If the detection of a major gene were caused by for example environmental factors, shuffling the data would not affect the estimate
of the major gene variance.
In the German Shepherd, the Golden Retriever, and the Labrador Retriever, estimates
of the major gene variance for ED from the shuffled data sets were, at least in one data set, similar to the estimates obtained from the original data.
Estimates
of major gene variance were high in both HD and ED in all breeds studied.
Not exact matches
Estimates
of the same magnitude for ED
major gene variance were obtained from both the original and shuffled data sets in the three breeds, excluding the Rottweiler.
The estimates
of the
variance components suggest that the mode
of inheritance
of hip dysplasia is quantitative, with a
major gene affecting the trait jointly with numerous minor
genes.
Estimated nonparametric marginal densities for polygenic (σ2u) and
major gene (σ2w)
variance for elbow dysplasia (ED) in the Golden Retriever, as an example
of all breeds.
Estimated nonparametric marginal densities for polygenic (σ2u) and
major gene (σ2w)
variance for hip dysplasia (HD) in the German Shepherd, as an example
of all breeds.
If a
major gene variance was detected from an analysis
of a shuffled data set, the hypothesis
of no
major gene (H0) was accepted.