Sentences with phrase «of large numbers of gene»

The system can yield dose - response curves for candidate drugs, screen the phenotypes of large numbers of gene mutations, or execute complex custom protocols for completely new experiments.

She also says that other recent work confirms that it's possible to compute the impact of large numbers of genes using simple arithmetic.

«This is the first indication that DISC1 regulates the activity of a large number of genes, many of which are related to synapses,» Ming says.

In the case of IGF2BP3 and B - cell leukemia, the overall effect of the RNA binding protein is to promote the proliferation of B cells by shifting the expression of a large number of genes, Sanford said.

Study coauthors Rammohan Rao of the Buck Institute for Research on Aging and Dale Bredesen of the Buck Institute and UCLA «have provided evidence for a novel — in fact, radical — idea: that ApoE somehow gains access to the nucleosol and acts as a conventional transcription factor, influencing the expression of a large number of genes,» Steven Barger, who studies neurodegenerative disease at the University of Arkansas for Medical Sciences and was not involved in the study, wrote in an email to The Scientist.

Ikaros's function is to bind DNA and regulate the activity of a large number of genes in cells.

Our results support the well - known fact in different mammalian species that IVC increases the transcription at blastocyst stage of a large number of genes, suggesting a decrease in repressive epigenetic marks [7, 44].

In - silico analysis can yield important insights into this aspect, facilitating comparison of two or more classes of genes comprising of a large number of genes within each group.

Not exact matches

True supertasters have both a large number of papillae AND a highly functional TAS2R38 gene.

A large number of genes previously not linked to developmentally - regulated neuronal death or neurodegenerative pathologies were identified.

A large number of genes involved in nervous system development and function were also deregulated.

This likelihood is quantified as the «heritability,» a number between 0 and 1, where a larger number implies that it is more likely that the shape of the face is controlled by genes.

«Our new data is scientifically important because ataluren restores activity to genes inactivated by nonsense mutations, and as a result, it has the potential to do so much for a large number of very complex genetic disorders,» Jacobson said.

Based on and expanding Ensembl's existing EnsemblCompara Gene Trees pipeline, the GeneSeqToFamily workflow removes many complex prerequisites of the process, such as having to use the command line to install a large number of separate tools, by converting the whole process into Galaxy; a much simpler platform to use.

The researchers now are studying some of the master genes to determine whether modifying them also causes changes in large numbers of other genes.

A clue emerged last year when researchers discovered that BRCA1 has an above - average number of fragile stretches of DNA called «Alu repeats,» which would make the gene susceptible to losing large chunks of DNA.

Correspondingly, a large number of genes with no direct role in tumor progression also are deleted as a result of their proximity to tumor suppressor genes.

By studying infected cells grown in a laboratory, the team found that a large number of CMV's genes help it hide from the immune system by allowing it to destroy many of the proteins produced by the body during virus infection and preventing them from activating immune cells to destroy the virus.

1982: In the early 80s, scientists realize that retroviruses have tremendous potential to deliver genes stably into large numbers of cells, and start producing lab - safe versions.

The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.

If cells were infected with an influenza A mutant lacking NS1, they proceeded to produce large number of the molecular complexes required for RNAi, which include a protein called Argonaute that slices through the target gene.

«A study covering a large number of subjects, like the one in 2015, makes it possible to identify the relevant genes across the entire population; but their variations have only a limited impact on individuals.

Pinker says that the findings are a first step in demonstrating that intelligence relies on large numbers of genes, each with a tiny effect, rather than on single genes that have moderate or large effects, but which are so rare that none has yet been identified.

They identified three genes (FANCL, VRK2 and BCL11A) associated with large numbers of accelerated regions of evolution.

Although there is no direct test yet, women in some families with large numbers of cases can be tested for known genetic markers that are inherited alongside the gene.

«The idea that you could get a very large number of complex genes synthesized and delivered in a FedEx package is something that was not practical just a decade ago,» says Steve Evans of Dow AgroSciences.

«It's very possible that other researchers and clinicians could use this type of gene editing to explore ways to cure a large number of diseases.»

We identified a large number of such events in critical cancer genes.

But you asked me right, the importance of gene duplication; most — I say, most, [which] is a rough number — but a very large number of the genes that carry out functions in our body are parts of [the] family of the genes, members of [the] family of the genes that have expanded by gene duplication.

Neanderthal genetic material is found in only small amounts in the genomes of modern humans because, after interbreeding, natural selection removed large numbers of weakly deleterious Neanderthal gene variants, according to a study by Ivan Juric and colleagues at the University of California, Davis, published November 8th, 2016 in PLOS Genetics.

«The large number of genes makes it less likely that one solution to beat obesity will work for everyone and opens the door to possible ways we could use genetic clues to help defeat obesity,» she says.

A peek at tardigrades» genetic diaries may dispel a rumor about an amazing feat the tiny creatures were supposed to perform: borrowing large numbers of genes from other organisms.

The «large number of unknown genes argues that our standard tools of biological study are very limiting,» Venter asserts.

A comprehensive genomic analysis of Wilms tumor — the most common kidney cancer in children — found genetic mutations involving a large number of genes that fall into two major categories.

Analyzing large numbers of cells, each with slight differences in their DNA, for their ability to carry out a behavior or survive a drug treatment can reveal the importance of particular genes, or sections of genes, in those abilities.

Because of the urgent needs of a large number of cancer patients, most of these gene therapy trials are directed against cancer.

The scientific community uses knockout mice to analyze basal phenotypes (the appearance of genetic characteristics) to analyze the function of such a large number of genes.

Participating in large international research projects, Dr Harbo and colleagues have helped to identify a number of new risk genes for MS and MG.

A large number of rare childhood diseases stem from mutations in genes that play an essential role in lipid synthesis.

However, because of the extremely small effect size of the BD risk (i.e., odds ratio ~ 1.2), Prof. Nakao Iwata says, «a large number of risk genes are still unidentified.

In particular, the comparison of gene sequences in large numbers of patients and controls will be a key step in strategies for disease gene identification.

Now, he and his colleagues are studying larger numbers of cave fish with variation in these behaviors, in the hopes that they can tease out which versions of which genes are associated with the extremes of these behaviors.

The new study is the largest of its kind, the researchers say; previously, the largest such study considered less than half the number of genes and less than one - third the number of species.

Because many of the genes influencing facial morphology are likely to have small effects, successfully mapping a large number of these genes will require much greater sample sizes and a more comprehensive approach to quantifying facial features of interest.»

So, if a gene lies within a gene - dense, low - recombination region, then this means that a much larger number of progeny from crosses must be examined to find those that derive from rare recombinational events that separate the desired new allele from undesirable forms of neighboring genes.

«However, we hadn't realised there may be a large number of genes fueling the interactions, or that these types of genes hamper a species» ability to adapt to new conditions.»

«We observed that a large number of genes were involved in pathways related to wound healing, immunity, and metabolism, and this is consistent with the idea that the earliest stages of domestication may involve adapting to highly crowded conditions,» said Mark Christie, lead author of the study.

In particular, the protein enhances the expression of a well - characterized oncogene called MYC, which in turn regulates a large number of genes involved in cell proliferation.

Most researchers believed that the Y chromosome of cattle would be similar to the Y chromosome of other mammals, which does not have a large number of genes and is considered mostly transcriptionally inactive, Liu said.

That ancestor suffered a process known as «gene decay,» where over a long period of time and multiple generations, a large number of genes mutated, became non-functional, and eventually disappeared.