To determine whether expression of PD - L1 in nephrectomy specimens can be used as a surrogate for expression in the sites of metastases (and vice versa), we examined the correlation
of marker expression (mean AQUA scores for all four cores) between the matched specimens using the Pearson correlation test.
This allowed us to directly compare the patterns
of marker expression in normal and induced retina, and identify cell classes on the basis of their distinctive morphology and location within the eye.
Not exact matches
Prior update Nov 19, 2016 added Sonnenburg links (elimination
of microbiota - accessible carbohydrates (MACs) from the diet results in thinner mucus, increased proximity
of microbes to the epithelium, and heightened
expression of inflammatory
markers.)
Art therapy uses materials such as paint, oil pastels,
markers, clay or crayons as a means
of self -
expression.
These epigenetic switches and
markers in turn help switch on or off the
expression of particular genes.
Prasher and Chalfie were awarded a patent for the use
of GFP as a
marker of gene
expression; in total, it earned Prasher just a few hundred thousand dollars in royalties over 15 years.
At a 0.2 - millimolar sucralose dose similar to the concentration found in the blood
of people with high consumption
of low - calorie sweeteners — equal to four cans
of diet soda per day — the researchers said they observed increased
expression of genes that are
markers of fat production and inflammation.
One
of their goals at the conference was to pinpoint specific
markers of these
expressions, and then use them to identify the emergence
of humans within the paleoanthropological record.
Their presentation is entitled «High
expression of AF1q is an adverse prognostic factor and a prediction
marker of extramedullary disease in multiple myeloma.»
But in the 1 September issue
of the Journal
of Clinical Investigation, cardiologist Michael Parmacek and his colleagues at the University
of Chicago describe how they deleted two genes from the common cold virus to make it unable to cause any sniffling or fever, then replaced them with a
marker gene that turns out an easily detected protein and the SM22 promoter, which turns on
expression of genes in smooth muscle cells that surround arteries.
The results showed that, when applied, a long - term inhibition
of Rho - kinase signaling increased the
expressions of chondrocyte - specific genes and differentiation
markers in human chondrosarcoma 2/8 cells.
The figure in question is supposed to show patterns
of expression for a range
of ES cell
markers in the 11 cell lines.
New
markers suggested include total mass
of hemoglobin, altered
expression of genes related to red blood cell metabolism, ironomics, storage lesions, and the presence
of plasticizers from blood bags in athlete urine samples.
Researchers from BUSM and the University
of Cyprus compared the
markers on the surface
of the cancer cells to gene
expression profile
of breast tumors deposited by researchers in international public databases and found that a molecule named IL13RA2 (IL13R alpha2) was abundant in metastatic or late - stage BLBC.
In the last 15 years, researchers worldwide have generated a large amount
of information about the epigenome: proteins, factors and epigenetic
markers which, when bound to DNA, regulate gene
expression.
They found that ONC201 alters the gene
expression of cancer stem cell
markers and signaling pathways prior to killing the tumor cells, providing pharmacodynamic biomarkers
of response.
The use
of cell surface
markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA
expression is a powerful new way enabling the study
of small cell niches in nongenetically modified animal models and human tissue.
Examination
of gene
expression in patients with non-small cell lung cancer (NSCLC) showed the area adjacent to tumors is rich with cancer
markers.
This observation is further supported by the fact that studying alterations in the
expression of genes also made it possible to identify persons whose levels
of interleukin 6, an inflammation
marker, were reduced as their serum vitamin D levels increased.
Our current work is aimed at recruiting sufficiently large samples
of females to begin work to discover possible gene
expression markers for them.»
Additionally, the researchers said they found evidence that preconception alcohol exposure increased the
expression of some inflammatory
markers in pancreatic tissue.
F3 can detect the
expression of a protein called nucleolin, which is a
marker on the surface
of tumor cells.
Lin and Artandi wondered whether they could use telomerase
expression as a
marker to identify the subset
of cells responsible for regenerating the liver during normal turnover.
Expanding from their previous studies with mice, the researchers first established that under specific conditions, culturing human embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location
of the cerebellum — within three weeks, and the
expression of markers for the cerebellar plate neuroepithelium — the part
of the developing nervous system specific for the cerebellum — within five.
The accumulation
of adipose tissue macrophages in direct proportion to adipocyte size and body mass may explain the coordinated increase in
expression of genes encoding macrophage
markers observed in our microarray
expression data.
By contrast, the R206H ACVR1 mutant only slightly enhances the
expression of initial and early chondrogenesis
markers (collagen type II and aggrecan), consistent with a milder stimulatory effect
of the FOP ACVR1 mutation on chondrocyte differentiation.
Among the three isolated cell populations, the relative gene
expression of macrophage
markers was highest among the F4 / 80 + cells.
Not only were levels
of metabolic compounds different, but the
expression of certain genes involved in metabolism was turned up, and the epigenome
of the cells — molecular
markers on DNA that change gene
expression on a broader scale — was altered.
Kinetics study on
markers of the immune system by gene
expression profiling
of an in vivo heated tumor.
(G — L) In situ hybridization
of wild - type embryos injected with wild - type (G — I) or mutant ACVR1 (J — L) to detect ventral
markers eve1 (G, n = 12/12; J, n = 10/13; onset
of gastrulation) and gata2 (H, n = 14/14; K, n = 15/19; mid-gastrulation) or dorsal
marker foxb1.2 (I, n = 12/12; L, n = 6/13, 7/13 showed no
expression; mid-gastrulation).
Quantitative RT - PCR was used to measure the relative
expression of macrophage
markers (Emr1, Csf1r, Cd68) and an adipocyte - specific gene (Acrp30).
The key experiments included for replication were selected because they examine the induction
of POSTN
expression in the pulmonary stromal fibroblasts and test the role
of POSTN in primary tumor formation and metastatic efficiency, which are relevant as the role
of POSTN as a possible prognostic
marker and target for anticancer therapies is explored (Xu et al., 2012; Nuzzo et al., 2014).
Overexpression
of wild - type ACVR1 in chick micromass cultures resulted in
expression levels
of marker genes that are comparable to those
of the empty viral vector, while cells overexpressing R206H ACVR1 showed upregulation
of collagen type II and aggrecan.
A short - term inhibition
of Rho - kinase failed to induce extracellular matrix production in fibroblasts or in HCS - 2 / 8 cells, while its long - term exposure increased the
expressions of chondrocyte - specific genes and differentiation
markers, and also promoted the synthesis
of sulfated glycosaminoglycans by chondrocytic cells.
In line with our in vitro data, Pkn1 — / — mice showed AKT hyperactivation, elevated NeuroD2 levels, and reduced
expression of PF - PC synaptic
markers during stages
of PF maturation in vivo.
Remarkably, the relative
expression levels
of all
marker genes were only slightly decreased when R206H ACVR1 and Q207D caACVR1 cultures were cotransfected with Noggin, whereas cells expressing the wild - type ACVR1 or empty viral vector showed clear downregulation
of all analyzed
marker genes for chondrogenesis.
While
expression levels
of all
marker genes remained almost unchanged in wild - type ACVR1 cultures compared with the empty viral vector, the
expression profile induced by caACVR1 Q207D displayed evidence
of advanced chondrogenic differentiation as shown by decreased levels
of the early differentiation stage
marker collagen type II together with enhanced
expression of the later - stage
markers Ihh and collagen type X. Indian hedgehog has been shown previously to be induced by BMP signaling transmitted via the ACVR1 receptor (9).
We will develop mathematical models to predict the pathways
of differentiation from naive to memory and effector T - cell subsets based on the characterisation
of surface
marker expression, transcription factors and cytokines production at early and late time points after immunisation.
g (acceleration due to gravity) G (gravitational constant) G star G1.9 +0.3 gabbro Gabor, Dennis (1900 — 1979) Gabriel's Horn Gacrux (Gamma Crucis) gadolinium Gagarin, Yuri Alexeyevich (1934 — 1968) Gagarin Cosmonaut Training Center GAIA Gaia Hypothesis galactic anticenter galactic bulge galactic center Galactic Club galactic coordinates galactic disk galactic empire galactic equator galactic habitable zone galactic halo galactic magnetic field galactic noise galactic plane galactic rotation galactose Galatea GALAXIES galaxy galaxy cannibalism galaxy classification galaxy formation galaxy interaction galaxy merger Galaxy, The Galaxy satellite series Gale Crater Galen (c. AD 129 — c. 216) galena GALEX (Galaxy Evolution Explorer) Galilean satellites Galilean telescope Galileo (Galilei, Galileo)(1564 — 1642) Galileo (spacecraft) Galileo Europa Mission (GEM) Galileo satellite navigation system gall gall bladder Galle, Johann Gottfried (1812 — 1910) gallic acid gallium gallon gallstone Galois, Évariste (1811 — 1832) Galois theory Galton, Francis (1822 — 1911) Galvani, Luigi (1737 — 1798) galvanizing galvanometer game game theory GAMES AND PUZZLES gamete gametophyte Gamma (Soviet orbiting telescope) Gamma Cassiopeiae Gamma Cassiopeiae star gamma function gamma globulin gamma rays Gamma Velorum gamma - ray burst gamma - ray satellites Gamow, George (1904 — 1968) ganglion gangrene Ganswindt, Hermann (1856 — 1934) Ganymede «garbage theory»,
of the origin
of life Gardner, Martin (1914 — 2010) Garneau, Marc (1949 ---RRB- garnet Garnet Star (Mu Cephei) Garnet Star Nebula (IC 1396) garnierite Garriott, Owen K. (1930 ---RRB- Garuda gas gas chromatography gas constant gas giant gas laws gas - bounded nebula gaseous nebula gaseous propellant gaseous - propellant rocket engine gasoline Gaspra (minor planet 951) Gassendi, Pierre (1592 — 1655) gastric juice gastrin gastrocnemius gastroenteritis gastrointestinal tract gastropod gastrulation Gatewood, George D. (1940 ---RRB- Gauer - Henry reflex gauge boson gauge theory gauss (unit) Gauss, Carl Friedrich (1777 — 1855) Gaussian distribution Gay - Lussac, Joseph Louis (1778 — 1850) GCOM (Global Change Observing Mission) Geber (c. 720 — 815) gegenschein Geiger, Hans Wilhelm (1882 — 1945) Geiger - Müller counter Giessler tube gel gelatin Gelfond's theorem Gell - Mann, Murray (1929 ---RRB- GEM «gemination,»
of martian canals Geminga Gemini (constellation) Gemini Observatory Gemini Project Gemini - Titan II gemstone gene gene
expression gene mapping gene pool gene therapy gene transfer General Catalogue
of Variable Stars (GCVS) general precession general theory
of relativity generation ship generator Genesis (inflatable orbiting module) Genesis (sample return probe) genetic code genetic counseling genetic disorder genetic drift genetic engineering genetic
marker genetic material genetic pool genetic recombination genetics GENETICS AND HEREDITY Geneva Extrasolar Planet Search Program genome genome, interstellar transmission
of genotype gentian violet genus geoboard geode geodesic geodesy geodesy satellites geodetic precession Geographos (minor planet 1620) geography GEOGRAPHY Geo - IK geologic time geology GEOLOGY AND PLANETARY SCIENCE geomagnetic field geomagnetic storm geometric mean geometric sequence geometry GEOMETRY geometry puzzles geophysics GEOS (Geodetic Earth Orbiting Satellite) Geosat geostationary orbit geosynchronous orbit geosynchronous / geostationary transfer orbit (GTO) geosyncline Geotail (satellite) geotropism germ germ cells Germain, Sophie (1776 — 1831) German Rocket Society germanium germination Gesner, Konrad von (1516 — 1565) gestation Get Off the Earth puzzle Gettier problem geyser g - force GFO (Geosat Follow - On) GFZ - 1 (GeoForschungsZentrum) ghost crater Ghost Head Nebula (NGC 2080) ghost image Ghost
of Jupiter (NGC 3242) Giacconi, Riccardo (1931 ---RRB- Giacobini - Zinner, Comet (Comet 21P /) Giaever, Ivar (1929 ---RRB- giant branch Giant Magellan Telescope giant molecular cloud giant planet giant star Giant's Causeway Giauque, William Francis (1895 — 1982) gibberellins Gibbs, Josiah Willard (1839 — 1903) Gibbs free energy Gibson, Edward G. (1936 ---RRB- Gilbert, William (1544 — 1603) gilbert (unit) Gilbreath's conjecture gilding gill gill (unit) Gilruth, Robert R. (1913 — 2000) gilsonite gimbal Ginga ginkgo Giotto (ESA Halley probe) GIRD (Gruppa Isutcheniya Reaktivnovo Dvisheniya) girder glacial drift glacial groove glacier gland Glaser, Donald Arthur (1926 — 2013) Glashow, Sheldon (1932 ---RRB- glass GLAST (Gamma - ray Large Area Space Telescope) Glauber, Johann Rudolf (1607 — 1670) glaucoma glauconite Glenn, John Herschel, Jr. (1921 ---RRB- Glenn Research Center Glennan, T (homas) Keith (1905 — 1995) glenoid cavity glia glial cell glider Gliese 229B Gliese 581 Gliese 67 (HD 10307, HIP 7918) Gliese 710 (HD 168442, HIP 89825) Gliese 86 Gliese 876 Gliese Catalogue glioma glissette glitch Global Astrometric Interferometer for Astrophysics (GAIA) Global Oscillation Network Group (GONG) Globalstar globe Globigerina globular cluster globular proteins globule globulin globus pallidus GLOMR (Global Low Orbiting Message Relay) GLONASS (Global Navigation Satellite System) glossopharyngeal nerve Gloster E. 28/39 glottis glow - worm glucagon glucocorticoid glucose glucoside gluon Glushko, Valentin Petrovitch (1908 — 1989) glutamic acid glutamine gluten gluteus maximus glycerol glycine glycogen glycol glycolysis glycoprotein glycosidic bond glycosuria glyoxysome GMS (Geosynchronous Meteorological Satellite) GMT (Greenwich Mean Time) Gnathostomata gneiss Go Go, No - go goblet cell GOCE (Gravity field and steady - state Ocean Circulation Explorer) God Goddard, Robert Hutchings (1882 — 1945) Goddard Institute for Space Studies Goddard Space Flight Center Gödel, Kurt (1906 — 1978) Gödel universe Godwin, Francis (1562 — 1633) GOES (Geostationary Operational Environmental Satellite) goethite goiter gold Gold, Thomas (1920 — 2004) Goldbach conjecture golden ratio (phi) Goldin, Daniel Saul (1940 ---RRB- gold - leaf electroscope Goldstone Tracking Facility Golgi, Camillo (1844 — 1926) Golgi apparatus Golomb, Solomon W. (1932 — 2016) golygon GOMS (Geostationary Operational Meteorological Satellite) gonad gonadotrophin - releasing hormone gonadotrophins Gondwanaland Gonets goniatite goniometer gonorrhea Goodricke, John (1764 — 1786) googol Gordian Knot Gordon, Richard Francis, Jr. (1929 — 2017) Gore, John Ellard (1845 — 1910) gorge gorilla Gorizont Gott loop Goudsmit, Samuel Abraham (1902 — 1978) Gould, Benjamin Apthorp (1824 — 1896) Gould, Stephen Jay (1941 — 2002) Gould Belt gout governor GPS (Global Positioning System) Graaf, Regnier de (1641 — 1673) Graafian follicle GRAB graben GRACE (Gravity Recovery and Climate Experiment) graceful graph gradient Graham, Ronald (1935 ---RRB- Graham, Thomas (1805 — 1869) Graham's law
of diffusion Graham's number GRAIL (Gravity Recovery and Interior Laboratory) grain (cereal) grain (unit) gram gram - atom Gramme, Zénobe Théophile (1826 — 1901) gramophone Gram's stain Gran Telescopio Canarias (GTC) Granat Grand Tour grand unified theory (GUT) Grandfather Paradox Granit, Ragnar Arthur (1900 — 1991) granite granulation granule granulocyte graph graph theory graphene graphite GRAPHS AND GRAPH THEORY graptolite grass grassland gravel graveyard orbit gravimeter gravimetric analysis Gravitational Biology Facility gravitational collapse gravitational constant (G) gravitational instability gravitational lens gravitational life gravitational lock gravitational microlensing GRAVITATIONAL PHYSICS gravitational slingshot effect gravitational waves graviton gravity gravity gradient gravity gradient stabilization Gravity Probe A Gravity Probe B gravity - assist gray (Gy) gray goo gray matter grazing - incidence telescope Great Annihilator Great Attractor great circle Great Comets Great Hercules Cluster (M13, NGC 6205) Great Monad Great Observatories Great Red Spot Great Rift (in Milky Way) Great Rift Valley Great Square
of Pegasus Great Wall greater omentum greatest elongation Green, George (1793 — 1841) Green, Nathaniel E. Green, Thomas Hill (1836 — 1882) green algae Green Bank Green Bank conference (1961) Green Bank Telescope green flash greenhouse effect greenhouse gases Green's theorem Greg, Percy (1836 — 1889) Gregorian calendar Grelling's paradox Griffith, George (1857 — 1906) Griffith Observatory Grignard, François Auguste Victor (1871 — 1935) Grignard reagent grike Grimaldi, Francesco Maria (1618 — 1663) Grissom, Virgil (1926 — 1967) grit gritstone Groom Lake Groombridge 34 Groombridge Catalogue gross ground, electrical ground state ground - track group group theory GROUPS AND GROUP THEORY growing season growth growth hormone growth hormone - releasing hormone growth plate Grudge, Project Gruithuisen, Franz von Paula (1774 — 1852) Grus (constellation) Grus Quartet (NGC 7552, NGC 7582, NGC 7590, and NGC 7599) GSLV (Geosynchronous Satellite Launch Vehicle) g - suit G - type asteroid Guericke, Otto von (1602 — 1686) guanine Guiana Space Centre guidance, inertial Guide Star Catalog (GSC) guided missile guided missiles, postwar development Guillaume, Charles Édouard (1861 — 1938) Gulf Stream (ocean current) Gulfstream (jet plane) Gullstrand, Allvar (1862 — 1930) gum Gum Nebula gun metal gunpowder Gurwin Gusev Crater gut Gutenberg, Johann (c. 1400 — 1468) Guy, Richard Kenneth (1916 ---RRB- guyot Guzman Prize gymnosperm gynecology gynoecium gypsum gyrocompass gyrofrequency gyropilot gyroscope gyrostabilizer Gyulbudagian's Nebula (HH215)
Cultured mouse, monkey, and human pluripotent cells can be driven down a retinal lineage as determined by the
expression of marker genes, including the EFTFs [2]--[4].
The
expression patterns
of cell class - specific
markers in mosaic retinas appeared the same in host and donor derived regions suggesting that donor cells generated all retinal cell classes in approximately normal ratios (Figures 5K — 5N and S2).
Normal anatomical structure and the
expression of cell class - specific
markers does not demonstrate normal cellular function and connectivity.
We are examining the effect
of a maximal exercise stress test on gene
expression, metabolism, inflammatory
markers, and cytokine levels in ME / CFS patients and healthy controls.
We recommend confirming the presence
of the transgene by PCR or examination
of the cell line microscopically for fluorescent
marker expression.
Expression of the Wnt inhibitor Dickkopf - 1 is required for the induction
of neural
markers in mouse embryonic stem cells differentiating in response to retinoic acid.
Current projects are investigating: 1) the
expression of inflammatory genes during ischemia and reperfusion
of kidneys during urology transplantation and in mouse models; 2) the
expression of inflammatory genes and proteins in urine as
markers indicating the presence
of rejection in renal allografts; and 3) the role
of adhesion molecules and chemokines in directing leukocyte infiltration into organ allografts.
Interestingly, transient BIO exposure (1 — 2 hours) prompted accelerated WNT signaling in hMSCs and stimulated the
expression of early osteogenic
markers, such as the osteogenic master - regulator Runx2.
When overexpressed together in developing Xenopus embryos by RNA microinjection, these genes can induce eye - like structures as defined by the
expression of markers for some retinal cell classes [7].
Ihor Zahanich (Ravens, TUD)-- «Differentiation potential
of human mesenchymal stem cells:
expression of molecular
markers, ion channels and gap junction channels» (2006)
Aberrant
expression of TUBB3 has also been found in various tumors
of non-neural origin and can be used as a biomarker for cancer aggressiveness and a
marker for the tendency to respond poorly to chemotherapy.