Sentences with phrase «of key transcription factors»

ES cells can be described based on a characteristic morphology, the presence of cell surface markers such as SSEA - 1 and Pecam1, or the expression of the key transcription factors such as Oct4, Sox2, Nanog, and a number of ES cell - specific transcripts (ECATs)[4]--[6].

We have identified a number of key transcription factors that are deregulated during this process, and we are using this information to investigate mechanisms by which differentiation can be reprogrammed in tumour cells.

What are the direct targets of key transcription factors that regulate cardiogenesis and cardiomyocyte differentiation and how do they function in networks?

While the process usually proceeds in a one - way direction, artificially inducing the activity of key transcription factors can reprogram differentiated cells back into a stem - like state, a discovery honored with the 2012 Nobel prize.

Not exact matches

The investigators focused on studying the activity of AHR, a transcription factor that is known to play a key role in regulating inflammatory and immune responses, and the effects of two AHR ligands (ITE and FICZ).

In addition, when these transcription factors lose their function, terminal differentiation into the vascular endothelium (completion of differentiation) is completely suppressed, and genes that are key to differentiation into vascular endothelial cells as well as transcription factors that maintain the undifferentiated state are adversely induced.

In the March 24 issue of the Proceedings of the National Academy of Sciences they explain that they were able to crystallize a key protein called a transcription factor and work out its structure.

Shimon Sakaguchi and colleagues report that the transcription factor Foxp3 is a key regulatory gene for the development of regulatory T cells.

However, genome integrating viral vectors and oncogenic transcription factors are still key parts of many reprogramming schemes, and many early differentiation studies need to be confirmed using iPSCs generated using safer non-integrating viral vectors.

June 2009 - The X factors of stem cells Ian Chambers and Simon Tomlinson review the transcription factor and pluripotency story so far Transcription factors are key proteins in ctranscription factor and pluripotency story so far Transcription factors are key proteins in cTranscription factors are key proteins in cell identity.

A key transcription factor involved in expression of pro-inflammatory cytokines and senescence is Nuclear factor - kB (NF - kB) 24.

The STAT3, in turn, goes into the nucleus and it binds to a number of genes, and this is particularly happening in the hypothalamus and that we don't know all of the mechanisms, but this activation of the STAT3 transcription factor is key in exerting the leptin signal, and leptin action.

This transcription factor appears to be key to the loss of A9 subtype dopamine neurons of the substantia nigra in PD.

These experimental data establish the retromer complex as a key spatiotemporal regulator of IFNAR endosomal sorting and a new factor in type - I IFN - induced JAK / STAT signalling and gene transcription.

The project will test the hypothesis that the SOXC transcription factors have key roles in these cells, similar to those of SOX2 in pluripotent stem cells.

Searching for details on underlying mechanisms, the scientists found that tribbles was binding to ATF4, a «transcription factor» protein that regulates the creation of the key docking proteins.

The bromodomain containing protein 9 (BRD9) has been reported as a component of the switch / sucrose non-fermentable (SWI / SNF) brahma - related gene 1 - associated factor (BAF) complex, which plays a key role in chromatin remodelling and transcription control [1] although the precise biological role is unknown.

We then found that the transcription factors Smad1, Smad5 and Zeb2 were also experimentally validated targets of miR - 181a [30,31,34], which are key downstream regulators of BMP / GDF signalling [32,33,35,36].

The 1500 transcription factors (TFs) within the human genome perform a key role in determining the set of active genes within a specific cell, as well as the magnitude of activity.

Likewise, the expression pattern of cdx - 2, a key transcription factor in the trophoblast lineage, overlaps with that of Oct - 4, but within any blastomere, cdx - 2 expression bears no consistent relationship to that of Oct - 4 or nanog until after the trophectoderm lineage has been sorted [9].

Through a series of genetic analyses, we have constructed a hierarchical map composed of five transcription factors that define the key steps of proliferation, survival, differentiation, and hormone expression of the PVN and SON neurons during development.