This Registered Report describes the proposed replication plan
of key experiments from «Melanoma genome sequencing reveals frequent PREX2 mutations» by Berger and colleagues, published in Nature in 2012 (Berger et al., 2012).
This Registered report describes the proposed replication plan
of key experiments from «Interactions between cancer stem cells and their niche govern metastatic colonization» by Malanchi and colleagues, published in Nature in 2012 (Malanchi et al., 2012).
«Part of our trick is, that we use the pancreatic hormone glucagon as a vehicle to deliver thyroid hormone only into cells carrying a glucagon receptor,» says Christoffer Clemmensen, who led several
of the key experiments.
Not exact matches
The
experiment had a surprising dividend: offering
key lessons for Whole Foods» new «365» chain — smaller, lower - priced versions
of the flagship brand that will begin rolling out next year.
During a
key experiment in the 1990s, for example, researchers damaged the neocortex
of female hamsters after birth but spared deeper brain structures.
For example, my
experiments show that character - driven stories with emotional content result in a better understanding
of the
key points a speaker wishes to make and enable better recall
of these points weeks later.
Then there was the «Americanist» crisis at the beginning
of the twentieth century when, in the view
of many, Rome's hostility to
key ideas and institutions
of the American
experiment forced Catholicism into a countercultural ghetto.
Melinda's growth is being propelled in large part by four
key factors: the increasing popularity
of spicy foods; America's rapidly expanding population
of Central, South American and Caribbean immigrants; the widely recognized health benefits
of chile peppers; and the growing purchasing power
of Millennials who are more apt to
experiment with new spices and flavor profiles.
Budweiser is upholding its commitment to be the first beer on Mars by confirming upcoming
experiments on the International Space Station with plans to send and study barley — one
of its
key ingredients — into space in early December.
Um pesonal
experiments sorry nobody gave him 150million pounds to sign eonaldo or messi or 100 million pounds to sign a player oh plus another 400million to fill out the other ten sorry he was given ants and has still won our record signing 55million i mean other teams are able to spend more on bench sore pine slivered second strings than hes been on starters over the years and hes still won only manager invincible oh and then when the other clubs new we were low on cash and winning started injuring our star players and do nt say it does nt happen cause it does um he still won whole given ants to spend hes done amazing extend please one or to bad seasons compared to twenty great seasons and had our strikers finished their chances this year in 5 or six
key matches we'd be sitting pretty reall only 3 or two and a draw or saw and we'd be sittingin the thick
of itextend now that the board an owner are willing to spend snails for him finally atleast a little more than ants cause
of inflation
i do nt think it was much
of an
experiment, giroud was awful in istanbul, this was as much to motivate as to see how sanchez fits, the
key to sanchez working was ox's speed and ozil, but the 3 did not click...
It's important to keep in mind that breast milk and / or formula still provides the majority
of baby's nutrition up until about nine months (solids only provide about one fifth
of baby's nutrition up until this point, and then just under half
of baby's nutrition from nine to eleven months), which means that although important to introduce a wide variety
of foods early on (and certain
key nutrients), these first few months are largely for
experimenting, playing with and learning about food!
There are many text books available for
key stage 3 science, but we have found most
of them to be full
of theory with little room for hands - on science or questions, although they are interesting and provide good background to science, although there are some which suggest
experiments, many
of which can be done at home.
As part
of this,
experimenting with different positions is
key.
It represents our most recent — and most enduring —
experiment in global governance, as a place for states to convene, as the setter
of international norms, and as a provider
of key services, from emergency relief to human rights monitors and peacekeepers.
The BUAV noted that according to the review, one in ten
experiments «did not have a medical benefit»; and that a number
of key concerns were expressed by the review regarding animal welfare costs, the application and relevance to humans and the overstating
of medical benefits by researchers.
The study is missing
key information on what type
of hair was tested, as well as how the researchers made sure the combing force was consistent across
experiments.
Together, these
experiments show that the PERIOD3 gene likely plays a
key role in regulating the sleep - wake cycle, influencing mood and regulating the relationship between depression and seasonal changes in light availability, the team reports today in the Proceedings
of the National Academy
of Sciences.
A
key element in a particle - accelerator - based neutrino
experiment is the power
of the beam that gives birth to neutrinos: The more particles you can pack into that beam, the better your chance to see neutrinos interact in your detector.
Miniaturization is the
key:
Experiments that once required a room full
of lasers, optical elements, and vacuum systems can now fit in a device the size
of an ice chest, with the atoms trapped on the surface
of a microchip.
A daring treetop
experiment is yielding
key insights into the fate
of sensitive rainforest plants as air pollution rises.
Biodiversity, they have said, is the
key to stability — a hypothesis bolstered by field
experiments showing that removal
of one or more species can make a community less resilient.
The
key is that the mixture
of bubbles and liquid becomes acutely compressible, says John Hegseth, a physicist at the University
of New Orleans in Louisiana who took part in the
experiment.
By combining laboratory
experiments, cross-cultural fieldwork, and analysis
of the historical record, an interdisciplinary team has proposed that belief in judgmental deities was
key to the cooperation needed to build and sustain large, complex societies.
In a series
of laboratory
experiments, the researchers found that antibodies against HSV - 1 remain in the trigeminal ganglion (a group
of nerve cells that receives signals from the eyes and face and is a
key site
of HSV infection) long after active virus infection is cleared, and that these maternal antibodies can travel to the fetal trigeminal ganglia.
It's the first
experiment to show that it's possible to send large amounts
of secure quantum data protected by a much shorter secret
key, the team reports August 12 in Physical Review A.
Published a month apart in PLOS Pathogens, the studies from Professor Ethan Bier's laboratory used a series
of experiments to identify
key pathways and mechanisms previously unknown or overlooked in the body's defenses.
These
experiments illuminated many
of the
key principles
of genetics.
This famous ability is a
key feature
of quantum reality and has been demonstrated in countless
experiments.
To find out more about the elusive particles and their potential links to cosmic evolution, invisible dark matter and matter's dominance over antimatter in the universe, the Department
of Energy's SLAC National Accelerator Laboratory is taking on
key roles in four neutrino
experiments: EXO, DUNE, MicroBooNE and ICARUS.
In a recent set
of experiments, psychologist Nilli Lavie
of University College London found that this bit
of gray matter holds the
key to the phenomenon known as change blindness, in which people overlook the obvious when their attention is challenged.
The second
key experiment showed the effect
of transferring activated T - cells from heart - attack mice to healthy mice.
The first
key experiment involved removing a specific subset
of activated T - cells from mouse models.
While 50 years
of inorganic fertilization did increase soil organic carbon stocks in a long - term
experiment in western Kansas, the practice seemingly failed to enhance soil aggregate stability — a
key indicator
of soil structural quality that helps dictate how water moves through soil and soil's resistance to erosion.
2 - D cell - culture and mouse
experiments also provided
key evidence
of the virus's modus operandi; although the rodent brain doesn't harbor the full contingent
of human neural stem cells, it has blood vessels and immune - system components that organoids lack.
And
of course, it's good to do
key experiments early on because if it doesn't work, I have several alternative plans that I'll be happy to discuss with you.
«One
of the
key strategies that worked in our
experiments is to treat dopamine neurons early in the toxic cascade with specific antioxidants that improve mitochondrial oxidant stress and lower oxidized dopamine,» Krainc said.
It was these qualities, which allowed diverse groups
of people from far - flung corners
of the world to connect,
experiment and invent, that were arguably the
key elements
of the explosive technological growth
of the past two decades.
Key to the success
of the oxygen
experiments was a state -
of - the - art atomic - force microscope, purchased by Prof. Diebold using proceeds
of her 2014 Wittgensteinpreis Award.
The treatment did a lot to prevent cell migration, a
key mechanism in metastasis, in
experiments on laboratory cultures (in vitro)
of cancerous human cells.
Perusing the literature, he found earlier
experiments that demonstrated a crucial part
of the amygdala known as the central nucleus contained links to the
key brain stem areas that control the autonomic functions involved in the fear response, like acceleration
of breathing and heart rate.
The team
of researchers, led by Nobel Prize - winning chemist John Polanyi, employed a combination
of experiment and theory to discover that the position
of the molecule on the catalytic surface is a
key factor in determining the rate at which particular bonds break.
«Playback
experiments between geographically isolated taxa provide
key data on how populations might perceive each other in terms
of «same» or «different» if they were in actual contact,» according to Louisiana State University's J.V. Remsen, an expert on Neotropical birds who was not involved in the research.
The
experiment adapted devices built to do a more standard form
of quantum cryptography known as quantum
key distribution (QKD), a scheme that generates random numbers for scrambling communication.
«Hundred million degree fluid
key to fusion: Scientists developing fusion energy
experiments have solved a puzzle
of why their million - degree heating beams sometimes fail, and instead destabilize the fusion
experiments before energy is generated.»
In a second
experiment, the team investigated whether the treatment caused changes in chemicals known to be involved in «long - term potentiation» (LTP)-- a type
of brain activity
key to memory formation.
One
key to the whole
experiment's success turns out to be the specific diatoms involved, which use silicon to make their shells and tend to form long strands
of cellular slime after their demise that falls quickly to the seafloor.
To move a major muon
experiment from Brookhaven to Fermilab, however, particle physicists decided that a
key piece
of equipment — the massive but fragile accelerator storage ring — should travel by barge on a 6 - week voyage down the U.S. Atlantic coast, around Florida, and up the Mississippi River.
In the new study, Srinivasan and her colleagues, first author Research Assistant Tallie Noble and graduate student Jonathan Stieglitz, used a series
of gene - blocking
experiments to identify some
of the circuit's
key elements.
In a
key memory
experiment in the study, mice brains were injected with beta - amyloid, whose increase is one hallmark
of Alzheimer's in humans.