Sentences with phrase «of metabolic»

He has also edited the 6th, 7th, and 8th editions of The Metabolic Basis of Inherited Disease, a core genetics textbook, and since 2001 has served as editor - in - chief of the online version of Scriver's Metabolic and Molecular Bases of Inherited Disease.

The Metabolomics & Proteomics Technology Unit activity focus on the identification of biomarkers and the functional characterization of metabolic pathways, applied to Research & Development of antimicrobials, vaccines, diagnostic tests or probiotics.

The University of Cambridge Metabolic Research Laboratories, Wellcome Trust - MRC Institute of Metabolic Science, Cambridge, UK.

Symptoms of metabolic syndrome (glucose intolerance) were observed in IVC F0, F1, and F2 male mice.

Receiver operating characteristic curves were used to derive optimal WC cut - points for detecting the presence of at least two components of metabolic syndrome (MS), excluding WC.

WNIN / Gr - Ob rats demonstrate features of metabolic syndrome that include obesity, insulin resistance, impaired glucose tolerance, and hyperinsulinemia.

Amyloid - β is one of the forms of metabolic waste that accumulates in Alzheimer's disease.

Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge.

After a postdoctoral training at University of California with Professor Jay D. Keasling, Dr. Lee became a Scientist at Lawrence Berkeley National Laboratory in 2008 and joined as a Director of Metabolic Engineering at the Joint BioEnergy Institute (JBEI).

Positron emission tomography (PET) imaging of metabolic tumor burden at diagnosis and after induction therapy can help identify patients most at risk of follicular lymphoma (FL) recurrence, but more work is needed to differentiate high - risk and moderate - risk patients, suggested findings from a pooled analysis of data from three prospective clinical trials, published in Blood.

The Joslin team went on to study the effect of metabolic stress on signs of aging.

The outcome of this maladaptation is a feedforward inflammatory response leading to a state of unresolved inflammation and a collection of metabolic pathologies, including insulin resistance, fatty liver, atherosclerosis and dyslipidaemia.

We speculate this to be the case, as resetting of metabolic abnormalities is needed for recovery of IBD patients who have metabolic syndrome disorder (Goncalves et al., 2015).

This pathway allows glutamine to be converted into a variety of metabolic intermediates such as aspartate, asparagine, citrate and oxaloacetate and pyruvate [103].

Prof. Sir Stephen O'Rahilly MD FRS FMedSci, Professor of Clinical Biochemistry and Medicine and Director of the Metabolic Research Laboratories, University of Cambridge, said:

She has extensive experience in the fields of metabolic disorders and cancer biology through her work at Connexios Life Sciences, the New York University School of Medicine, and the Mount Sinai Medical Center.

The misacylation or poor activity of mitochondrial SRS in humans is responsible for a variety of metabolic diseases.

Development of inhibitors of metabolic pathways to block oncogenes or signalling molecules in malignant processes and specific inflammatory processes, such as pulmonary artery hypertension or idiopathic pulmonary fibrosis.

Group research aims to study the relations between nutraceuticals, physical activity, intracellular mechanisms, gene expression and microbiota using a translational approach to characterize the impact in the whole body of metabolic interactions studied in individual organs and tissues (in vitro / ex vivo: skeletal muscle, heart, bone, liver and kidney).

The scientists also identified molecular signatures of metabolic evolution.

We publish polished, concise, highly read and cited articles of topics at the cutting edge of metabolic diseases covering both clinical and research aspects of the field; from state - of - the - art treatments of endocrine diseases to new developments in molecular biology.

Lewandowski's team examined the effects of artificially stressing the heart on several indicators of metabolic health, and found that at early stages, they're all good — increased glucose tolerance and insulin sensitivity and changes in fat that make it burn energy.

The findings were published in Molecular Systems Biology and could lead to new probiotic - delivering foods, and a better understanding of the metabolic processes behind diseases such as type 2 diabetes.

Hartmut Foerster, a research associate in the Mueller lab also attended PAG and presented his work on MetaCyc, a multi-species database, and SolCyc, a set of databases of Solanaceae plants, which contain information on thousands of metabolic pathways.

Studies of metabolic regulation, and of the cells and neuronal circuits that respond to CO2 and O2 and modulate breathing and blood flow.

The very high levels of metabolic activity may have implications for the development of autoimmunity and malignancy, both of which occur at higher frequency in patients with GLILD.

This appears to be due to either a mutation in the leptin receptor, or some other downstream inhibition of the receptor signaling that leads to a resistance to leptin action; this leads to a number of metabolic changes.

A drug known as SR9009, which is currently under development at The Scripps Research Institute (TSRI), increases the level of metabolic activity in skeletal muscles of mice.

The persistent bacteria uses an enzyme called isocitrate lyase (ICL) as part of a metabolic pathway that breaks down fatty acids for energy.

High prevalence of metabolic syndrome in first - degree male relatives of women with polycystic ovary syndrome is related to high rates of obesity

Dr. Brady's accomplishments include the identification of the metabolic defects in hereditary lipid storage disorders including Gaucher disease, Niemann - Pick disease, Fabry disease, and Tay - Sachs disease.

Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild - type mice.

Here we present the genome of E. histolytica, which reveals a variety of metabolic adaptations shared with two other amitochondrial protist pathogens: Giardia lamblia and Trichomonas vaginalis.

Endogenous androgens and sex hormone - binding globulin in women and risk of metabolic syndrome and type 2 diabetes

Cross-links are sugary compounds known as advanced glycation end - products that form in the extracellular matrix as a natural byproduct of metabolic processes.

With age - induced deterioration of glucose tolerance, sex differences are reduced, leading to more pronounced aggravation of the metabolic profile in women than in men (206, 207).

«All of the surrogate measures of metabolic health got better, just by substituting starch for sugar in their processed food — all without changing calories or weight or exercise,» study author Robert Lustig, a pediatric endocrinologist at UCSF Benioff Children's Hospital San Francisco, said in a statement.

Variability in the presence of the metabolic syndrome in type 2 diabetic patients attending a diabetes clinic.

Age and sex differences in the clustering of metabolic syndrome factors: association with mortality risk

Dr. Kurtzberg's research and clinical interests include using cord blood transplants for the treatment of metabolic diseases and cerebral palsy.

The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies

Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified.

These results will be correlated with the clinical and pathological characteristics of the patiens in order to determine if those patients which did not respond to conventional chemotherapeutical drugs have a higher de-regulation of metabolic reprogramming and / or autophagy.

Comparison of different definitions of the metabolic syndrome in relation to cardiovascular mortality in European men and women

An influence of genetic aspects is supported by higher prevalence of metabolic disorders in both male and female.

A birth cohort study to investigate the association between prenatal phthalate and bisphenol A exposures and fetal markers of metabolic dysfunction

The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of Pathway / Genome Databases — Ron Caspi — Nucleic Acids Research — November 2013

Background: WNIN / Gr - Ob rats demonstrate features of metabolic syndrome that include obesity, insulin resistance, impaired glucose tolerance, and hyperinsulinemia.

Relations of adiponectin to levels of metabolic parameters and sexual hormones in elderly type 2 diabetic patients

A comparison of metabolic pathways encoded by the genomes of T. brucei, T. cruzi, and Leishmania major reveals the least overall metabolic capability in T. brucei and the greatest in L. major.