Sentences with phrase «of lean mice»

The knee cartilage of obese mice who ate the oligofructose supplement was indistinguishable from that of the lean mice.

Macrophages in the adipose tissue of lean mice were uniformly small, isolated, and widely dispersed among the adipocytes.

«The nondigestible compounds in the Granny Smith apples actually changed the proportions of fecal bacteria from obese mice to be similar to that of lean mice,» Noratto said.

Scientists reached this conclusion by transferring microbes from bypass - treated obese mice to a group of lean mice raised in sterile conditions that left them with no intestinal bacteria at all.

Not exact matches

To find out what was going on in the microbiomes of four sets of differently shaped identical twins, researchers transferred some gut bacteria from a lean (human) twin to a sterile mouse: one with no foreign bacteria at all.

«How obesity dulls the sense of taste: Obese mice had about 25 percent fewer taste buds than lean mice in study.»

In another animal microbiome experiment, Jeffrey Gordon, a biologist at Washington University in St. Louis, took a suite of microbes from the guts of both obese and lean mice and transplanted them into the guts of microbe - free mice.

The mice that received the microbiomes of the obese mice gained significantly more weight than did the mice with the lean - mouse microbiomes.

These mice lived just as long as semi-starved lean mice, even though they had at least four times the body fat of normal mice.

In the mice that consumed either type of tea extract, there was less of the type of bacteria associated with obesity and more of the bacteria associated with lean body mass.

In this study, he exposed lean, brown - furred female mice to 50 milligrams of BPA per kilogram of body weight daily, and the next generation was transformed: More of them were fat, with blond fur.

«Importantly, we found that blocking the actions of the endocannabinoids with pharmacological inhibitors of cannabinoid receptors in the periphery completely normalized food intake and meal patterns in western diet - induced obese mice to levels found in control lean mice fed standard chow.»

«This is the first study to show that current strategies to bolster the effectiveness of flu vaccines protected lean mice from serious illness but fell short of protecting obese mice from infections,» said corresponding author Stacey Schultz - Cherry, Ph.D., a member of the St. Jude Department of Infectious Diseases.

Separate groups of germfree mice were colonized with uncultured fecal microbiota from each member of four twin pairs discordant for obesity or with culture collections from an obese (Ob) or lean (Ln) co-twin.

Cohousing mice harboring an obese twin's microbiota (Ob) with mice containing the lean co-twin's microbiota (Ln) prevented the development of increased body mass and obesity - associated metabolic phenotypes in Ob cage mates.

Moreover, obese - phenotype mice were invaded by members of the Bacteroidales from the lean mice, but, happily, the lean animals resisted invasion by the obese microbiota.

By comparing the behavior of XBP - 1s in the obese mice with that in lean, healthy ones, he discovered an inflammatory protein that modifies XBP - 1s in healthy animals so it can be shuttled into the nucleus.

Associate Professor Amanda Sainsbury - Salis expressed surprise at the impact of the Y6 gene deletion on mice, commenting «I find it amazing that one gene, which is expressed in the small part of the brain that controls the body clock, has such a profound impact on how much fat is stored on the body, and how much lean tissue is maintained.»

But the babies of adiponectin - treated mice were about the same weight as those born to lean control mice, the researchers report online today in the Proceedings of the National Academy of Sciences.

Now Catherine Suter at Victor Chang Cardiac Research Institute in Sydney and her colleagues have investigated the longer - term effects of paternal obesity by mating obese male mice with lean females.

To explore that question, a team led by Cornell University biomedical engineer Claudia Fischbach first showed that female mice that were obese, because of genetics or a high - fat diet, had more fibrous mammary fat pads with straighter collagen fibers than those seen in lean mice (see image).

The researchers used electron microscopy and other imaging techniques to view thousands of cells from the liver tissue of lean and obese mice.

Based on the observation that obese mice, rats, and humans all had elevated serum concentrations of a protein called GDF15 compared to lean controls, Yumei Xiong and colleagues set out to develop therapies derived from the molecule.

This is interesting, given that muscle / lean muscle mass ratios of non-skeletal muscle organs from IL - 15Rα — KO mice, such as the heart, spleen, and kidneys, were not significantly different from those of B6129 controls.

Correlation of gene expression occurred across lean and obese mice, defining a common transcriptional response to variations in adiposity.

Our results indicate that the percentage of macrophages in the adipose tissue that surrounds and infiltrates the extensor digitalis longus muscle is increased in obese mice compared with lean mice.

We examined six experimental groups of 20 - week - old C57BL / 6J mice: (a) lean C57BL / 6J female mice, (b) lean C57BL / 6J male mice, (c) moderately obese C57BL / 6J male mice with diet - induced obesity, (d) moderately obese female B6.Cg Ay / + mice, (e) severely obese female B6.V Lepob / ob mice, and (f) severely obese male B6.V Lepob / ob mice.

We estimate that the percentage of macrophages in adipose tissue ranges from under 10 % in lean mice and humans to over 50 % in extremely obese, leptin - deficient mice and nearly 40 % in obese humans.

Adipose tissue within muscle contained significant numbers of F4 / 80 + macrophages, and the percentage of F4 / 80 + cells within this adipose tissue was markedly increased in obese mice compared with lean mice (41 % ± 4 % of macrophages vs. 12 % ± 2 % of macrophages, respectively; P < 0.005, mean ± SD)(Figure 4).

Macrophages in the liver and muscle of lean and obese mice.

Immunohistochemical detection of cells expressing the macrophage - specific antigen F4 / 80 (arrows) in extensor digitalis longus muscles from C57BL / 6J (a and c) Lepob / ob female and (b and d) lean female mice.

This difference may be explained by the reduced levels of normal CST in obese mice compared to the lean control animals.

We calculated the average adipocyte cross-sectional area and the percentage of F4 / 80 - expressing cells in the perigonadal, perirenal, mesenteric, and subcutaneous inguinal adipose tissue depots from Ay / + female, Lepob / ob female, lean male, and diet - induced obese (DIO) male mice.

Results showing C. minuta has an effect of controlling fat gain in the mouse match data that reveal lean people have a greater abundance of C. minuta in their gut than obese people.

The percentage of F4 / 80 - positive macrophages within this adipose tissue was markedly increased in obese compared with lean mice (e, P < 0.005).

In 2005, together with Washington University microbiologist Jeffrey Gordon and others, Knight used the tools to catalog the microbes that inhabit the intestines of lean and obese mice, in hopes of uncovering relationships between microbes and metabolic health.

Treated mice become lean, and develop larger muscles and endurance, suggesting a multitude of therapeutic uses in people.

While IRAB - A produced a decrease in blood glucose in lean mice, the data in DIO mice indicated an exacerbation of insulin resistance; these data were unexpected and suggested the interplay of complex unknown pharmacology.

Lean and diet - induced obese mice were used to characterize single - dose in vivo pharmacological effects of IRAB - A; multiple - dose IRAB - A effects were tested in obese mice.

Both obese humans and mice have significantly elevated soluble Fabp4 / aP2 levels, and injection of recombinant Fabp4 / aP2 into lean wild type mice stimulates hepatic glucose production and gluconeogenesis.

After exercising for six weeks, both obese and lean mice showed a significant reduction in the overall size of fat cells and the overall amount fat in the marrow.

In one study, researchers took microbiome samples from both lean and obese mice and placed them in the gut of neutral mice.

Their procedure involved infecting mice without microbiota with either microbiota of obese or lean mice.

Additionally, fecal transplant of gut microbes from obese mice to GF mice results in greater adiposity in the GF recipients than fecal transplants from lean donors (2).

Actually, the leucine - deprived mice showed no difference in lean mass, from either the control mice or those that were restricted to the same number of (reduced) calories consumed by the leucine - deprived mice.

Pair - fed mice lost only 5 percent of bodyweight, and their lean mass did not change appreciably; leucine deprived mice lost 15 percent of body - weight, and their lean mass was the same as the control mice, and unchanged.There were no strength or endurance challenges, but when one considers that the mice lost 50 percent of abdominal fat, 15 percent of bodyweight, and had no loss of lean mass, that is incredible.

However — and this part is miraculous — when Dr. Panda and his team restricted the time the mice were fed the exact same crappy diet to 12 hours (instead of allowing them to eat whenever they wanted), none of the negative health benefits occurred; the Time - Restricted Fed mice were 70 % leaner, lived longer and were free from diabetes or heart disease.

To explore whether this was a cause of obesity or the effect of it, another research team gave mice the bacteria from sets of twins where one was obese and the other was lean.

This study has examined the effect of alpha - lipoic acid on glucose uptake by cultured L6 muscle cells and different types of skeletal muscles in normal lean (+ / +) and severely insulin - resistant, obese - diabetic (ob / ob) mice.

A game of cat and mouse in the Michigan snow means Mick and her unwelcome cohort must learn to lean on each other — and that closeness leads to an explosive attraction.