Sentences with phrase «of kinetochore»

The monopolin complex regulates different types of kinetochore - microtubule attachments in fungi, ensuring sister chromatid co-orientation in Saccharomyces cerevisiae meiosis I and inhibiting merotelic attachment in Schizosaccharomyces pombe mitosis.

We therefore study functions of kinetochore proteins and spatio - temporal control of kinase / phosphatase signaling complexes, in particular those involved in attachment error - correction and the spindle assembly checkpoint.

Shugoshin enables tension - generating attachment of kinetochores by loading Aurora to centromeres.

Not exact matches

Biologists who study the mechanics of cell division have for years disagreed about how much force is at work when the cell's molecular engines are lining chromosomes up in the cell, preparing to winch copies to opposite poles across a bridge - like structure called the kinetochore to form two new cells.

Using two different force sensors to measure opposing forces inside dividing Drosophila cells, Maresca and colleagues at UMass Amherst have proposed that kinetochore fibers exert hundreds of piconewtons of poleward - directed force on kinetochores, settling the matter of how much force is brought to bear.

Identification of novel mitosis regulators through data mining with human centromere / kinetochore proteins as group queries.

Maize NDC80 is a constitutive feature of the central kinetochore.

Dynamics of CENP - N kinetochore binding during the cell cycle.

Structure of the MIS12 complex and molecular basis of its interaction with CENP - C at human kinetochores.

CENP - meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila.

Insights from biochemical reconstitution into the architecture of human kinetochores.

Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p.

Pivoting of microtubules around the spindle pole accelerates kinetochore capture.

Ipl1p - dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.

Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle.

Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin.

Modular elements of the TPR domain in the Mps1 N terminus differentially target Mps1 to the centrosome and kinetochore.

For this, it has evolved a surveillance mechanism (the spindle assembly checkpoint) that monitors the attachments status of each individual kinetochore to spindle microtubules (Figure 1).

Latham JA, Chosed RJ, Wang S, Dent SY (2011) Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination.

Kinetochores are extremely complex assemblies of > 100 proteins in hundreds of copies, bound to centromeric DNA sequences.

He completed his master's in biotechnology at the University of Pennsylvania, where he worked in Michael Lampson's lab studying microtubule — kinetochore dynamics during mitosis.

Motor - independent targeting of CLASPs to kinetochores by CENP - E promotes microtubule turnover and poleward flux.

DNA was stained with DAPI (chromosomes, blue): Chromosomes interact with microtubules constituting mitotic spindle via kinetochores assembled on centromere region of chromosomes.

Csm1 presents a conserved hydrophobic surface patch that binds two kinetochore proteins: Dsn1, a subunit of the outer - kinetochore MIND / Mis12 complex, and Mif2 / CENP - C.

For a post-doc, Corbett joined the lab of Stephen Harrison at Harvard Medical School with the intention of studying kinetochores, enormous protein assemblies that control the motion of chromosomes during cell division.

Instead of focusing on the mitotic kinetochore, Corbett decided to focus, unconventionally, on meiosis.

In Harrison's lab, Corbett solved the structure of monopolin, a complex that binds kinetochores in meiosis I to modify their behavior.

Such aspects may include meiotic control of DSB formation, kinetochore biology, chromatin organisation, suppression of genomic parasites and epigenetics.