Oral administration
of mebendazole in mice elicited a strong antitumor effect in a subcutaneous model and reduced lesions in experimentally induced lung metastasis without any toxicity when compared with paclitaxel - treated mice [9,20].
Several studies demonstrated potent antitumor properties
of mebendazole (Table 1).
Dosing
of mebendazole of 30 - 87 mg / kg / day in humans resulted in plasma levels of 120 -218 nM (260 nM for continuous administration) with coefficients of variation ranging from 27 to 72 %.
Tan Z, Chen L, Zhang S. Comprehensive modeling and discovery
of mebendazole as a novel TRAF2 - and NCK - interacting kinase inhibitor.
Not exact matches
In a previous paper published in ecancermedicalscience, the ReDO researchers examined the anti-cancer properties
of the drug
mebendazole, an over-the-counter treatment currently used for threadworm.
Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission
of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research
of a reformulated form
of flubendazole for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation
of Vermox (
mebendazole) that will facilitate treatment
of intestinal worms in younger children.
Long - term follow - up
of plasma
mebendazole levels and drug interactions.
Correspondingly, the in vivo growth
of hedgehog - dependent medulloblastoma was inhibited by orally administered
mebendazole.
In human cells,
mebendazole suppressed the formation
of the primary cilium, a microtubule - based organelle that functions as a signaling hub for Hh pathway activation.
The benzamidazole
mebendazole significantly inhibited growth
of adrenocortical carcinoma cells, both in vitro and in vivo, the effects being due to induction
of apoptosis [19].
Furthermore, the host
of different targets described seems to be linked to the capability
of the benzimidazoles (
mebendazole), salicylanilides (niclosamine) and cyanine dye derivatives (pyrvinium) to interact with DNA directly.
Anticancer activities
of anthelminthics were reported for
mebendazole by Mukhopadhyay et al. in 2002, for pyrvinium pamoate (PPAM) by Esumi et al. in 2004 and for niclosamide by Wang et al. in 2009, respectively [8 - 10].
Examples
of drugs identified as high - potential agents within the Repurposing Drugs in Oncology (ReDO) project include
mebendazole, cimetidine, nitroglycerin, diclofenac and clarithromycin, among others [3].
Treatment
of lung cancer cell lines with
mebendazole caused mitotic arrest by depolymerization
of tubulin, followed by apoptotic cell death.
Moreover,
mebendazole inhibited invasion and migration
of cancer cells in vitro, and formation
of metastases in vivo in experimental animals.
In the conventional world
of medicine, one
of the mainstays is
mebendazole.
Treatment involves deworming with one
of several products:
mebendazole (Telmintic ®), fenbendazole (Panacur ®), pyrantel pamoate (Nemex ®, Drontal ®, or Strongid T ®).
Reducing intestinal nematode infection: efficacy
of albendazole and
mebendazole (Review).