A large - scale genetic study of the links between telomere length and risk for five common cancers finds that long telomeres are associated with an increased
risk of lung adenocarcinoma.
As a result, the incidence
of lung adenocarcinoma in smokers has risen in the last 50 years relative to other lung cancer subtypes.
One major change is the recommendation to test for alterations to the gene ROS1 in all
cases of lung adenocarcinoma, which make up about half of all cases of non-small cell lung cancer.
«This is one of the most comprehensive
studies of lung adenocarcinoma to date,» said co-author Joshua Campbell, a post-doctoral fellow in the Meyerson lab.
In 2011, the Journal for Thoracic Oncology published the «International Association for the Study of Lung Cancer / American Thoracic Society / European Respiratory Society International Multidisciplinary
Classification of Lung Adenocarcinoma,» issued by a multidisciplinary team of lung cancer specialists.
21) Somwar R, Erdjument - Broonage H, Larsson E, Shum D, Lockwood WW, Yang G, Sander C, Ouerfelli O, Tempst PJ, Djaballah H, Varmus H (2011) SOD1 is a target for a small molecule identified in a screen for inhibitors of the
growth of lung adenocarcinoma cell lines.