Sentences with phrase «of mechanisms of cancer»

While further research is needed to understand the effectiveness of H1.0 protein in preventing the spread of cancer growth, this research advances significantly the study of the mechanisms of cancer stem cells and the relatively new epigenetic approach to cancer research.

Not exact matches

Tecentriq belongs to a class of drugs called PD - 1 inhibitors, which help the immune system to fight cancer by blocking a mechanism that tumors use to evade attack.

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

Through a variety of mechanisms, a healthy gut has been shown to improve immune function, fight certain forms of cancer, prevent diabetes, increase fat metabolism and encourage a healthy body weight.

Similar to capsaicin, tumor necrosis factor is suspected to both induce and reduce cancer cell growth, and was shown to commit cells to survival when stimulating EGFR transactivation mechanisms, indicating that EGFR could act as a molecular switch determining the antiapoptotic effect of tumor necrosis factor (50).

However, the molecular mechanisms of the cancer - promoting effects of capsaicin are not clear.

Exposure of the skin to ultraviolet B wavelengths from sunlight is the usual mechanism for production of vitamin D. However, significant risk of sunburn (short - term) and skin cancer (long - term) attributable to sunlight exposure, especially in younger children, makes it prudent to counsel against exposure to sunlight.

«This novel technique,» they said, «should help distinguish and monitor cancer stages and progression, aid in elucidation of basic mechanisms underlying tumorigenesis, and facilitate analyses of processes related to early detection of cancer, screening and / or cancer risk assessment.»

«Mechanism triggering spread of prostate cancer to bones found: Activated enzyme responds well to treatment.»

The NAS finished reviewing the EPA assessment in April, sending back a long list of questions and advising the EPA not to finalize the document until it could show exactly how formaldehyde causes cancer, a biological mechanism known as the «mode of action.»

The findings, published in Proceedings of the National Academy of Sciences (PNAS), define a mechanism in which the oncogenes turn on a protein called RSK2 that is required for cancer cells to move.

Seeking one mechanism to explain the induction of cancer by many different agents, Huebner and Todaro had suggested that retrovirus oncogenes are a part of the genetic baggage of all cells, perhaps acquired through viral infection early in evolution.

What has been learned from oncogenes represents the first peep behind the curtain that for so long has obscured the mechanisms of cancer.

He is hopeful that if better understood, these biological mechanisms could illuminate new ways of treating cancer.

These results have important implications for the understanding of the mechanisms controlling tumour heterogeneity and the development of new strategies to block PIK3CA induced breast cancer.

A Ludwig Cancer Research study led by Benoit Van den Eynde, Director of Ludwig Brussels, has identified a novel mechanism by which tumors of the aggressive skin cancer melanoma can resist cancer immunothCancer Research study led by Benoit Van den Eynde, Director of Ludwig Brussels, has identified a novel mechanism by which tumors of the aggressive skin cancer melanoma can resist cancer immunothcancer melanoma can resist cancer immunothcancer immunotherapy.

This work confirmed these suspicions and discovered novel molecular genetic mechanisms driving the evolution of HPV - inactive cancers.

One of the key questions in cancer biology is to understand the mechanisms that control tumor heterogeneity and to determine to which extend tumor heterogeneity influences clinical outcome.

The Cent - 1 molecule kills cancer cells through a mechanism similar to that of the template drug Rigosertib that is currently under commercial development.

Notably, the mechanism was clearly associated with poor outcome in patients with the blood cancer myeloma, where proteasome inhibitors are a mainstay of treatment.

«Naturally occurring mechanism of cancer drug - resistance may itself be a treatment target.»

This could be key given that the underlying mechanisms of metastasis and resistance to cancer drugs are nothing if not complex interactions in a biological system.

«We've long known that NF - kB promotes cancer development by subverting apoptosis, an internal safety mechanism that otherwise would cause cancer cells to self - destruct,» says principal investigator Denis Guttridge, PhD, professor of molecular virology, immunology and medical genetics and of molecular and cellular biochemistry.

A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibCancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibCancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibcancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

Researchers at Roswell Park Cancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast cCancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast ccancer cells that leads to chemotherapy resistance in inflammatory breast cancercancer.

Ironically, because of its pivotal role in coordinating a range of cancer - fighting mechanisms in the human body, it is also one of the most important cancer - causing genes when mutated.

In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.

Although proteasome inhibitors are very efficient in selective killing of cancer tumor cells grown in a dish (in - vitro), their success in the clinic has largely been undermined by the development of resistance — mechanisms of which are poorly understood.

We hope that these new insights will allow us to increase our understanding of the molecular mechanisms that result in cancer and to more effectively treat this aggressive type of leukemia.»

A number of biological mechanisms link obesity to endometrial cancer.

Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery.

«Our work suggests a mechanism for cell lethality involving the regulation of BCAAs as crucial elements in pancreatic cancer by regulating ME3,» said Ronald DePinho, M.D., professor of Cancer Biology, senior author of the Nature paper and president of MD Andcancer by regulating ME3,» said Ronald DePinho, M.D., professor of Cancer Biology, senior author of the Nature paper and president of MD AndCancer Biology, senior author of the Nature paper and president of MD Anderson.

«We are asking the body to override these existing control mechanisms,» says Mark Kelley of Vanderbilt - Ingram Cancer Center in Nashville, Tenn., who was involved with the failed Canvaxin studies.

«Dr. Rassool and her colleagues have identified an exciting new mechanism for attacking cancer that may ultimately provide a new option for treating patients with leukemia and other cancers,» says E. Albert Reece, MD, PhD, MBA, vice president for medical affairs at the University of Maryland and the John Z. and Akiko K. Bowers Distinguished Professor and dean of UMSOM.

Adult drug resistant cancer cells may contribute to this problem, and the authors discuss these and other cancer drug resistance mechanisms in their recent publication in the September issue of the journal Cancers.

A better understanding of the mechanism that accelerates or restricts the development of cancer may allow, for example, the discovery of new biomarkers to better identify the population at greatest risk of colon cancer and even the current degree of risk.

«Our computer aided drug screening process has now identified two new classes of anti-cancer agents, specifically targeting two distinct and novel mechanisms underpinning cancer,» said Dr Andrea Brancale from Cardiff University's School of Pharmacy, who led on the compound's design.

When radioisotopes lodge in certain organs — such as iodine - 131 in the thyroid gland — the constant bombardment of surrounding tissue can overwhelm repair mechanisms and trigger cancer.

Using genome data from more than 50,000 cancer cases and 60,000 controls through the GAME - ON (Genetic Associations and Mechanisms in Oncology) network, the team compared telomere lengths with the risk of developing breast, lung, colorectal, ovarian and prostate cancers, including subtypes.

One of the goals of the Center for Chromosome Biology is to establish screening techniques using small interfering RNAs (siRNAs) to find new targets for anticancer drugs, as well as gain a better understanding of fundamental cancer mechanisms.

«We reasoned that if we could identify microRNAs that regulate the progression of colorectal cancer, we could use them as molecular probes to better understand the molecular and cellular mechanisms that govern liver colonization,» says Tavazoie, who is Leon Hess Associate Professor and head of the Elizabeth and Vincent Meyer Laboratory of Systems Cancer Bicancer, we could use them as molecular probes to better understand the molecular and cellular mechanisms that govern liver colonization,» says Tavazoie, who is Leon Hess Associate Professor and head of the Elizabeth and Vincent Meyer Laboratory of Systems Cancer BiCancer Biology.

Along with finding that the tumor suppressor protein SIRT6 is inactive in around 30 percent of cases of pancreatic ductal adenocarcinoma (PDAC), the team identified the precise pathway by which SIRT6 suppresses PDAC development, a mechanism different from the way it suppresses colorectal cancer.

However, additional research, including more formal mediation analyses, on the underlying mechanisms for the recreational physical activity - cancer association should be pursued vigorously,» writes Marilie D. Gammon, Ph.D., of the University of North Carolina at Chapel Hill Gillings School of Public Health, and coauthors in a related commentary.

First, a review and summary of the literature on the biological mechanisms by which alcohol affects the risk of breast cancer showed that alcohol affects breast - cancer risk through the alteration of hormone levels and the associated biological pathways, carcinogens generated during the metabolism of ethanol, and the inhibition of the one - carbon metabolism pathway.

«These results highlight RNA editing as an exciting theme for investigating cancer mechanisms, biomarkers and treatments,» said Han Liang, Ph.D., associate professor of Bioinformatics and Computational Biology.

«Further research into the detailed mechanisms underlying ASIS in naked mole - rats may shed new light on cancer resistance in the mole - rats and contribute to the generation of non-tumorigenic human - iPSCs, enabling safer cell - based therapeutics,» said Kyoko Miura, an assistant professor at Hokkaido University.

Researchers targeting colorectal cancer stem cells — the root cause of disease, resistance to treatment and relapse — have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.

The work published in Cancer Cell complements previous research efforts from the CNIO Melanoma Group, which could lead to the development of novel drugs that selectively target the mechanism of cell autodigestion as a potential therapeutic strategy.

«Next steps are to further explore this possibility in human trials in order to assess if it will help patients, but these two drugs make sense from a variety of studies and we find that they act together through multiple mechanisms to control cancer growth in the laboratory.»

Autophagy has emerged as a key pathway that cancer cells use to survive in the face of assault by chemotherapy and radiation; however, autophagy as a potential druggable mechanism in patients who become resistant to BRAF inhibitors has not been investigated.