Sentences with phrase «of lentiviral vectors»

He has pioneered the development and applications of lentiviral vectors for gene transfer, which have become one of the most widely used tool in biomedical research and, upon recently entering clinical testing, are providing a long sought hope of cure for several currently untreatable and otherwise deadly human diseases.

Read on to learn more about the current (and future) applications of lentiviral vectors!

Cronin J, et al. «Altering the tropism of lentiviral vectors through pseudotyping.»

Cronin, J., Zhang, X.Y., Reiser, J. «Altering the tropism of lentiviral vectors through pseudotyping.»

for applications that require the large genetic capacity of a lentiviral vector but for which transient transgene expression is sufficient.

Clinical benefits of lentiviral vectors have been observed in small trials for other diseases, including the common hematopoietic disorders

The study also examines the use of lentiviral vectors for cell delivery in treating liver diseases, a tool traditionally used in treating blood disorders.

This is the first published report of lentiviral vector mediated TCR therapy that has shown persistence beyond one month, June said.

In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance.

Denning, W., Das, S., Guo, S., Xu, J., Kappes, J.C., Hel, Z. «Optimization of the transductional efficiency of lentiviral vectors: effect of sera and polycations.»

But what's more, the transplanted cells keep producing a foreign protein slipped inside with the help of a lentiviral vector, the kind usually used for gene therapy.

The library consists of a pool of lentiviral vectors with roughly 73 million semi-random, 30 bp DNA barcodes that are integrated into target cells» genomes upon infection.

To sidestep the shortcomings of currently used cancer models, the Salk team harnessed the power of lentiviral vectors to infect nondividing as well as dividing cells and ferry activated oncogenes into a small number of cells in adult, fully immunocompetent mice.

We also demonstrated that this observation was not caused incidentally by a particular vectoring system: using intraductal injection of a lentiviral vector (Bu et al., 2009) to introduce caErbb2 to ductal epithelia, we also observed accelerated tumorigenesis in the parous group relative to the virgin group (Figure 1 — figure supplement 2).

Researchers have also developed integrase - deficient lentiviral vectors for applications that require the large genetic capacity of a lentiviral vector but for which transient transgene expression is sufficient.

Clinical benefits of lentiviral vectors have been observed in small trials for other diseases, including the common hematopoietic disorders sickle cell anemia and beta - thalassemia.