«These findings serve as a critical baseline for tracking the emergence and spread of artemisinin resistance in P. falciparum parasites in sub-Saharan Africa,» says Prof Abdoulaye Djimdé
of the Malaria Research and Training Center, University of Science Techniques and Technologies of Bamako, Mali, who is leading the PDNA.
For many members of the PDNA, this home - grown initiative marks a step towards leadership
of malaria research activities within their communities.
Tu Youyou has been at the forefront
of malaria research for nearly 50 years, and work under her direction has resulted in lifesaving medication for millions.
On April 25, we'll be co-hosting a Twitter chat to discuss the state
of malaria research, recent advancements and what still needs to be done to end it.
As the research manager I have strategic oversight and delegated responsibility for the operational management
of the Malaria research programme.
«Understanding how and why mosquitoes are genetically different from each other is fundamental to many areas
of malaria research» says Dominic Kwiatkowski, one of the project's founders and chair of the Ag1000G data analysis group.
According to Neena Valecha of the National Institute
of Malaria Research in Delhi, India, who led the trial, arterolane may be available by next year.
The researchers agree these discoveries are exciting for the future
of malaria research.
says entomologist Vinod Prakash Sharma, director
of the Malaria Research Center in New Delhi.
But Tsiri Agbenyega, head
of the Malaria Research Unit at Komfo Anokye Hospital in Kumasi, Ghana and chairman of the RTS, S Clinical Trials Partnership Committee, remains optimistic.
Not exact matches
Already we see hints
of that: in the efforts
of the Bill and Melinda Gates Foundation to eliminate
malaria; in Mark Zuckerberg's efforts to improve schools; in Sean Parker, the founder Napster, pledging $ 600 million for
research into cancer and
malaria, among other causes.
Until recently he was a founding member and VP
of J.P. Morgan Sustainable Finance where he helped develop innovative investment structures such as GHIF (the world's first VC fund for HIV &
Malaria Research), Dementia Discovery Fund (a first - of - its kind collaborative effort to accelerate fundamental research in Dementia) and NatureVest, an investment fund focused on nature protection co-developed with The Nature Cons
Research), Dementia Discovery Fund (a first -
of - its kind collaborative effort to accelerate fundamental
research in Dementia) and NatureVest, an investment fund focused on nature protection co-developed with The Nature Cons
research in Dementia) and NatureVest, an investment fund focused on nature protection co-developed with The Nature Conservancy.
The Niger Delta Development Commission (NDDC) has donated N50 million to fund NDDC's Professorial Chair on
Malaria Elimination and Phytomedicine
Research programme at the University
of Port Harcourt...
A publicly owned drug
research and production utility, operating at cost for public benefit instead
of private profit, would use high revenues from drugs that are taken daily or frequently in order to subsidize
research and production
of low - revenue drugs like vaccines for Ebola,
malaria, and other infectious diseases that are used once.
Conducting her dissertation
research in the highlands
of western Kenya on factors affecting contraction
of malaria gave Kacey Ernst insight into why spending time with a community is critical to improving public health.
Eran Bendavid
of Stanford University, US, discussing the
research in an accompanying Perspective, says: «Averting deaths
of young children from
malaria or vaccine - preventable diseases such as polio or measles promotes more stable and prosperous societies.
«This app has the potential to help in the fight against HIV, tuberculosis and
malaria in the developing world, bringing the concept
of mobile healthcare to reality,» said Ali Yetisen, a PhD student in the Department
of Chemical Engineering & Biotechnology, who led the
research.
Welcome to feeding time at Mbita Point, a
malaria research station on the shores
of Lake Victoria, Kenya — one
of the most
malaria - infested places on Earth.
Malaria was already widespread on Sardinia by the Roman period, long before the Middle Ages, as indicated by
research at the Institute
of Evolutionary Medicine
of the University
of Zurich with the help
of a Roman who died 2,000 years ago.
But when the massive rollout
of insecticide - treated bed nets began in Africa in the early 2000s — more than a billion have been distributed — little thought was given to resistance, says Maureen Coetzee, director
of the Wits
Research Institute for
Malaria at the University
of the Witwatersrand in Johannesburg, South Africa.
To make James»
malaria - fighting
research a reality, millions
of mosquitoes would need to be bred in a lab and released into the wild at key intervals.
Preliminary results
of the study were presented at a World Health Organization (WHO) evidence review group meeting, while UNITAID has issued a call for further
research into the use
of endectocide class drugs,
of which ivermectin is currently the only one registered for human use, as new vector control tools in the fight against
malaria and other mosquito borne disease.
Analysing a patient's immune response could be key to quickly and accurately diagnosing
malaria, according to research presented on World Malaria Day at the 27th European Congress of Clinical Microbiology and Infectious Diseases (E
malaria, according to
research presented on World
Malaria Day at the 27th European Congress of Clinical Microbiology and Infectious Diseases (E
Malaria Day at the 27th European Congress
of Clinical Microbiology and Infectious Diseases (ECCMID).
«We are
researching the evolution
of today's diseases such as
malaria to explain why the human body becomes sick at all and how adaptations occur.»
Searching for alternatives, Namita and Avadhesha Surolia,
of the Jawaharlal Nehru Centre for Advanced Scientific
Research in Jakkur, India, infected mice with the
malaria parasite and then injected them with triclosan.
Research educator Tim Riedel works with a student in the University
of Texas at Austin's Freshman
Research Initiative on developing a diagnostic tool for
malaria, Zika virus and more.
«Artemisinin - based compounds have really been the key to success in pushing back
malaria in recent years,» says Timothy Anderson,
of the Texas Biomedical
Research Institute and a co-author on both new studies.
Dr Sian Clarke from the London School
of Hygiene & Tropical Medicine, also a principal investigator in the
research, said: «This study shows that rapid diagnostic tests can improve the use
of artemisinin - based combination therapies — the most effective treatment for
malaria — in drug shops, but it's not without its challenges.
We're heading to the remote village
of Veal Roulem, which means «rainy field» in Khmer, one
of several sites where a team from the Mahidol Oxford Tropical Medicine
Research Unit in Bangkok is wrapping up a pilot study
of a radical approach to eliminating
malaria.
As part
of their
research on
malaria, the scientists had been collecting mosquitoes in a southeastern village called Bandafassi, where they were often bitten.
Experimental
research on drugs, immunology, and the development
of malaria is typically done on related Plasmodium species that infect rodents, including laboratory - reared mice.
The
research was conducted by MalariaGEN, an international network
of scientists and clinicians spread across Africa, Asia and other
malaria - endemic regions
of the world, largely funded by the Wellcome Trust.
Tom Scott
of the Mosquito
Research Laboratory at the University
of California, Davis, says the work represents «cutting edge science» and provides «previously unattainable insights into long distance movement
of malaria parasites».
«Both
malaria and Helicosporidium started out as alga and ended up as intracellular parasites preying on animals, but they have done it in very different ways,» says Keeling, director
of the Centre for Microbial Diversity and Evolution at UBC and a Senior Fellow
of Canadian Institute for Advanced
Research.
Malariacontrol.net What it is: A part
of Africa@Home, malariacontrol.net works with population models to determine the best strategy to control
malaria — from
researching vaccines to deploying mosquito nets.
But the letter — which triggered media stories warning
of a «superbug» on the loose — and White's warning irked many in the famously contentious
malaria research community, where personal animosities and longstanding grudges run deep.
Previous
research had shown that DNA from host animals, and from pathogens such as
malaria, is preserved in the blood meals
of flies.
Support was provided by the National Institute
of Allergy and Infectious Diseases, the Bloomberg Philanthropies, CNRS, Inserm, the University
of Strasbourg, Agence Nationale de la Recherche, and the Johns Hopkins
Malaria Research Institute.
The
research was conducted by the University
of Cape Town (UCT)'s Drug Discovery and Development Centre, H3D, and Medicines for
Malaria Venture (MMV), in collaboration with a team
of international researchers.
«The ability
of MMV048 to block all life cycle stages
of the
malaria parasite, offer protection against infection as well as potentially block transmission
of the parasite from person to person suggests that this compound could contribute to the eradication
of malaria, a disease that claims the lives
of several hundred thousand people every year,» said Professor Chibale, Founder and Director
of H3D, founding Director
of the South African Medical
Research Council (SAMRC) Drug Discovery
Research Unit at UCT, and senior author
of the paper.
You reported
research online showing how the mosquito avoids infection by the
malaria parasite as it passes through its body (11 December 2012, newscientist.com), with talk
of bioengineering its immune system to prevent transmission altogether.
They then teamed up with another
research group to create a gene drive that, unleashed in a lab population
of mosquitoes, spread genes that prevent the insects from harboring
malaria parasites.
Deleting a single gene from mosquitoes can make them highly resistant to the
malaria parasite and thus much less likely to transmit the parasite to humans, according to a new paper from scientists at Johns Hopkins Bloomberg School of Public Health's Malaria Research Ins
malaria parasite and thus much less likely to transmit the parasite to humans, according to a new paper from scientists at Johns Hopkins Bloomberg School
of Public Health's
Malaria Research Ins
Malaria Research Institute.
«Our
research has demonstrated unequivocally that the AP2 - G transcription - factor protein is essential for flipping the switch that initiates the transformation
of malaria parasites in the blood from the asexual stage to the critical sexual stage
of their life cycle,» Llinás said.
Scientists at the Center for Infectious Disease
Research recently uncovered a critical piece in the puzzle
of how
malaria parasites infect their host.
In their paper entitled, «
Malaria in pregnancy alters L - arginine bioavailability and placental vascular development,» Science Translational Medicine, 7 March 2018, Toronto General Research Institute (TGRI) and University of Toronto researchers report that Malawian women with malaria in pregnancy had altered levels of L - arginine which were associated with poor birth ou
Malaria in pregnancy alters L - arginine bioavailability and placental vascular development,» Science Translational Medicine, 7 March 2018, Toronto General
Research Institute (TGRI) and University
of Toronto researchers report that Malawian women with
malaria in pregnancy had altered levels of L - arginine which were associated with poor birth ou
malaria in pregnancy had altered levels
of L - arginine which were associated with poor birth outcomes.
For the trial, Professor Peter Kremsner and Dr. Benjamin Mordmüller
of the Institute
of Tropical Medicine and the German Center for Infection
Research (DZIF) used
malaria parasites provided by Sanaria.
Since then the fund has been quietly accepting proposals for such work and today it rolled out its first large installment
of cash, with more than half
of the funding going toward shoring up
malaria drug
research.
With the continuing rise
of resistance the
research, published in the journal Genome Biology, is key as scientists say that this knowledge could help improve
malaria control strategies.
«If you can replace a natural population
of dengue - transmitting mosquitoes with genetically modified ones that are resistant to virus, you can stop disease transmission,» says study leader George Dimopoulos, PhD, a professor in the Department
of Molecular Microbiology and Immunology and a member
of the Johns Hopkins
Malaria Research Institute.