In addition to clustering AMPA receptors, via a dimerisation domain, PICK1 has been shown to have multiple effects in neurons including roles in the insertion of AMPA receptors (Daw et al 2000), the internalisation
of kainate receptors (Hirbec et al 2003) and the regulation of AMPA receptor subunit composition (Terashima et al 2004).
It has been shown to interact with a number of glutamate receptors - GluA2 and GluA3 AMPA receptor subunits (Dev et al 1999, Xia et al 1999), the GluK1 and GluK2 subuits
of the kainate receptor (Hirbec et al 2003) and the mGlu7 receptor (Dev et al 2000) via their extreme C - terminal PDZ binding motifs.
All inhibitors of glutamate transporters, with the exception
of the kainate - derivatives, have been substrates which are themselves transported.
Not exact matches
Publication
of Proof that Cot Death Babies Show Physiological Effects
of Gaseous Poisoning: «Decreased
Kainate Receptor Binding in the Arcuate Nucleus
of the Sudden Infant Death Syndrome», Journal
of Neuropathology and Experimental Neurology 1997; 56:1253 - 61: proof that cot death babies have neurochemical deficits consistent with poisoning by nerve gases.
The video relies on a cascade
of chemical reactions: When a neurotransmitter called
kainate binds to the surface
of an astrocyte, a molecular floodgate opens and sodium ions rush in.
This study, by Professor Jeremy Henley and co-workers reports a new type
of LTP that is controlled by
kainate receptors.
The whole - cell current response to glutamate and
kainate [a non-NMDA (N - methyl - D - aspartate) receptor agonist] was enhanced by forskolin, an activator
of adenylate cyclase.
Functional expression
of the cDNAs in cultured mammalian cells generated receptors displaying alpha - amino -3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)- selective binding pharmacology (AMPA = quisqualate greater than glutamate greater than
kainate) as well as cation channels gated by glutamate, AMPA, and
kainate and blocked by 6,7 - dinitroquinoxaline -2,3-dione (CNQX).
Although the
kainate compounds do not have this problem, they have low affinity action only on one
of the transporter subtypes.