Sentences with phrase «of key pathways»

It is expected that 90 per cent of all future jobs will require digital skills and it is estimated that the UK will need more than 1.2 million new technical and digitally skilled people by 2022 to satisfy future skills needs, computer science GCSE is one of the key pathways that young people can take.

Parsley helps to stimulate most of our key pathways of detoxification, including our bowels, our lungs, liver, kidneys and spleen.

Basically, there are a number of key pathways that regulate metabolism, but leptin and insulin signaling are really important.

Two new members of a key pathway responsible for pattern formation during vertebrate development have been identified.

«We spent over five years discovering and furthering our understanding of this key pathway associated with salt sensitivity since the presence of NBCe 2, and its effect on salt excretion has never been demonstrated in the human kidney,» said Carey, of UVA's Department of Medicine.

Not exact matches

The key is to know where you are in your pathway and what else lies in front of you.

Exercise could strengthen some of the pathways our brain uses to relay signals for recent events, or boost the size of certain brain regions that are key for learning and storing memories.

The stressor also activates key inflammatory pathways in peripheral blood cells and increases in levels of pro-inflammatory cytokines.

The Accountability Framework, an initiative being developed by a coalition of leading environmental and social organisations (including the Rainforest Alliance), will provide a clear pathway for companies on the sustainability journey — including key milestones and benchmarks to evaluate their progress.

Multiple Pathways The Partnership was a key advocate pushing for the New York state's Board of Regents to establish multiple pathways to graduation for high school sPathways The Partnership was a key advocate pushing for the New York state's Board of Regents to establish multiple pathways to graduation for high school spathways to graduation for high school students.

The introduction of the GCSE is also identified as a key educational reform, opening pathways for the majority.

Key brain regions have been identified by imaging studies, as have key neurochemical pathways bringing about the possibility of using drugs to block the nocebo effeKey brain regions have been identified by imaging studies, as have key neurochemical pathways bringing about the possibility of using drugs to block the nocebo effekey neurochemical pathways bringing about the possibility of using drugs to block the nocebo effect.

Stomach switch The key to turning pluripotent stem cells into stomach cells was a pathway of interactions that acts as a switch between growing tissues in the intestine and in the antrum, a part of the stomach near its outlet to the small intestine.

The elucidation of key steps in this biochemical pathway had won Calvin the 1961 Nobel Prize in chemistry; during his acceptance speech at the Nobel ceremony in December that year, Calvin previewed his paper on the entire pathway.

«New study of brain circuits finds key links to symptoms of depression: Altering distinct brain pathways found to aid symptoms such as social withdrawal and helplessness behavior.»

OMP - 54F28 (FZD8 - Fc) and a sister compound also developed by OncoMed, vantictumab (OMP - 18R5), are two of the first therapeutic agents targeting this key pathway to enter clinical testing.

OMP - 54F28 (FZD8 - Fc) is an antagonist of the Wnt pathway, a key CSC signaling pathway that regulates the fate of these cells.

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

Co-author Fred Reike, who specialises in retinal disease, says that quantum dots have great potential in this area because they directly affect ion channels, which play a key part in the signalling pathways of vision.

A particular enzyme in the pathway — phosphogluconate dehydrogenase (PGD)-- turned out to be key, enabling the conversion of glucose to metabolites that «can directly fuel tumor growth,» McDonald said.

«We identified the cytosolic protein Vms1 as a key component of a novel pathway termed mitoRQC that protects mitochondria from the toxic effects of such aberrant proteins,» explain the authors of the study.

She says mutations in key players of the mTOR pathway, a molecular pathway present and active in several types of cancer, have been identified in pNETs.

Kenneth Mann, a biochemist at the University of Vermont in Burlington, does not doubt that blocking these anticoagulant pathways will increase the production of thrombin, a key protein in clotting, but he does not think that these therapies will necessarily work for everyone.

Understanding what happens with the UPR in disease is key to illuminating the normal operation of this essential pathway — and to providing insights into the development of targeted therapies.

In addition, he touted the benefits of international research cooperation as a key pathway to innovation — a theme echoed by Moniz.

Published a month apart in PLOS Pathogens, the studies from Professor Ethan Bier's laboratory used a series of experiments to identify key pathways and mechanisms previously unknown or overlooked in the body's defenses.

Partly related to its function as a regulator of the immune response, the NF - kB pathway is also a key regulator of cancer progression.

The first study used fruit flies as an in vivo test system to reveal new evidence about the function of a key influenza protein called NS1, which has evolved to target molecular pathways in the host.

Interestingly, the let - 7 family of micro RNA affects several key genes that regulate glucose metabolism, called the PI3 / AKT / insulin pathway.»

Autophagy has emerged as a key pathway that cancer cells use to survive in the face of assault by chemotherapy and radiation; however, autophagy as a potential druggable mechanism in patients who become resistant to BRAF inhibitors has not been investigated.

They found that the compound reduces levels of a key protein — known as IkappaBzeta — in the IL - 17 inflammatory pathway.

Chloroplast, the compartment responsible for plant photosynthesis, is a key component of this signaling pathway.

These findings suggest that the effects of prostaglandin on serotonin signaling are key drivers of the emotional response to pain, implicating a pathway that may be targeted in future therapeutics for managing pain in chronic inflammatory conditions.

The retrograde response pathway is specific to the yeast used in the study and supplies key amino acids to the cell by changing the metabolic process of the mitochondria.

They were interested in one of the cell's key signaling pathways, the MAPK pathway, which helps control cell growth, embryonic development, and the maturation of oocytes into eggs.

«Early brain connections key to reading: Pathways that exist before kids learn to read may determine development of brain's word recognition area.»

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptors.

Sifting through this mountain of data, the scientists found three key genes that were altered by the NOTCH1 mutation and also acted as master regulators, turning off the critical pathways that normally prevent inflammation and calcification.

The molecular structure of the two key lipid components in the newly discovered signaling pathway are ceramide (right) and cardiolipin (upper left).

Environmental scientists and synthetic biologists have for the first time developed a set of key research areas to study the potential ecological impacts of synthetic biology, a field that could push beyond incremental changes to create organisms that transcend common evolutionary pathways.

«Using novel computational methods, we have pointed to new biological pathways that act in the brain to regulate overall obesity, and also to a different set of pathways related to fat distribution that regulate key metabolic processes,» says senior author Joel Hirschhorn, M.D., Ph.D., Concordia professor of pediatrics and professor of genetics at Boston Children's Hospital and Harvard Medical School, and co-director of the Broad Institute Metabolism Program.

In their new paper, Cheyette and his team examined the gene DIXDC1 — a key piece of the WNT signaling pathway that is active in tissues of the brain and interacts with DISC1, a gene implicated in schizophrenia, depression, bipolar disorder, and autism spectrum disorders.

«Our study is the first to associate this complex pathway of molecules, of which TGF β1 seems to be a key player, to astrocytes» ability to modulate inhibitory synapses,» says Flávia Gomes.

The team demonstrated that GPR158 affects key signaling pathways involved in mood regulation in the region of the brain called prefrontal cortex, though the researchers emphasized that the exact mechanisms remain to be established.

«Another interesting aspect of this work is that lncND appears to help regulate the key developmental pathway of Notch signaling.»

Geschwind, a professor in the Russell H. Morgan Department of Radiology and Radiological Science at the Johns Hopkins University School of Medicine and its Kimmel Cancer Center, and others at Johns Hopkins have been studying the experimental drug as a cancer treatment for over a decade because of its ability to block a key metabolic pathway of cancer cells.

More importantly, Choudhury and colleagues found that DAZAP1 directly links the regulation of gene splicing with the MAP kinase pathway — a key signaling pathway that controls cell proliferation.

By identifying the key pathways affected by age in mice we have a better idea of what to look for in humans.»

The key insight that emerged is that the experience of danger follows two pathways in the brain: one conscious and rational, the other unconscious and innate.

The mutations inhibited key molecules involved in insulin signaling (IIS) and the nutrient signaling pathway Target of Rapamycin (TOR).