsible for the early -
onset cataract only (3).
The disease can also be classified based on the age
of onset —
juvenile onset demodicosis occurs in dogs around a year
of age or less.
Other rare forms
of hypothyroidism in dogs include neoplastic destruction
of thyroid tissue and congenital (or
juvenile -
onset) hypothyroidism.
In dogs with congenital hypopituitarism (pituitary dwarfism, see
Juvenile -
onset Panhypopituitarism), there may be variable degrees
of thyroidal, adrenocortical, and gonadal deficiency, but clinical signs are primarily related to growth hormone deficiency.
The age at the
onset of symptoms determines the diagnosis, with mange beginning before about 15 months
of age considered
juvenile.
Generalized red mange is classified as either
juvenile - or adult -
onset, depending on the breed and age
of your dog when he develops the condition.
For about three years now we have seen significant strides in a lot
of areas and one
of the most progressive has been in the area
of adults, with both adult and
juvenile onset type -LSB-...]
Soluble MICB in Plasma and Urine Explains Population Expansions
of NKG2D + CD4 T Cells Inpatients with
Juvenile -
Onset Systemic Lupus Erythematosus
The second contrast tested the prediction that the adult - depressed and never - depressed groups would not differ significantly on the early childhood risk factors because the effects
of childhood adversity on depression
onset decline with age.14 The third contrast compared the
juvenile - depressed and
juvenile / adult — depressed groups on the early childhood risk factors.
Third, the identification
of risk factors for
juvenile -
onset MDD in no way ensures their causal status.47 Although the early childhood risk factors (except childhood sexual abuse) covered the period prior to the first diagnosis
of MDD (and could thus be ruled out as consequences
of depression), future research is needed to determine whether changes in any
of the childhood risk factors would decrease the likelihood
of MDD, thus implying their causal status.
Jaffee SR, Moffitt TE, Caspi A, et al.Differences in early childhood risk factors for
juvenile -
onset and adult -
onset depression.Arch Gen Psychiatry2002 Mar; 59:215 — 22OpenUrlCrossRefPubMedWeb
of Science QUESTION: Are childhood biopsychosocial risk factors associated with
juvenile onset different from those associated with adult
onset major depressive disorder (MDD)?
Distinctions based on age
of onset have proven important for understanding heterogeneity within attention - deficit / hyperactivity disorder51 and antisocial disorder, 52,53 in which childhood
onset has worse implications for course, recurrence, familial transmission, and treatment resistance.54 Research on schizophrenia is also benefiting from a focus on childhood neurodevelopmental processes55 and
juvenile -
onset symptoms.56 The present study and others1 illustrate that the distinction between
juvenile vs adult -
onset MDD is important for understanding heterogeneity within depression as well.
SEVERAL FINDINGS suggest that
juvenile - and adult -
onset major depressive disorder (MDD) have distinct origins.1 First, although a significant proportion
of depressed children become depressed adults, 2,3 most individuals who experience depression in adulthood were not depressed as children.4 Second,
juvenile -
onset MDD is associated with increased risk for MDD among the first - degree relatives
of depressed probands in clinical and community samples.4 - 8 Third, the children
of depressed parents are at high risk for
juvenile -
onset MDD compared with the children
of nondepressed parents, and this association is explained by early parental age at
onset of MDD.9
Moreover, studies with larger samples
of juvenile -
onset cases are needed.
The
juvenile - depressed group had a significantly earlier age
of MDD
onset (mean [SD], 12 [1.84] years) compared with the
juvenile / adult — depressed group (13 [1.47] years; t366 = 2.93; P ≤.01).
Given the inconsistent findings in the literature regarding heterogeneity within
juvenile -
onset MDD, no predictions were made regarding the direction
of effects.
A range
of childhood psychosocial risk factors have been associated with depression, including characteristics
of the child (eg, behavioral and socioemotional problems, poor school performance), characteristics
of the parents (eg, parent psychopathology, rejecting or intrusive behavior), and family circumstances (eg, the loss
of a parent, physical or sexual violence, family discord).12 - 15 However, it has not been shown decisively whether these risks distinguish
juvenile from adult -
onset MDD.
χ2 Analyses were conducted to show associations between depression -
onset status and other
juvenile and adulthood diagnoses
of mental disorder.
This study is the first to distinguish prospectively between
juvenile - and adult -
onset cases
of MDD in a representative birth cohort followed up from childhood into adulthood.
The most important take home message for clinicians is that
juvenile onset depression that recurred in adulthood was characterised by a higher proportion
of women, internalising problems, temperamental inhibition, adult anxiety, and history
of parental loss in childhood than
juvenile onset depression that did not recur in adulthood.
That is, regardless
of whether MDD persisted beyond childhood, the early childhood risk factors distinguished the
juvenile -
onset groups from the adult -
onset group.
To test specific predictions about group differences, orthogonal - planned contrasts were conducted.43 The first contrast tested the prediction that the
juvenile - depressed and
juvenile / adult — depressed groups would differ from the adult - depressed group because a growing body
of research suggests that
juvenile -
onset MDD is distinct from adult -
onset MDD.
On this basis, a significant proportion
of the
juvenile - depressed group was prepubertal and the
juvenile / adult — depressed group was pubertal or postpubertal at MDD
onset.