Sentences with phrase «of lymphoid cells»

Tissue overgrowth (hyperplasia), either of lymphoid cells or macrophages with fibrous tissue (fibrohistiocytic nodules) is also common.

Although we were able to now detect more distinct T and B cell populations in the transplanted immunocompetent MRL and 129SvJ mice, the numbers of lymphoid cells remained far less than would be expected after bone marrow transplantation.

STAT5 activation is required for interleukin -9-dependent growth and transformation of lymphoid cells

Using mice bred to lack some types of lymphoid cells, among other features, researchers were able to show that those mice still had high levels of suPAR and proteinuria, indicating that lymphoid cells were not the perpetrators of kidney disease.

Adult male mice also started off with fewer of the lymphoid cells in the lungs than adult females, the researchers found: Female mice had about 1 1/2 times as many of these immune cells as males.

Not exact matches

Consistent with this idea, microscopic examination of fetal small intestine before birth reveals immature epithelium and sparse lymphoid cells.

But the bottom line is that about two thirds of all T cells reside in the lymphoid tissue of the gut, where the virus spreads after exposure, even before it shows up in blood.

«We could visualize hot spots of infection within lymphoid tissue, which has millions of cells moving dynamically within the tissue,» says Mr. Law.

«The fundamental «killing units» of CD4 T cells in lymphoid tissues are other infected cells, not the free virus,» says co-first author Gilad Doitsh, PhD, a staff research investigator at the Gladstone Institute of Virology and Immunology.

One key cell that is an early initiator of this allergic inflammation is known as a «type 2 innate lymphoid cell» (ILC2).

When injected together with factor VIII into mouse models of haemophilia A, the nanoparticles deliver their payload to cells in the lymphoid tissue that are responsible for initiating immune responses.

During this critical period of interaction, lymphoid cells become «activated» and thereafter can develop into antibody - producing cells independently of native antigen, macrophages, and cell clusters.

«Although it's still early days for this line of research, these findings provoke the hypothesis that MHCII + innate lymphoid cells may be an important pathway to therapeutically target in the treatment of some chronic inflammatory diseases,» suggests Sonnenberg.

Further investigation revealed that the increased susceptibility was due to a reduction in production by the innate lymphoid cells of IL - 22, a protein that plays a key role in the intestinal immune response.

New research shows that all - trans - retinoic acid (atRA), the active form of vitamin A, regulates immune system responses in the mouse intestine by controlling expression of the protein HIC1 in cells known as innate lymphoid cells.

The researchers deleted the HIC1 gene in certain innate lymphoid cells in the mouse intestine and found that this increased the susceptibility of the mice to infection with the bacterium Citrobacter rodentium.

Gregory F. Sonnenberg, PhD, research associate in the Department of Medicine, Gastroenterology Division, and the Institute for Immunology at the Perelman School of Medicine, University of Pennsylvania, with postdoctoral researcher Matthew Hepworth, PhD, report in Nature that innate lymphoid cells (ILCs) directly limit the response by inflammatory T cells to commensal bacteria in the gut of mice.

Innate lymphoid cells (ILCs) are immune cells that regulate early immune responses against viruses, bacteria and parasites through the release of soluble factors.

Even at this stage, measuring the number of innate lymphoid cells in the blood makes it possible to provide a prognosis of the effects of treatment.

Researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have discovered that innate lymphoid cells, early responders of the immune system, are primed at the DNA level for rapid action.

These lymphoid cells are thus an important target for the treatment of infection and chronic inflammation.

Innate lymphoid cells in the intestine of healthy mice.

A research group from the Department of Biomedicine at the University and the University Children's Hospital of Basel now discovered that innate lymphoid cells become activated and induce specific T and B cell responses during inflammation.

«These findings will make it possible to significantly improve the quality of treatment of rheumatoid arthritis in future with the help of innate lymphoid cells,» says Dr Ramming.

Previous research has shown that atRA, produced from dietary vitamin A by some intestinal cells, helps maintain this balance in mice by regulating the activity of innate lymphoid cells.

According to Simon Rauber, an immunologist in Erlangen and primary author of the study, a previously inadequately studied cell population of the immune system called innate lymphoid cells plays a major role in the resolution of inflammations.

Through the use of powerful genomic techniques, researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have found that the development of immune cells, called innate lymphoid cells (ILCs), gradually prepares these cells for rapid response to infection.

This temporary colonization of E.coli in the mother affected the immune system of her offspring; after birth, the offspring harbored more innate lymphoid and mononuclear cells in their intestines compared to mice born to microbe - free pregnant mothers.

The research team, a collaborative partnership between the groups of Professor Gabrielle Belz of Melbourne's Walter and Eliza Hall Institute, and Professor Eric Vivier at the Centre d'Immunologie de Marseille - Luminy, France, found that innate lymphoid cells (ILCs) are crucial for protecting against bacterial infection in people with compromised immune systems.

In humans, Newcomb and her colleagues measured the number of group 2 innate lymphoid cells circulating in the blood of adults with moderate to severe asthma.

When hypoxia occurs, the activity of CD45 — a protein found in myeloid and lymphoid cells — increases.

Early discoveries led researchers to home in on the hematopoietic system, the organs that produce the two kinds of blood cells, lymphoid and myeloid cells.

Immunologist Sharon Evans of Roswell Park Cancer Institute in Buffalo, New York, and coworkers are studying how fever affects the movement of white blood cells, or lymphocytes, from the blood into lymphoid tissue, where they learn to recognize and fight pathogens.

The phenotype of NP cells generated ex vivo (Figure S8) closely resembles that of central memory CD4 + T cells found in vivo, which persist for years in secondary lymphoid organs and can differentiate into effector memory CD4 + T cells [45].

Induction of rotavirus - specific memory B cells in gut - associated lymphoid tissue after intramuscular immunization.

Distribution of rotavirus - specific memory B cells in gut - associated lymphoid tissue after primary immunization.

Lyt phenotype of T cells in lymphoid tissues and blocking of tumor rejection.

The frequency of CD39highCD8 + T cells increased with tumor growth but was absent in lymphoid organs.

Masters et al. discuss the often overlooked contribution of the stromal microenvironment as an extrinsic factor to immunosenescence and inflammation.12 Accumulation of senescent stromal cells which demonstrate the senescent associated secretory phenotype (SAPS), may alter tissue structure and function, and increase local inflammation.13 The impact of altered lymphoid stromal microenvironment may be widespread and include altered haematopoiesis, reduced lymphatic flow and disrupted secondary lymphoid organisation, which consequently will alter antigen transportation and presentation to T cells.12

Development and Functions of CD4 T Helper (Th) and Innate Lymphoid Cell (ILC) Subsets Jinfang ZhuNational Institutes of Health, Bethesda, USA 10 April 201804:15 pm Host: Max Löhning, DRFZ, Berlin Location: Max Planck Institute for Infection Biology, Seminar room 1/2 - Campus Charité Mitte

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

Research Focus: My research focuses on the role of the herpesvirus entry mediator (HVEM) of by Innate Lymphoid Cells (ILC) and intraepithelial lymphocytes (IEL) in the Intestine.

Diagnosis of BPDCN was confirmed by the positivity of the cells for CD4 and CD56, along with other markers that are more restricted to plasmacytoid dendritic cells (such as CD123), and the negativity of the cells for lymphoid, NK and myeloid lineage - associated antigens.

Schallenberg S, Tsai PY, Riewaldt J, Kretschmer K. Identification of an immediate Foxp3 − precursor population to Foxp3 + regulatory T cells in peripheral lymphoid organs of non-manipulated mice.

Canadian Society for Immunology (CSI) Symposium Innate Lymphoid Cells and Inflammatory Disease Monday, May 7, 3:45 PM — 5:45 PM, Room 10AB Chairs: Kelly McNagny, Univ. of British Columbia Arthur Mortha, Univ. of Toronto

[31] Recent studies show that the vaginal mucosa can support T - cell induction in the absence of MALT or secondary lymphoid tissues, suggesting that the type II vaginal mucosa can itself act as an inductive site for the generation of primary CD8 + T - cell immune responses.

N.L.K. Galloway et al., «Cell - to - cell transmission of HIV - 1 is required to trigger pyroptotic death of lymphoid - tissue - derived CD4 T cells,» Cell Reports, 12:1555 - 63, 2Cell - to - cell transmission of HIV - 1 is required to trigger pyroptotic death of lymphoid - tissue - derived CD4 T cells,» Cell Reports, 12:1555 - 63, 2cell transmission of HIV - 1 is required to trigger pyroptotic death of lymphoid - tissue - derived CD4 T cells,» Cell Reports, 12:1555 - 63, 2Cell Reports, 12:1555 - 63, 2015.

Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector.

T cells exert their actions in two ways, either through direct cell - cell contact which involves transmembrane proteins present on both the T cell and interacting cell, or by the secretion of soluble proteins termed cytokines which have receptors on many lymphoid and some non-lymphoid cell types.

Professor Kyurkchiev's group is currently developing a project on the controlled differentiation of human induced pluripotent stem cells into hematopoietic stem cells and lymphoid cells.