«Immunotherapy data heralds new era
of lung cancer treatment.»
A blood pressure drug may make a type
of lung cancer treatment more effective, suggests a new study.
«Blood pressure drug may boost effectiveness
of lung cancer treatment.»
Not exact matches
This drug has already staked its claim in the world
of next - gen «checkpoint inhibitor»
cancer treatments by besting rival Bristol - Myers Squibb's competing
treatment Opdivo in advanced non-small cell
lung cancer (NSCLC).
At 55 years old, Carol Cesario's stage IV
lung cancer treatments induced hallucinations
of Jon Bon Jovi, a rock star she's loved since the»80s.
Merck R&D chief Roger Perlmutter said his company believes the Keynote - 024 results «have the potential to change the therapeutic paradigm in first - line
treatment of non-small-cell
lung cancer.»
The biotech specialist said that its updated phase 2 data in a study
of its poziotinib candidate
treatment for non-small cell
lung cancer resulted in a preliminary confirmed objective response rate and potential progression - free survival benefit in patients with the EGFR Exon 20 Mutant form
of the disease.
«What is particularly encouraging is that we are now able to select, based on features in the tumor, approximately a quarter
of advanced
lung cancer patients who can receive immunotherapy as their initial
treatment.
«One
of the toughest challenges
of lung cancer is what to do for patients when the
cancer comes back in an area that's been treated previously with radiation
treatment,» said James J. Urbanic, M.D., lead author
of the studies and a radiation oncologist at Wake Forest Baptist.
Aaron P. Mitchell, M.D.,
of the University
of North Carolina at Chapel Hill School
of Medicine, and coauthors examined FCOIs during 2014 among 125 authors
of the guidelines for the
treatment of breast, colon, prostate and
lung cancer because those are the
cancers with the highest incidence in the U.S.
Approximately one year after successful
treatment with cytotoxic chemotherapy and radiotherapy, patients with advanced Small Cell
Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence
of tumours that are resistant to further chemotherapy.
If hypofractionated radiation with curative intent can reduce the
treatment time for
lung cancer patients by half with no greater toxicity, and with equivalent — if not better — tumor control and survival outcomes, this research could result in a change in the paradigm
of how a large subset
of locally advanced NSCLC patients are treated.»
It's just a very different time now,» he said
of the progress being made in the
treatment of lung cancer.
Pembrolizumab, or pembro, an immunotherapy drug that unmasks
cancer cells and allows the body's own immune system to help destroy tumors, appears to be safe in treating lung cancers, according to a study by Cancer Treatment Centers of America ® (CTCA) at Western Regional Medical Center (Western) in Goodyear, Ar
cancer cells and allows the body's own immune system to help destroy tumors, appears to be safe in treating
lung cancers, according to a study by
Cancer Treatment Centers of America ® (CTCA) at Western Regional Medical Center (Western) in Goodyear, Ar
Cancer Treatment Centers
of America ® (CTCA) at Western Regional Medical Center (Western) in Goodyear, Arizona.
Unfortunately, the
treatment had little effect on the survival
of the terminally ill
lung cancer patients in the first trial.
«There has been a tremendous effort over the past several years to block EGFR as a
treatment for
lung cancer, but this therapy only works in a small subset
of patients.
«Blocking both
of these proteins could be a
treatment that is beneficial for the majority
of lung cancer patients,» said Dr. Habib, Associate Professor
of Neurology and Neurotherapeutics with UT Southwestern's Peter O'Donnell Jr..
«We urgently need new
treatments for
lung cancer patients, and this research suggests we can boost the effectiveness
of an existing drug, rather than switch to another new expensive
treatment.
The trial also recorded fewer cases
of lung cancer in those on the
treatment, consistent with basic research findings hinting that the same inflammatory pathway may initiate or spur tumor growth.
A one - two combo punch using two currently available drugs could be an effective
treatment for the majority
of lung cancers, a study by scientists with UT Southwestern's Simmons
Cancer Center shows.
Compared to a control (left), epalrestat
treatment (right) reduces the number
of metastatic tumors (arrowheads) in the
lungs of mice injected with human basal - like breast
cancer cells.
Called the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) and funded by the drug giant Novartis, the trial also found fewer cases
of lung cancer in those on the
treatment, rekindling basic research findings hinting that the same inflammatory pathway may initiate or spur the growth
of such tumors.
«Although some non-small cell
lung cancer patients have increased benefit
of targeted therapy or immunotherapy instead
of chemotherapy, for some groups
of patients with NSNSCLC, chemotherapy has been the standard
treatment for more than 30 years,» Gandhi notes.
This pre-clinical study from Professor Mazzone and his colleagues reveals a new molecular axis that may offer interesting therapeutic opportunities for the
treatment of pancreatic
cancer, breast
cancer and
lung cancer, among others.
Identification
of a specific genetic mutation in patients with non-small-cell
lung cancer (NSCLC) helps clinicians select the best
treatment option.
Among patients with non-small cell
lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the number
of circulating tumor cells (CTCs) harboring increased copies
of the ALK gene over the first two months
of treatment was associated with increased progression - free survival.
Phase I / II clinical trial results reported at the American Society for Clinical Oncology (ASCO) Annual Meeting 2015 show promising results for investigational drug brigatinib against ALK + non-small cell
lung cancer (NSCLC), with 58
of 78 ALK + patients responding to
treatment, including 50
of 70 patients who had progressed after previous
treatment with crizotinib, the first licensed ALK inhibitor.
Few existing
treatments offer durable survival benefits for patients whose NSCLC has spread past the
lungs, due in part to the aggressive nature
of lung cancer and its propensity to progress, even following
treatment.
Among patients with advanced non-small cell
lung cancer without a mutation
of a certain gene (EGFR), conventional chemotherapy, compared with
treatment using epidermal growth factor receptor tyrosine kinase inhibitors, was associated with improvement in survival without progression
of the
cancer, but not with overall survival, according to a study in the April 9 issue
of JAMA.
Pembrolizumab is set to become a new option for first line
treatment of patients with advanced
lung cancer and high PD - L1 expression, according to the results
of the phase III KEYNOTE - 024 trial presented at the ESMO 2016 Congress in Copenhagen and published in the New England Journal
of Medicine.
Now doctors have investigated the use
of crizotinib in patients with ALK positive
lung cancer who have not yet received any chemotherapy
treatment.
P: We found discodermolide [a drug from Discodermia, a sponge found in the Caribbean, the Bahamas, and the Gulf
of Mexico], and it's gone through phase I clinical trials for
treatment of solid tumors such as ovarian, pancreatic, breast, colon, or
lung cancers.
In the group that received targeted
treatment for ALK - positive
lung cancer, each category
of tumor reduction was associated with corresponding gains in PFS and OS.
«This study demonstrates the value
of testing
lung cancer tissue for an ALK rearrangement, and it underscores the potential
of cancer genomics to target
cancer treatments to each patient,» says the study's senior author, Pasi A. Jänne, MD, PhD, who is the director
of the Lowe Center for Thoracic Oncology
of Dana - Farber.
«First - line immunotherapy
treatment can improve survival for subset
of lung cancer patients: Results
of phase III global clinical trial show that 75 percent
of stage IV
lung cancer patients with both complex tumor mutations and PDL - 1 positive status respond to nivolumab.»
Your special report on the
treatment of lung cancer (30 June, p 6) is very illuminating.
Right now, the tests, which are available from several companies, mostly aid in
treatment decisions for people already diagnosed with a particular form
of cancer, such as prostate or
lung.
Treatments for diabetes, smoking, Alzheimer's disease and
lung cancer are just a few
of the potentially lifesaving cures Scientific American has chosen to highlight in this year's roundup
of drugs you've never heard
of, despite their potentially huge impact on global health.
«We're just beginning to understand the relevance
of airway field cancerization to
lung cancer detection and development
of treatment and prevention strategies,» Kadara said.
The authors found that most
lung cancer patients (regardless
of stage) want physical activity advice directly from a physician at a
cancer center before
cancer treatment and exercise guidance may increase compliance with a dedicated program.
Moving forward, they plan to continue testing derivatives
of HIPP for the
treatment of colon
cancer and also see if their findings extend to breast,
lung, ovarian and prostate
cancers.
A new drug that targets not only common
cancer - causing genetic mutations in patients with non-small cell
lung cancer (NSCLC), but also a form
of the mutation that causes resistance to
treatment, has shown promising results in patients in a phase I / II clinical trial.
Biopsies
of pulmonary lesions are essential for increasing the accuracy
of diagnosis and
treatment for respiratory illnesses such as
lung cancer.
Other factors that increased suicide risk were being older, being widowed, refusing surgical
treatment and having a difficult - to - treat (metastatic) type
of lung cancer.
Clinical trials found that it is safe to regularly infuse brain and
lung cancer patients with 800 — 1000 times the daily recommended amount
of vitamin C as a potential strategy to improve outcomes
of standard
cancer treatments.
«For about 80 percent
of our patients with
lung cancer, we don't have tests like [the one for] ALK to tell us what
treatments will work best,» Shaw says.
This poor performance is sadly typical for
lung cancer treatments: Most are effective for between 3 and 15 percent
of patients.
Susan Galbraith, head
of the oncology innovative medicines unit at AstraZeneca, said: «
Lung cancer is still the leading
cancer killer, and we are working on a number
of potential
treatment options that could provide patients with a better chance
of beating the disease.
The
treatment is promising enough that research teams around the world are developing similar stem cell therapies that can target and eradicate
cancers of the prostate,
lung, breast, skin and other tissues.
«Some had failed multiple lines
of treatment and were very, very sick, with advanced - stage
lung cancer,» Shaw says.