Sentences with phrase «of lead toxicity»

And while it's not a common issue in dogs and cats, cases of lead toxicity do happen, so the ASPCA Animal Poison Control Center offers this primer.

Common signs of lead toxicity in adults include high blood pressure, constipation, joint and muscle pain, decline in memory, and headache.

Expectant moms shouldn't even help scrape off the old paint, as the risk of lead toxicity remains high for all homes built before 1976.

Not exact matches

This is primarily the result of a lack of understanding and it's very damaging to a company culture — leading to contagious toxicity, resentment and even animosity.

Clean eating is def a key of the puzzle, as exercise, but also toxicity removal (mold infection, heavy metals toxicity, esp fillings to remove in our mouths: 90 % of them include neurotoxins mercury and / or lead!

I lead by example, dedicated to health and wellness and to helping educate others on the subject of chemical toxicity in particular and the impact of that on our, our children's and the planet's health.

You should also make sure that your child has all of his or her well - child visits on time to screen for any possible delays that could be caused by lead toxicity.

No harsh chemicals were used in the production of this portable crib mattress as it has passed all flammability, lead, and toxicity tests, so it is incredibly safe as well.

Like the phrase «mad as a hatter,» which was caused by mercury toxicity, another, «crazy as a painter,» referred to the toxic effects of lead in paint.

Anti-aging cream that contains high levels of retinoids can lead to vitamin A toxicity.

Since there is not enough research on the effects of ammonia on babies in the womb, but high amounts could lead to toxicity of a mom's body, it is best to err on the side of caution.

PFOA, as well as PFOS and all the PFCs, create a very difficult situation for communities affected, as it bioaccumulates in the body, it doesn't biodegrade, and its toxicity has led to several of these chemicals being linked to very serious health concerns, including cancer.

Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.

The theory led to a flurry of investigations into the possible role of biomagnified BMAA toxicity in neurodegenerative disease.

A team led by the Department of Energy's Oak Ridge National Laboratory has identified a novel microbial process that can break down toxic methylmercury in the environment, a fundamental scientific discovery that could potentially reduce mercury toxicity levels and support health and risk assessments.

Dr Noel added: «What is really exciting about this breakthrough is that largely reducing the toxicity of the solvent hasn't led to a reduction in the efficiency of the material in harnessing solar energy.»

«Since cocaine works exclusively to modulate autophagy versus other cell death programs, there's a better chance that we can develop new targeted therapeutics to suppress its toxicity,» says Maged M. Harraz, Ph.D., a research associate at Johns Hopkins and lead co-author of the paper.

In one case, liver toxicity led to closure of the trial, while the other combination appears well - tolerated as the trial continues.

For most available T cell immunotherapies, T cells (which play a central role in defending the body against illness) are engineered to recognize and eliminate tumors, but their activity is not specifically controlled, leading to toxicity and unwanted side effects in patients as a result of inflammation or in some cases suboptimal response to treatment.

«Environmental science actually shares a common goal with drug makers: to improve the prediction of chemical toxicity,» says Dr. Allan Peter Davis, lead author of a paper on the work and the biocuration project manager of the Comparative Toxicogenomics Database (CTD) in NC State's Department of Biological Sciences.

Releases of lead to the environment are now tightly controlled because of the metal's toxicity.

Attacking the perennial problem of systemic toxicity from typical chemotherapy treatments, Dartmouth investigators, led by Barjor Gimi, PhD, have engineered therapeutic cells encapsulated in nanoporous capsules to secrete antitumor molecules from within the tumor.

In fact, «it also opens the way to using drugs that block the NMDA receptor — another regulator of neuronal excitability leading to hypersensitivity in painful processes — and to avoiding the serious side effects resulting from their high toxicity — sedation, nausea, dissociative reactions, behaviour modification, etc. — nowadays induced by these drugs,» argues Hipólito.

«This study, one of only a few large studies to have follow - up beyond five years, demonstrates that patients who have head and neck cancers and who are being treated with radiation therapy alone have improved local - regional control and no increase in late toxicity when radiation therapy is delivered twice a day in two smaller doses which we call hyperfractionation,» said Jonathan J. Beitler, MD, MBA, FASTRO, lead author of the study and professor of radiation oncology, otolaryngology and hematology / medical oncology at the Winship Cancer Institute of Emory University School of Medicine in Atlanta.

Determination of toxicity and side effects; first studies on animals (rodents and nonrodents) that may lead to the leading structure.

Some of the PCBs are not broken down in this way, and their continued stimulation of AHR2 disrupts cellular functions, leading to toxicity.

MacCoss and Baillie (p. 1810) outline how the synthesis of more effective analogs of lead compounds now takes many cues from the more readily obtained data on bioavailability and toxicity.

In the meantime, Takebe and the rest of the team, led by Hideki Taniguchi, also a stem - cell biologist at Yokohama City University — who are collaborating on the project with researchers at Sekisui Medical, a biotechnology firm based in Tokyo — hope that his liver bud could be useful for toxicity testing in drug screening, for which bile ducts are not needed.

They can also induce responses against normal tissue antigens, leading the immune system to attack normal tissues and cause toxicity in a subset of patients.

Combining their analysis with written accounts of old outbreaks, the team defined six stages in the evolution of the modern strain that led to its toxicity and its ability to spread, they report this week in the Proceedings of the National Academy of Sciences.

«We found that certain structural features of the TAML activators led to a higher degree of toxicity.

«Cadmium is a very important industrial metal, but exposure to it results in accumulation in the food chain, leading to toxicity in animals and humans,» says project leader Dr Christopher McDevitt, Senior Research Fellow and Deputy Director of the University's Research Centre for Infectious Diseases.

Further experiments in yeast and mice along these lines led Lindquist to propose a new, unifying hypothesis to explain the origin of the human prion disease and the mechanism of its toxicity.

The use of these chemo - free drugs allowed us to obtain good results in relapse / refractory setting, in particular in Hodgkin disease, with a good toxicity profile,» said lead study author Ombretta Annibali, MD, PhD, who is with the Department of Hematology at University Campus Bio-Medico in Rome, Italy.

Favorable responses with minimal toxicities in monotherapy trials have led to the first melanoma studies of T - VEC in combination with the cytotoxic T - lymphocyte — associated antigen 4 inhibitor ipilimumab and, separately, with the programmed death 1 — blocking antibody pembrolizumab.

In fact, short term treatment of patients with amiodarone leads to a significant decrease in the patient's serum TNFα concentrations while paradoxically the amiodarone toxicity is exerted through TNF - mediated apoptotic pathways [41].

Most people would think that a book about the toxicity of the elements arsenic, antimony, mercury, lead and thallium would be fairly heavy going, but this book reads more like a novel than a chemistry text.

«In both models, we found that neither IBs nor kinase activity were the direct causes of cellular toxicity leading to neuronal death,» said Dr. Skibinski, who was the paper's lead author.

Acute myeloid leukemia (AML) is the leading cause of leukemia mortality in the United States.1 Curative treatment involves intensive induction chemotherapy, before proceeding to either consolidation chemotherapy or allogeneic stem cell transplantation based on the patient's risk for relapse.2 This approach has been employed for > 4 decades and, although most individuals achieve complete remissions with front - line therapy, 3 the majority of patients ultimately relapse with drug - resistant disease, and overall survival rates remain disappointingly poor.4 The limited ability of many patients to tolerate the intense chemotherapy - based treatments, in particular hematological toxicity, further contributes to the poor outcomes noted in this disease.

The result is higher levels of acidity and toxicity in the body, which can lead to plenty of unwanted illnesses and diseases.

«Past studies of this kind have essentially assumed that all PM 2.5 particles have the same toxicity, irrespective of their source,» lead investigator George Thurston, a professor of population health and environmental medicine, said in a Langone news release.

Toxicity also leads to the suppression of parathyroid hormone, which regulates calcium homeostasis.

Some professionals claim that this type of folic acid may even cause a build - up in the body leading to toxicity.

Heavy metal toxicity in the bloodstream can lead to feelings of forgetfulness, drowsiness and even confusion and many patients have experienced great relief from chelation treatments.

If you are not careful in using it, the high dosage of vitamins can lead to vitamin toxicity.

Second, Warfarin, a vitamin K inhibitor, produces a toxicity profile almost identical to that of vitamin D, but does not increase serum calcium levels.81 Third, one group used vitamin D to produce calcium deposition in the kidneys of chickens at doses that did not lead to hypercalcemia.104 This finding is consistent with a case report of four post-menopausal women who were taking undetermined doses of vitamin D without their knowledge in the form of supplements that appeared to be contaminated with large amounts of vitamin D2: these patients had abnormally high vitamin D levels, three times the calcium in their urine as is normal, and appeared, albeit inconclusively, to have associated bone loss.

Yet none of these subjects had hypercalcemia.105 Taken together, these data suggest on the one hand that blood levels of calcium can become elevated without leading to toxicity, and on the other, that toxicity can occur even in the absence of elevated calcium.

In addition, mild cases of potassium toxicity can give rise to symptoms of muscular weakness, tingling and temporary paralysis, while severe toxicity leads to an abnormal heartbeat that can result in cardiac arrest.

Too much sugar can lead to tooth decay, liver toxicity and even increase your risk of a heart attack.

Soy consumption can also lead directly and indirectly to heavy metal toxicity — directly, because soy products are often processed or packaged in aluminum or processed with fluoridated water, and indirectly, because soy foods contribute to low levels of cysteine, zinc, pantothenic acid and other factors needed for detoxification.