A major challenge facing mass drug administration (MDA) programmes targeting the control and elimination
of lymphatic filariasis or onchocerciasis is the serious adverse - sometimes life threatening - reactions that this treatment can have on people who are also infected with loisasis.
Not exact matches
But the system has seen success in some areas recently, like limiting the spread
of HIV and
lymphatic filariasis.
While medications currently exist to treat
lymphatic filariasis and onchocerciasis, the two main diseases caused by filarial nematodes, the drugs are insufficient to eliminate the diseases by 2020 and researchers project that resistance will arise to some
of the drugs.
On Monday, the 2015 Nobel Prize in Physiology or Medicine went to William Campbell
of Drew University in Madison, New Jersey, and AAAS member Satoshi Ōmura
of Kitasato University in Tokyo, who will share half the prize for discovering the drug avermectin, which has been used to treat river blindness and
lymphatic filariasis as well as other parasitic diseases.
Urbanization and the resulting shrinkage
of green spaces in cities can be considered a boon for mosquitoes that transmit diseases, such as Aedes aegypti (dengue) and Culex quinquefasciatus (
lymphatic filariasis).
Use
of this technology to exclude patients from ivermectin - based treatment at the point
of care in Loa - endemic regions would allow resumption / expansion
of mass drug administration programs for onchocerciasis and
lymphatic filariasis in Central Africa.
Clinical samples from two groups
of individuals from the south Pacific island
of Mauke and from Ecuador — one group infected with filarial worms causing
lymphatic filariasis and a second group infected with intestinal roundworms Ascaris — revealed increased levels
of resistin in the infected individuals compared to those who were uninfected or immune.
Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission
of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research
of a reformulated form
of flubendazole for
lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation
of Vermox (mebendazole) that will facilitate treatment
of intestinal worms in younger children.
Lymphatic filariasis (LF) is caused by a species
of filarial round worms, or nematodes, transmitted by mosquitoes.
Those individuals with high levels
of co-infection are the most likely to experience adverse reactions to ivermectin, the deworming drug used to target
lymphatic filariasis and onchocerciasis.
The Tool can visualize the geographical distribution
of all
of the main preventative chemotherapy (PCT) NTDs: schistosomiasis, soil - transmitted helminths,
lymphatic filariasis, onchocerciasis and blinding trachoma.
GAHI shows the geographical distribution
of neglected tropical diseases transmitted by worms: soil - transmitted helminthiasis, schistosomiasis, and
lymphatic filariasis.
In 1998, Merck expanded the program to include the elimination
of another disease,
lymphatic filariasis.