Sentences with phrase «of melanoma cell lines»

Interestingly, two studies of melanoma cell lines revealed frequent mutations in mitogen activated protein (MAP) kinase kinase [kinase] genes MAP2K1, MAP2K2, MAP3K5, and MAP3K9.

Not exact matches

When the researchers did the opposite, turning on a PAK protein in a metastatic melanoma cell line, they found the cells became even more resistant to inhibitors of the MAPK pathway.

Beyond lung cancer, TiY is able to target TICs in 28 types of human cell lines derived from the central nervous system, melanoma, breast, renal, ovarian, colon, and prostate cancer.

The researchers also examined BRAF mutant melanoma cell lines, and found that BRAF inhibition induced autophagy by way of an endoplasmic reticulum (ER) stress response.

CNIO's Bioinformatics Unit has been key in comparing 900 cell lines derived from up to 35 tumor types in order to identify unique aspects of melanoma.

To test their hypothesis, the researchers carried out experiments on human melanoma cells, a line of cancer cells they chose for their ability to grow easily and quickly.

After exploiting a technology that allowed them to activate each of nearly 16,000 genes individually in human melanoma cell lines containing mutant BRAF, the authors then treated the panel of cells with the drugs and monitored which cells showed altered drug sensitivity.

He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds of cancer cell lines, not just melanoma, and look for novel combinations that will benefit subsets of patients regardless of the particular type of tumor they have.

This study utilized 36 well - characterized melanoma cell lines assembled by the MGH Center for Molecular Therapeutics to test all possible combinations of more than 100 oncology drugs, two - thirds of which are currently in clinical use.

Methods: Mouse melanoma cell line B16F10 was exposed to 1.0, 2.0 and 3.0 Gy of electron beam radiation.

Mouse melanoma cell line B16F10 was procured from National Centre for Cell Science, Pune, India as well as from Department of Radiation Biology and Toxicology, School of Life Sciences, Manipal, Incell line B16F10 was procured from National Centre for Cell Science, Pune, India as well as from Department of Radiation Biology and Toxicology, School of Life Sciences, Manipal, InCell Science, Pune, India as well as from Department of Radiation Biology and Toxicology, School of Life Sciences, Manipal, India.

In this study, we present data from screening 810 genetically - modified mouse lines with the experimental metastasis assay where intravenous delivery of murine metastatic melanoma B16 - F10 cells was used to assess the formation of pulmonary metastasic foci.

Oral Melanoma — Melanomas are aggressive cancers of the melanocyte cells — those octopus - shaped, pigment - producing body cells that line the bottom layer of the epidermis, the first layer of skin.