In proposals to develop APM, this problem will be solved by guided molecular trajectories and positionally - controlled mechanosynthesis: reactive molecular fragments will be guided by molecular machine systems to a specific position and geometric orientation with respect to the growing atomically precise work piece so that the application
of mechanical force will cause the desired bond to form.
Being able to literally pull apart these triazoles into their constituent precursors and then unlock their chemical reactivity in new ways is now possible with the assistance
of mechanical force,» he says.»
The pattern generates a small but potent amount
of mechanical force that shows cells where to line up.
When Enlightenment thinkers decided that the whole of nature operates in terms
of mechanical forces, they concluded that the apparent difference between organisms and mechanisms is only apparent.
Bioengineer David Kaplan at Tufts University's Department of Biomedical Engineering, who had no role in these findings, calls the work «fantastic» and adds future research might want the bioreactor to mimic the same range
of mechanical forces this bone will see if implanted — for instance, for the jaw joint, «you'd want it to experience compression and torsion.»
And the impact
of mechanical forces on development is being increasingly studied in a variety of organisms, Goentoro says.
«Symmetrization is a combination
of the mechanical forces created by the muscle contractions and the viscoelastic jellyfish body material,» Abrams says.
These observations suggested the toe is twisted as a result
of mechanical forces imposed on it by the embryonic musculature.
«The role
of mechanical forces in the behaviour of biological cells has long been overlooked, but then has become a rapidly growing field of research over the last two decades now known as mechanobiology,» states Prof. Schwarz.
Because
of the mechanical forces of movement and weight bearing, these matrix components are constantly being replenished in order to maintain strength and resilience.
Not exact matches
The incident followed a Friday scare at JFK, in which an American Airlines flight was
forced to land shortly after takeoff because
of a
mechanical issue.
After serving in the Air
Force for three years, Berthold graduated from the University
of New Mexico in 1985 with a degree in
mechanical engineering and went to work in professional car racing.
Hitler is an example
of a pure necrophile who was passionately fascinated by
force,
mechanical things, killing, and death.
Certainly it is true that the more a
mechanical force acts on a thing in a purely
mechanical way, the more the autonomy
of the thing is diminished.
Thanks to the
mechanical devices which we increasingly charge with the burden not only
of production but also
of calculation, the quantity
of unused human energy is growing at a disturbing rate both within us and around us; and this phenomenon will reach its climax in the near future, when nuclear
forces have been harnessed to useful work.
The behavior
of the clock is to be explained in detail by the
mechanical forces operating among its parts.
It does assert something about the world to say that two parameters such as
force and mass can be deployed in such a way as to predict or describe a large class
of mechanical phenomena.
In every sphere, physical no less than intellectual and moral, and whether it be a question
of flowing water, a traveler on a journey, or a thinker or mystic engaged in the pursuit
of truth, there inevitably comes a point in time and place when the necessity presents itself, to
mechanical forces, or to our freedom
of choice,
of deciding once and for all which
of two paths is the one to take.
In the Newtonian universe, once the initial conditions and the laws
of force are given, everything is interpreted in terms
of the
mechanical movements
of atoms and molecules and all is calculable for ever before and after.
This is certain, that it must proceed from a cause that penetrates to the very centres
of the sun and planets, without suffering the least diminution
of its
force; that operates not according to the quantity
of the surfaces
of the particles upon which it acts (as
mechanical causes use to do), but according to the quantity
of the solid matter which they contain, and propagates its virtue on all sides to immense distances, decreasing always as the inverse square
of the distances....
Between them the Christian understanding
of human being and society as created, fallen and redeemed by God was made irrelevant so that these
forces of modernity were left to be interpreted solely within the framework
of the humanism
of the Enlightenment which at best had a Deistic faith coupled with a
mechanical view
of the world and a self - redemptive idea
of history making for an optimistic doctrine
of inevitable progress.
There are some, he tells us, who argue that the causes
of his actions are the
mechanical forces on his bones and muscles and sinews.
This year the publication joined
forces with the Institute
of Mechanical Engineers to create the UK's largest manufacturing awards programme.
Mechanical forces during intra-uterine life and during birth may negatively affect the oral - motor function
of the newborn.
Presented Physics,
Forces, and
Mechanical Effects
of Birth on Breastfeeding.
It is true, we were, we are, overwhelmed by the
mechanical, ground and air
forces of the enemy.
They are very proud
of their son, an Air
Force veteran, and their three daughters: a hotshot firefighter, an industrial engineer, and a student
of mechanical engineering at SUNY Binghamton.
By fiddling with the cytoskeletons
of real - life hydras, researchers found that the pond polyps rely on
mechanical forces as well as molecular cues to regenerate head and tentacles in the right places (SN: 3/4/17, p. 19).
Donald Ingber, M.D., Ph.D., Founding Director
of the Wyss Institute at Harvard University, started investigating this «architecture
of life» over thirty - five years ago, and discovered that Nature uses an architectural principle known as «tensegrity» (short for «tensional integrity») to stabilize the shapes
of living cells and to determine how they respond to
mechanical forces.
Since the start
of the team's most recent INCITE project, Alexeev is also helping them validate a
force field (the sets
of parameters needed to accurately calculate the energy functions) for peptide design against quantum
mechanical simulations.
Engler's team, which includes bioengineering graduate student researchers Ludovic Vincent and Jessica Wen, found that the stem cell differentiation is a response to the
mechanical deformation
of the hydrogel from the
force exerted by the cell.
This
mechanical forcing applied to the whole planet causes strong currents in the outer core, which is made up
of a liquid iron alloy
of very low viscosity.
At the University
of Cologne, biophysicists in the lab
of Professor Berenike Maier were now able to show how differential
mechanical forces can lead to cell sorting in biofilms, thereby determining their architecture.
The group is now pursuing studies that couple the
mechanical forces of a blast, or pressure wave, to the activation
of chemical - signaling pathways in neural cells.
In their publication in the journal eLife, the team headed by the biophysicist Enno Oldewurtel showed how specific
mechanical forces can be the key to the structure
of a biofilm.
In a mix
of bacteria that interact with each other to different degrees, the cells sorted themselves according to the
mechanical forces they exerted among one another.
Now that has changed: Forward thinkers see it as an important energizer for the tiniest
of machines, devices on the nano scale, and a few labs are working on ways to use the
force to defy the conventional limitations
of mechanical design.
«In a way, one must learn to see things from the molecules» point
of view, considering
forces such as random thermal motion that one would never consider when building an agricultural water pump or any other
mechanical device.»
By carefully controlling the composition
of the droplets and the strength
of the magnetic field, the
forces applied by the droplet can be controlled, and the response
of the surrounding tissue reveals its
mechanical characteristics as well as the cues that cells are exposed to as the tissue grows.
Folds or wrinkles in a surface are the result
of mechanical instability — compression
forces applied to some part
of the material.
The result may lead to ultrasensitive
force detectors and to ways
of controlling an object's
mechanical vibrations as deftly as we now control electricity and light.
But there may be a way to cut drag
force by almost 30 %, according to computer simulations
of turbulent ocean - water flows reported in the 19 May issue
of Science by
mechanical engineer Yiqing Du
of the Massachusetts Institute
of Technology and applied mathematician George Karniadakis
of Brown University.
Mathematical modeling reveals the
mechanical forces that guide the development
of mollusk spirals, spines and ribs
«The problem with regular turbines is the bigger they get, the harder they work, and the more likely the
force of the water is to damage the turbine,» says Andrew Grant, an ESRU
mechanical engineer.
The scientists had produced
mechanical defects in the particles first in simulations by high - power computers and then, in reality, with the measurement tip
of a scanning
force microscope.
Understanding the protein's effects on genes is just one piece
of the puzzle: The effects
of physical and
mechanical forces on cancer progression is a burgeoning, but still new, area
of research.
A series
of biochemical experiments found that the
mechanical force disrupted proteins called integrins that help anchor cells to the scaffold
of protein that surrounds them.
In experiments with muscle cells from the lining
of blood vessels, the researchers found that a sudden
mechanical force flips a genetic switch in these cells, making them more likely to contract.
Until recently, it was unclear how the physical pressure
of a light touch gets transduced from a
mechanical force to an electrical nerve signal in Merkel discs.
In 2014, Gu's research team overturned the common assumption that transduction from the
mechanical force takes place at the endings
of the sensory nerves in Merkel discs.