Sentences with phrase «of kinesin»

Control and gating of kinesin - microtubule motility on electrically heated thermo - chips.

Protein friction limits diffusive and directed movements of kinesin motors on microtubules.

His lab provided the first molecular descriptions of kinesin structure and organization, and has recently discovered important links between transport processes and diseases such as Alzheimer's disease and Huntington's disease.

Dense Core Vesicle Dynamics in Caenorhabditis elegans Neurons and the Role of Kinesin UNC - 104.

Volker Bormuth (Howard, MPG)-- «Optimized optical tweezers to study the mechanics of kinesin - 8: stepping, slipping, protein friction» (2009)

«The structure of kinesin - 5 is unexpected, and the implications are big — it allows us to target it, for example in various forms of cancer,» said Jawdat Al - Bassam, assistant professor of molecular and cellular biology at UC Davis, who led the project.

Members of the kinesin superfamily of motor proteins are essential for mitotic and meiotic spindle organization, chromosome segregation, organelle and vesicle transport, and many other processes that require microtubule - based transport.

Not exact matches

Although scientists have found dozens of different kinesins, each with its own job, they know little about how the minimotors work.

We demonstrated that β - arrestins mediate the activity - dependent interaction of Smo and the kinesin motor protein Kif3A.

Lawrence Goldstein and his colleagues at the University of California, San Diego (UCSD), reasoned that if they could find a molecule that halts kinesin function, they could learn more about when and how they work — and possibly design drugs to disable specific kinesins.

Cellular motors called kinesins drag cargo within cells — they tug recently separated chromosomes to opposite ends of a dividing cell, for example.

Things like HIV protease inhibitors, for example, or Kinesin - tubulin interactions do not appear to be covered by any of the subheads listed under these two headings.

This particular active material, originally developed at Brandeis University, borrows elements of cellular machinery, with bundles of rod - like microtubules forming the filaments, kinesin motor proteins acting as the engines, and ATP as the fuel.

Proteins called kinesins, for example, are natural nanomotors that support cellular functions such as mitosis (the chromosomal process that creates two nuclei from one parent nucleus) and meiosis (when the number of chromosomes per cell is reduced by one half).

A compound, adociasulfate - 2, was isolated from a marine sponge, Haliclona (also known asAdocia) species, that inhibited kinesin activity by targeting its motor domain and mimicking the activity of the microtubule.

His team found that, from its vantage point at the minus - end of an existing microtubule, Kinesin - 14 attaches to a second protein that is bound to the plus end of a growing microtubule.

A team of researchers led by Alipasha Vaziri, an associate professor and head of the Rockefeller's Laboratory of Neurotechnology and Biophysics, has found that a molecular motor, called Kinesin - 14, helps to guide the formation of a new microtubule along an existing one, and so directs the formation of bundles.

The researchers described how a protein called kinesin - 5 acts like a kind of molecular motor to help organize the mitotic spindle.

By shining a laser light on a microscopic - sized plastic bead attached to a pair of microtubules linked by kinesin - 5 molecules, the team tracked their activity and discovered that this force is a function of the microtubule overlap — the longer the overlap, the greater the force.

The study shows it takes a lot of counterforce to slow down a determined kinesin.

The base simulation will allow researchers to test more kinesins that move cargo from the nucleus to the outer limits of the cell and, eventually, dyneins, larger and more complex proteins that move cargo toward the center.

As many kinesin - 5 molecules work together directing microtubules, they become the governing force of the spindle formation.

«We believe that kinesin - 5 has the ability to coordinate the speed of microtubules and keep them from going too fast or too slow,» says Forth, likening the protein to a gear box in a car.

Other motor proteins, called kinesins and myosins, are much smaller and have specific functions, but dynein can turn its hand to a lot of different of functions,» Professor Knight said.

In this example, the leading kinesin (LK) carries most of the load, with motor heads (blue) activated by a neck linker (yellow) that connects to the stalk (red) and senses the presence of the cargo.

RESULTS: Here we report the identification of a de novo nonsense truncating mutation in one patient with SCZ, in kinesin 17, a synaptic motor protein.

Functional analysis of human microtubule - based motor proteins, the kinesins and dyneins, in mitosis / cytokinesis using RNA interference.

The Fragile Fiber1 Kinesin Contributes to Cortical Microtubule - Mediated Trafficking of Cell Wall Components.

A kinetoplastid - specific kinesin is required for cytokinesis and for maintenance of cell morphology in Trypanosoma brucei.

Molecular Basis for Specific Regulation of Neuronal Kinesin - 3 Motors by Doublecortin Family Proteins.

Inhibition of the motor protein Eg5 / Kinesin -5 in amyloid β - mediated impairment of hippocampal long - term potentiation and dendritic spine loss.

The human kinesin - 14 HSET tracks the tips of growing microtubules in vitro.

Regulation of endosomal membrane traffic by a Gadkin / AP -1 / kinesin KIF5 complex.

Kinesin - 1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei.

CENP - meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila.

Molecular Basis for Specific Regulation of Neuronal Kinesin - 3 Motors by Doublecortin Family Proteins % U http://www.sciencedirect.com/science/article/pii/S1097276512005503.

Alzheimer amyloid beta inhibition of Eg5 / kinesin 5 reduces neurotrophin and / or transmitter receptor function.

The kinesin - 8 Kip3 scales anaphase spindle length by suppression of midzone microtubule polymerization.

Vladimir Varga (Howard, MPG)-- «Characterization of Saccharomyces cerevisiae kinesin - 8 by single - molecule fluorescene microscopy» (2008)

Novel interactions of fission yeast kinesin 8 revealed through in vivo expression of truncation alleles.

Marko Storch (Howard, MPG)-- «Characterization of microtubule stability regulating kinesins in vitro and introduction of a high throughput technique for studying kinesins on the single molecule level» (2012)

Fluorescence imaging of single Kinesin motors on immobilized microtubules.

In addition to receptors, GRIP has also been shown to bind to KIF - 5, a kinesin motor protein that is crucial in the transport of AMPA receptors within the neuron (Setou et al 2002).

«George was one of the first biophysicists who married experiments and theory by developing computational models of a bewildering variety of molecular machines — kinesin motor, flagellar rotary motor, RNA polymerase and protein translocation motors, «one - shot» actin polymerization motor and «slime - gun» motor of bacterial gliding,» Magilner said.

The investigators showed that kinesin movement corresponds to traffic from the center of a nerve cell to its axonal tips — and a different motor in the squid's cytoplasm, which was subsequently identified as dynein, travels in the opposite direction.