The results suggest that evolution of resistance in independent populations
of killifish converges on the same target gene.
«One
of our killifish mutants recapitulates, but in a rapid manner, a human disease called Dyskeratosis congenita, which is due to deficits in a complex involved in maintaining the end of chromosomes, or telomeres,» says lead author Dr. Itamar Harel, a postdoctoral research fellow in genetics.
Some of the killifish mutants have already shown promise for studying aging and disease.
Not exact matches
Using Atlantic
killifish (Fundulus heteroclitus), the researchers examined whether mitochondrial - nuclear interactions alter the frequency
of alternative forms
of a gene that arise by mutation, called alleles, for over 11,000 nuclear DNA sequence variations within a population
of the fish with mixed ancestry.
In a new study, researchers at the University
of Miami (UM) Rosenstiel School
of Marine and Atmospheric Science examined how the interaction
of two genomes in animal cells — the mitochondrial and nuclear genomes — interact to affect adaptation
of the Atlantic
killifish to different temperatures.
Next, the authors compared their stickleback results to previously published opsin genes in two related species
of fish (bluefin
killifish and black bream), separated from sticklebacks by millions
of years, that had also adapted to blackwater and clearwater habitats.
Stanford University scientists have found a new middle ground with the development
of a genome - editing toolkit to study aging in the naturally short - lived African turquoise
killifish.
African turquoise
killifish live in temporary ponds
of water in Zimbabwe and Mozambique that disappear with the dry season.
«Fast aging and time machine: Genome
of the Turquoise
killifish sequenced.»
The findings, posted online in advance
of publication in the journal Environmental Science and Technology, are part
of an ongoing collaborative effort to track the impacts
of the Deepwater Horizon oil spill on Gulf
killifish populations in areas
of Louisiana that received heavy amounts
of oil.
The researchers have tracked the impact
of the oil on
killifish since the Deepwater Horizon spill occurred in April 2010.
The researchers collected Gulf
killifish from an oiled site at Isle Grande Terre, La., and monitored them for measures
of exposure to crude oil.
Whitehead said it is possible that some
of the healthier, less impacted
killifish could buffer the effects
of the spill for the population as a whole.
Other species that share similar habitats with the Gulf
killifish, such as redfish, speckled trout, flounder, blue crabs, shrimp and oysters — may be at risk
of similar effects.
Researchers will look next at whether the adaptation affects how the
killifish are able to respond to other kinds
of stressors in their environment, such as low oxygen levels.
The study found that female
killifish that avoid mating with males
of a closely related species also are less likely to mate with males
of their own species — if those males come from an unfamiliar population.
«Even though the specific molecular changes that are found in PCB - resistant tomcod and
killifish are different, in both species AHR2 seems to be one
of the genes — possibly the major gene — that is responsible for the resistance,» Hahn said.
While the
killifish themselves seem to be immune to the toxic effects
of the PCBs, they can still transfer contaminants up the food chain.
pipeline dredge reconstruction
of fringe marshes....6 x 12 precast concrete culverts to unblock tidal creeks... and use
of the amphibious Rolligon Ditcher Spreader to recreate tidal creeks and OMWM (
killifish reservoirs)