Sentences with phrase «of lysosomal enzymes»

The mucopolysaccharides, which aid in bone formation, as well as that of the skin, cornea and cartilage, don't perform their function properly because of a lack of lysosomal enzymes.

The disease causes an accumulation of mucopolysaccharides, or glycosaminoglycans (GAGs) due to the impaired functioning of lysosomal enzymes that break down GAGs which help build bones, cartilage, skin, tendons, corneas and the fluid responsible for lubricating joints.

The ensuing decrease in pH and / or the presence of the lysosomal enzymes such as cathepsin B lead to premature activation of trypsinogen.

LTB4 increases edema and chemotaxis, induces release of lysosomal enzymes, increases reactive oxygen species, and enhances production of the cytokines TNF - α, IL - 1, and IL - 6.»

Comparative binding, endocytosis, and biodistribution of antibodies and antibody - coated carriers for targeted delivery of lysosomal enzymes to ICAM - 1 versus transferrin receptor.

Not exact matches

Specifically, the current study demonstrated that an accumulation of oxidized dopamine depressed the activity of lysosomal glucocerebrosidase (GCase), an enzyme implicated in PD.

Targeting, Endocytosis, and Lysosomal Delivery of Active Enzymes to Model Human Neurons by ICAM -1-Targeted Nanocarriers.

So the idea would be to identify the enzymes these organisms use to digest lysosomal wastes, modify them a bit to help them work in the slightly different environment of the human lysosome, and then deliver them to where they need to go in our cells.

If such enzymes didn't exist, then the planet would be ankle - deep in the undegraded lysosomal wastes left over from the cells of 600 million years of animal life on this planet.

Our lead candidate, LYS - GM101, has been designed to replace this defective gene in the cells of GM1 patients, in order to allow for production of the functional lysosomal acid beta - galactosidase (bgal) enzyme.

Furthermore, ApoE4 caused a disruption of lysosomal integrity and a shift in the localization of Cathepsin D, an enzyme known to degrade Trx1.

Lysis of these A beta 42 - burdened neurones apparently resulted in a local, radial dispersion of their cytoplasmic contents, including A beta 42 and lysosomal enzymes, into the surrounding extracellular space.

Quantitative Differences in the Urinary Proteome of Siblings Discordant for Type 1 Diabetes Include Lysosomal Enzymes.

Cutting Edge: Induction of the Antigen - Processing Enzyme IFN --LCB- gamma -RCB-- Inducible Lysosomal Thiol Reductase in Melanoma Cells Is STAT1 - Dependent but CIITA - Independent

However, data from other animal models demonstrate diminished lysosomal enzyme activity during extended periods of energy restriction (39).

Vacuole formation is thought to be a consequence of the uncoupling of exocytosis of zymogens and abnormal intracellular traffi cking of digestive and lysosomal enzymes.

Biochemical studies have shown that these vacuoles are the product of co-localization of zymogens of digestive enzymes and lysosomal enzymes, which are normally strictly segregated.

In the lipid storage form of lysosomal storage disease I mentioned that dogs and cats can be born with decreased or missing lysosome enzymes that allows them to process fatty substances (lipids).

For example, the conversion of trypsinogen (inactive) to its active form, trypsin, can be triggered by enterokinase, bile, lysosomal enzymes or other stimuli.