Sentences with phrase «of laboratory trial»

In a series of laboratory trials, mice given BU10119 demonstrated behaviours consistent with providing antidepressant - like effects.

Not exact matches

The Chinese government financed nationwide studies into cockroaches» medical value that, after more than two decades of laboratory investigation and clinical trials, had discovered or confirmed dozens of disease - fighting proteins and biochemical compounds with huge potential value in medicine.

'' [M] oving our work from the laboratory to the field is not only an important milestone for our group of biologists, engineers, and automation experts, but it's also a critical step in bringing our long - term vision to reality,» Verily scientist Jacob Crawford wrote in a blog post announcing the trial.

Primarily, this investment will see a doubling of office space with increased storage facilities and the development of a new purpose - built laboratory for Research and Development (R&D) with three state - of - the - art pilot plants, which will test and trial pre - and post-treatment liquid and solid organic waste streams, to ensure optimal anaerobic digester performance.

Spanning an overall area of 2,200 m2 at the company's headquarters in Hamburg, the Center accommodates state - of - the - art pilot plants, equipment for the refinement of milled grain products, a professional kitchen and up - to - date baking technology for application - related trials, as well as a laboratory where products can be analyzed.

The laboratory includes several instruments for analyzing and creating different packaging and customers can make use of the form, fill, seal machine and thermosealers in the trial area.

Our highly skilled technicians combined with our laboratory - scale processing equipment reduce the need for large plant trials and accelerates the development of your product and speed to market distribution.

In science news around the world, eastern Asia is experiencing an unprecedented urbanization boom, the European Commission announces a plan to create a unified energy market for the European Union, an external review of the University of Minnesota's clinical trials procedures says the university didn't adequately protect its most vulnerable subjects, a new data repository of the world's oldest fossils is launched, and the Argonne National Laboratory's 24 - year - old Ask A Scientist service closes its virtual doors.

With each step in his laboratory experiments, the challenges got harder and more complicated, but because of the rooks» understanding of cause and effect, they produced solutions without resorting to trial and error.

«It's taken years of trial and error, making educated guesses and taking baby steps to finally produce functioning human muscle from pluripotent stem cells,» said Lingjun Rao, a postdoctoral researcher in Bursac's laboratory and first author of the study.

The objective of Pocket is to go beyond a mere laboratory prototype instrument, as during the final year of the project, Pocket will organize field trials in Africa and India.

«Next steps are to further explore this possibility in human trials in order to assess if it will help patients, but these two drugs make sense from a variety of studies and we find that they act together through multiple mechanisms to control cancer growth in the laboratory.»

The design of such antennas can still be a largely trial - and - error affair, with technicians moving elements from place to place in the laboratory as you might move your own body in order to pull in a weak broadcast.

Many of the studies conducted are first - in - human trials of experimental drugs or drug combinations that have shown promise in laboratory studies.

Working with the laboratory of Jeffrey Winkler, PhD, the Merriam Professor of Chemistry at the University of Pennsylvania, the team now hopes to develop optimized activators — or «agonists» — of the GPER and PAQR7 receptors, for eventual testing in human clinical trials.

As he works to better understand the biology of neratinib - induced Ras inhibition, Dent hopes his laboratory findings can be validated in clinical trials testing a combination of neratinib and valproic acid in patients with afatinib - resistant NSCLC.

I've run certain clinical trials but mostly at this point partner with some of my clinical colleagues to test the hypotheses generated in the lab in the clinic, in actual patients, and then actually try to analyze tumors from those patients to see whether the patterns that we identified in the laboratory in fact hold true in patients.

The mobile suitcase laboratory will enter a field trial in Guinea in collaboration with the Institut Pasteur de Dakar, Senegal, the Public Health Institute of Guinea, the University of Stirling, Robert Koch Institute, and TwistDx Ltd..

When projects on the scale of a nuclear power station or THORP are concerned, or the release of genetically modified organisms into the environment, to give another example, it is not possible to model them fully in the laboratory using traditional trial - and - error methodology.

This program integrates laboratory studies, clinical trials, and comprehensive molecular analyses of cancers to pioneer individualized therapies.

That trial centers on a phone call Bertolaso made to a local official in setting up the commission's meeting, in which he said he was sending the experts to L'Aquila on a «media operation» to reassure the public and «shut up» a technician in the nearby Gran Sasso nuclear physics laboratory who had allegedly made a series of alarming predictions of imminent strong earthquakes.

But this is early laboratory research and the next stage is for clinical trials to confirm whether resveratrol has the same effects in people at high risk of bowel cancer.»

Dr. Sharma is the principal investigator of multiple immunotherapy trials and performs extensive laboratory studies on patients» samples to gain insights regarding mechanisms and pathways involved in antitumor responses.

Using a novel synthetic platform for creating vaccines originally developed in the laboratory of David Weiner, PhD, a professor of Pathology and Laboratory Medicine from the Perelman School of Medicine at the University of Pennsylvania, a team led by his colleagues at the Johns Hopkins University School of Medicine, has successfully eradicated precancerous cervical lesions in nearly half of the women who received the investigational vaccine in a clinilaboratory of David Weiner, PhD, a professor of Pathology and Laboratory Medicine from the Perelman School of Medicine at the University of Pennsylvania, a team led by his colleagues at the Johns Hopkins University School of Medicine, has successfully eradicated precancerous cervical lesions in nearly half of the women who received the investigational vaccine in a cliniLaboratory Medicine from the Perelman School of Medicine at the University of Pennsylvania, a team led by his colleagues at the Johns Hopkins University School of Medicine, has successfully eradicated precancerous cervical lesions in nearly half of the women who received the investigational vaccine in a clinical trial.

There will be additional needs for scientists (Ph.D. and medical) with bench experience to maintain the anticipated mushrooming of central clinical trial laboratories.

The therapy was found to have an acceptable safety profile in all patients, with no clinical or laboratory signs of systemic cytokine release syndrome, a potentially serious toxicity that has been observed in other CAR trials.

Boston Children's Hospital has offered non-exclusive licenses to for - profit entities on a patent developed by Orkin's laboratory regarding BCL11A, a genetic switch regulating hemoglobin production that is expected to form the basis of clinical trials for gene therapy and gene editing for sickle cell disease and thalassemia.

«After a lot of trials, we managed to find a reaction that works very well at room temperature and ambient pressure,» said CMI and Ames Laboratory scientist Igor Slowing.

Despite the urgent need, almost all clinical trials of neuroprotective therapies to date have failed to translate from the laboratory to the clinic, according to the RBC research team.

In human trials, researchers remove some of patients» T cells through a process similar to dialysis and then engineer them in a laboratory to add the gene for the CAR so that the new receptor is expressed in the T cells.

As nanotechnology to ferry drugs to their destinations is tested in both the laboratory and in clinical trials, scientists have made a surprising discovery about the kinds of nanoparticles that might be most effective for eventually transporting a number of different cancer - fighting therapies throughout the body.

A potential new antidepressant developed by University of Bath scientists has shown promise in laboratory trials in mice.

Frédéric Revah, CEO of Genethon, the laboratory of the AFM - Telethon and the trial sponsor, said «These first results of our clinical trial for the treatment of Wiskott Aldrich syndrome are very encouraging.

We need studies like this to find out how the two are intertwined and hopefully find the right formula to help prevent Alzheimer's disease,» said Dr. Rong Zhang of UT Southwestern, who oversees the clinical trial and is Director of the Cerebrovascular Laboratory in the Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, where the Dallas arm of the study is being carried out.

Following the findings of Associate Professor Phipps» laboratory tests, Dr Ferreira is now conducting clinical trials, treating patients who have increased IL - 6 receptor levels with the rheumatoid arthritis antibody treatment.

In a meeting sponsored by the National Cancer Policy Forum of the National Academies» Institute of Medicine in Washington, D.C., Fan and 15 other experts in the field described the benefits of using pet dogs with naturally occurring (rather than laboratory - induced) tumors in early cancer drug trials.

Laboratory cage trials with a strain of IIV type 6 and Nosema ceranae confirmed that co-infection with these two pathogens was more lethal to bees than either pathogen alone.

Franziska Michor (Dana - Farber Cancer Institute)-- Research done at the computational biology and bioinformatics laboratory of Dr. Michor has led to the first clinical trials based on the evolutionary mathematical modeling of cancer.

That's where these findings will be directly implemented in additional research, and also in the context of clinical trials,» said Douglas A. Levine, M.D., head of the Gynecology Research Laboratory at Memorial Sloan - Kettering Cancer Center, New York, and a co-leader in the study.

Trials reported findings from different laboratory studies and at varying intervals of repeated measurements in time.

Many of these novel cancer immunotherapy approaches, which originated from basic science research in CCIR laboratories, are now being explored as new treatment modalities in patients, with a significant number advancing through clinical trials towards FDA approval.

iBET's infrastructure comprises 16 laboratories fully equipped with state - of - the - art technology (70 m2 each), including a BSL2 laboratory for working with viruses; a GMP Analytical Services Unit certified by the INFARMED (the Portuguese medicines authority, EMA Portuguese branch) and by DGAV (the Portuguese veterinary authority) for quality control and batch release of human and veterinary pharmaceuticals, biopharmaceuticals as well as experimental new drugs; a GMP Mass - Spectroscopy Unit that provides state - of - the - art MS services to the scientific community and Industry; a 2600 m2 bio-pilot plant supporting production and purification of proteins ATMPs and vaccines from bench top to 300 L scale and privileged access to GeniBET Biopharmaceuticals, an iBET spin - off producing ATMPs under cGMP certification for phase I / II / III clinical trials.

Findings from basic research, such as studies of cancer cells in the laboratory, can ultimately define research questions to study in humans, such as helping to identify drugs to test in clinical trials.

In order to obtain the comprehensive designation, which is the highest ranking the National Cancer Institute (NCI) gives, a center must meet strict criteria that include a strong core of basic laboratory research in several fields, the ability to translate those research findings into therapies that can one day be used to treat patients, a program of high - priority clinical trials, and a commitment to community service and outreach activities related to cancer prevention and control.

By participating in these trials, patients have access to the best of what is coming out of the world's cancer laboratories, in a holistic approach that matches the appropriate treatment to each individual patient's needs.

The data from extensive laboratory studies on correlates of risk of HIV infection will be used in one aspect of the clinical trial design.

Included among the numerous recipients of Mr. Sanford's gifts, that total more than one billion dollars, are: the Edith Sanford Foundation for Breast Cancer that was created in 2012 by a gift of $ 100 million in honor of Mr. Sanford's mother who died of breast cancer when he was four years old; the Sioux Valley Hospitals and Health System, which renamed itself Sanford Health in 2007, in recognition of a $ 400 million gift; a $ 125 million gift in 2014 to establish Sanford Imagenetics, a program that will integrate genomic medicine into primary care for adults; the University of California San Diego which received a $ 100 million gift for the creation of the Sanford Stem Cell Clinical Center in 2013 to accelerate the translation of stem cell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative Medicine.

And importantly, we're combining therapeutic trials with testing these new biomarkers out of the laboratory, in humans, to ask if the biomarkers can let us detect disease or improvement even faster.

Now, in a study published in Stem Cells, the laboratory of Seung Hyun Kim (Hanyang University, Seoul, Korea) report on an open ‐ label, single ‐ arm, investigator ‐ initiated trial to identify biological markers of MSCs to predict response to in patients with ALS [3].

Charbel Moussa, director of Georgetown's Laboratory of Dementia and Parkinsonism, and Fernando Pagan, director of Georgetown's Movement Disorders Program, led the trial, which was supported by the Georgetown - Howard Universities Center for Clinical and Translational Science.