Sentences with phrase «of macrophage activation»

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Soluble CD14 levels were inversely correlated with measures of bone mineral content and density, suggesting macrophage activation as a possible mechanism for such bone loss.

«We hope that interventions to decrease macrophage activation early in HIV infection will decrease associated bone loss, which has become a major adverse side effect of HIV infection and its treatment,» Aldrovandi said.

«HIV - infected young males have higher rates of bone loss than females: Study suggests macrophage activation as possible reason for differential bone loss in adolescent males.»

«These findings question a long - held paradigm that myelin - specific T cells initiate inflammation in the brain through activation of microglia and brain macrophages,» says Scott Zamvil, MD, PhD, a professor of neurology at the University of California, San Francisco and co-author on the paper.

What Litvak found is that the MeCP2 gene is responsible for establishing a threshold for the activation of macrophages in the presence of stimuli and stressors such as hypoxia, corticosteroids and inflammation.

Researchers from Aarhus University Hospital and Aarhus University have studied how to measure activation of macrophages.

Through studies conducted in mice, Oliver M. Steinmetz, MD (University Hospital Hamburg Eppendorf, in Germany) and his colleagues have shown that the messenger protein IL - 6, which is rapidly produced at high levels during an acute inflammatory form of kidney disease, potently dampens activation of tissue - destructive immune cells called macrophages.

A balance between the activation of the inflammatory macrophages and suppression of the anti-inflammatory macrophages in the kidney may play a pivotal role in kidney stone formation.

According to Faron, the Clevegen antibody is well differentiated from competing products by its ability to specifically target TAMs of the M2 variety (which facilitate tumor growth) while sparing M1 macrophages that support antitumor immune activation and desirable immunity in general.

Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte - macrophage colony - stimulating factor - secreting breast tumor vaccine: a chemotherapy dose - ranging study of safety and immune activation.

Pinellia ternata lectin exerts a pro-inflammatory effect on macrophages by inducing the release of pro-inflammatory cytokines, the activation of the nuclear factor -?

1,25 - dihydroxyvitamin D3 protects against macrophage - induced activation of NF?B and MAPK signalling and chemokine release in human adipocytes.

Activation of a TGF --LCB- beta -RCB-- Specific Multistep Gene Expression Program in Mature Macrophages Requires Glucocorticoid - Mediated Surface Expression of TGF --LCB- beta -RCB- Receptor II.

Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment imacrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment iMacrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?

The mechanism of action is based on the activation of macrophages to defend against tumors by direct tumor cytotoxicity and consequently they secrete cytokines which recruit secondary immune cells, presenting antigen to T cells [5 - 7].

Activation of cytosolic phospholipase A2α in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2.

The supernatant of apoptotic cells causes transcriptional activation of hypoxia - inducible factor — 1α in macrophages via sphingosine -1-phosphate and transforming growth factor - β.

It is a potent cytokine in the development, further activation and trafficking of macrophages, DCs and other innate cells.

Without Nr4a1 to put a damper on production, monocytes and macrophages increase secretion of norepinephrine, which in turn leads to the activation of macrophages, thereby amplifying neuroinflammation and causing a massive influx of T cells into the central nervous system.

Heart regeneration in the salamander relies on macrophage - mediated control of fibroblast activation and the extracellular landscape, npj Regenerative Medicine (2017).

The protection is a result of systemic macrophage activation triggered by - interferon.

Scientists aren't exactly sure, but in line with the study on NF - KappaB, they believe that glycine acts directly on inflammatory cells such as macrophages to suppress activation of transcription factors and the formation of inflammatory cytokines in the first place.

Similar to a pathogenic response to an invading bacterium, excess nutrients found in the obese adipose microenvironment can lead to the pro-inflammatory activation and phenotypic switch (from M2 resident to M1 inflammatory macrophage) of macrophage [24].

Ghosh SS, Bie J, Wang J, Ghosh S. Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet - induced atherosclerosis and glucose intolerance in LDLR - / - mice — role of intestinal permeability and macrophage activation.

Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin - 3 expression in the colon, causing the laxative effect of rhubarb extract.

Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet - induced atherosclerosis and glucose intolerance in LDLR - / - mice — role of intestinal permeability and macrophage activation.

Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA - induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice.

If you like technical explanations, echinacea can increase macrophage activation — by increasing production of interferon gamma.

It is also characterized by a cellular reaction focused on the use of neutrophils and macrophages to «clean up» the site through debridement, phagocytosis, matrix synthesis, and cell recruitment and activation.