Sentences with phrase «of ketamine»

«One of the primary effects of ketamine in the brain is to block the NMDA [N - methyl - d - aspartate] glutamate receptor,» said James W. Murrough, MD, principal investigator of the study, and Assistant Professor of Psychiatry and Neuroscience, and Associate Director of the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai.

We anesthetized cats in traps with an intramuscular injection of ketamine HC1 (10 mg / kg) and acepromazine (0.1 mg / kg).

Clements, J. A., Nimmo, W. S. & Grant, I. S. Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans.

Respiratory depression may occur following administration of high doses of Ketamine Hydrochloride Injection, USP.

At day 20 of gestation, one set of dams (n = 10) from each group was anesthetised with isoflurane and then maintained by a mixture of ketamine (40 mg • kg − 1) and xylazine (5 mg • kg − 1) injected intraperitoneally.

He envisions patients receiving a series of ketamine injections that would keep them depression - free for a month or more.

This is the first study to show benefits with an intranasal formulation of ketamine.

Janssen has developed a specific form of ketamine, called esketamine, that it is testing in five large clinical trials.

The researchers evaluated three potential biomarkers for detecting the effects of ketamine on human brain function.

Mice were anesthetized systemically with an intraperitoneal (i.p.) injection of 80 mg / kg of ketamine HCl (Fort Dodge Laboratories, Fort Dodge, IA) and 8.0 mg / kg of xylazine (Bayer Corporation, Shawnee Mission, KS).

Title: Quantifying the attenuation of the ketamine pharmacological magnetic resonance imaging response in humans: a validation using antipsychotic and glutamatergic agents Author: O. M. Doyle et al..

The first placebo - controlled study of ketamine's effect on social anxiety disorder has provides more evidence...

«The possible utility of ketamine in treating this population is an important avenue of study.»

Ketamine - enhanced psycho - pharmacotherapy attempts transcend presumable underline psychological causes of food addiction and limits an administration of ketamine to only a single session.

FEEVA opposes any re-classification of Ketamine which would limits its availability.

According to a statement from the World Veterinary Association, «WVA strongly objects to reclassification of ketamine, as this could lead to ketamine no longer being available to veterinary and medical clinicians, especially in remote areas.»

The World Veterinary Association, of which CVMA is a member, has joined the World Medical Association among others in urging the United Nations Commission on Narcotic Drugs not to restrict the availability of ketamine.

It all starts with a tranquilizer pistol, a missing friend, and a military outpost filled with a bunch of dicks just waiting to have 500cc worth of Ketamine shot in to their stupid faces.

«I'm very excited... to see whether this [also] applies to the long - lasting antidepressant effects of ketamine,» he says.

For intratibial injections, mice were anesthetized using a mixture of ketamine (100 mg / kg) and xylazine (10 mg / kg).

And to Gould's surprise, the metabolite did not cause side effects in the mice even at doses nearly 40 times higher than the antidepressant dose of ketamine.

For tracer injections, birds were anaesthetized by intramuscular injection of ketamine (Pfitzer, Freiburg, Germany) / rompun (Bayer, Leverkusen, Germany), and their heads were fixed in a custom - built stereotactic apparatus.

This completely eliminated the effect of the ketamine, regardless of the experimenter's sex.

The different effects of ketamine and memantine alter signals emanating from NMDA receptors, in particular those that determine antidepressant efficacy.

Gould and his colleagues used a battery of behavioural tests in mice to show that one of ketamine's breakdown products — a compound called (2R, 6 R)- hydroxynorketamine — is responsible for much of the drug's antidepressant effects.

Title: A comparison of the effects of ketamine and phencyclidine with other antagonists of the NMDA receptor in rodent assays of attention and working memory Author: J. Smith et al..

This important conclusion, albeit from tightly logical experiments in mice, must remain tentative until HNK is shown to be effective in patients with depression without the dissociative effects of ketamine.