In dogs and cats we have some knowledge of the structure of microbiomes and we now need a greater understanding in pets
of microbial function, host - microbe interactions and the role of nutrition.
Systemic toxicity — a side effect of extreme disruption
of microbial function throughout your body; beneficial microbes in particular, allowing for overgrowth of pathogens
The focus of the Microbiome Ideas Challenge is the development of new tools and methods that will help transition the field of microbiome research from correlative studies — i.e., genomics - driven microbial censusing efforts — to causal understanding
of microbial function.
Not exact matches
As ecosystems
of the human environment change during development, pregnancy, or with changing diets, which bacterial species remain or how these
microbial species
function may shift is slowly becoming understood.
The natural world
functions best with a rich diversity
of species, both at human scale and in the
microbial universe.
At the same time, altered water availability and enhanced photosynthesis can change the amount
of leaf, root and below ground
microbial biomass, resulting in changes to ecosystem
functioning.
Such predictions are «a
function of size, and we don't know size,» says
microbial geochemist Samantha B. Joye
of the University
of Georgia.
Using metabolic
function analyses
of identified genes, we compared our human genome with the average content
of previously sequenced
microbial genomes.
The human gut consists
of up to 100 trillion
microbial cells that influence metabolism, nutrition and immune
function.
The junk food diet also reduced the abundance
of microbial species capable
of metabolising flavonoids, which have been suggested to not only assist in weight loss but also exert neuro - protective
functions within the brain.
«Like a «Transformer», this protein
of the Ebola virus adopts different shapes for different
functions,» said Erica Ollmann Saphire, Ph.D., professor in the Department
of Immunology and
Microbial Science at TSRI.
Efforts to obtain and study genomes and enrichment cultures
of uncultivated
microbial lineages will likely further expand our knowledge about archaeal phylogenetic and metabolic diversity and their cell biology and ecological
function.
Sediment - covered basalt on the flanks
of mid-ocean ridges constitutes most
of Earth's oceanic crust, but the composition and metabolic
function of its
microbial ecosystem are largely unknown.
University
of British Columbia researchers may have discovered a key to understanding the constantly changing distribution
of microbial species in the world's oceans — classify microorganisms by their biochemical
function, rather than by their taxonomy.
A University
of British Columbia mathematician may have discovered a key to understanding the constantly changing distribution
of microbial species in the world's oceans — classify microorganisms by their biochemical
function, rather than by their taxonomy.
«The finding turns our view
of the
function of sex by 180 degrees,» says
microbial geneticist Joseph Heitman
of Duke University in Durham, North Carolina.
«We have become increasingly aware
of how crucially important a healthy gut
microbial population is for a well -
functioning immune system.
Working out the
functions of these
microbial genes is a big challenge because many
of the microbes that live within us are extremely reluctant to grow when cultured under laboratory conditions.
Hu et al. and Zhang et al. use cryo — electron microscopy to uncover the structural and biochemical basis
of two such receptors: NAIP2, which directly binds
microbial ligands, and NLRC4, a protein
functioning directly downstream.
The system is an evolutionarily ancient branch
of the immune response and a key
function is marking
microbial and dying host cells for elimination.
Elucidating
functions of commensal
microbial genes in the mammalian gut is challenging because many commensals are recalcitrant to laboratory cultivation and genetic manipulation.
The striking similarity
of the recipient's and donor's intestinal microbiota following after bacteriotherapy suggests that the donor's bacteria quickly occupied their requisite niches resulting in restoration
of both the structure and
function of the
microbial communities present.
Divergence
of dominant factors in soil
microbial communities and
functions in forest ecosystems along a climatic gradient — Zhiwei Xu — Biogeosciences
Analogous methods for targeted manipulation
of microbial species in an ecosystem could play a similarly transformative role in dissecting
microbial function.
Just like we test hypotheses about the
functions of genes in genetic networks by knocking them out and replacing them, we need methods to selectively remove or inhibit specific microbes or metabolisms in
microbial networks to determine their roles,» Brodie added.
He is now a researcher at Florida International University where he will continue to pursue his studies
of the interactions between soft - sediment metazoan and
microbial assemblages and the impact this has on biogeochemical cycling and ecosystem
function.
The focus
of the Kavli Microbiome Ideas Challenge is to develop new tools and methods that specifically catalyze discovery in understanding
microbial function.
«I view the Kavli Microbiome Ideas Challenge as a catalyst, a program that brings new approaches and new people into the field to rapidly increase our understanding
of microbial communities»
functions and mechanisms,» said Tim Donohue, Past President, ASM.
«To move beyond cataloging microbes, we will need new tools to rapidly determine
microbial gene
function and monitor the chemicals microbes use to communicate and interact with their environment, and new ways to visualize and model those interactions,» said Eoin Brodie, a staff scientist at Lawrence Berkeley National Laboratory's Earth Sciences Division and an author
of the proposal.
While science has told us that intestinal microbes in the gut are intimately linked to the cause
of IBD, only a limited number
of these enormously complex
microbial agents have been identified and their
functions have remained largely unknown.
During his post-doctoral years he developed an interest in the contribution
of uncultured microbes to the maintenance and
function of ecosystems i.e. molecular
microbial ecology.
Recent discoveries have revealed that the vast majority
of life on our planet is
microbial; however, still lacking is an understanding
of how microbes
function and the role that specific microbes play in regulating host physiology and health.
The Kavli Microbiome Ideas Challenge aims to spur the development
of new tools and methods that catalyze discovery in understanding
microbial function.
Two very interesting approaches driven by new insights into the microbiome as a whole involve mimicking or modifying these
microbial communities, either by using bugs themselves as drugs, or by developing traditional therapeutics that reproduce the
function of the microbiome.
Microbial ecology, phytoplankton physiology and mortality, virology, molecular evolution and ecology, biogeochemistry, ecosystem processes, the structure and function of microbial f
Microbial ecology, phytoplankton physiology and mortality, virology, molecular evolution and ecology, biogeochemistry, ecosystem processes, the structure and
function of microbial f
microbial food webs.
In the article «Ecological communities by design,» Fredrickson discusses how synthetic ecology — the design and construction
of microbial communities with desirable properties — requires new knowledge on how communities
function.
Attacking this
function, and other mechanisms that promote survival
of the bacteria in the urinary tract, may be a strategy for new
microbial agents, authors say.
Metagenomics is the high - throughput sequencing
of microbial community DNA extracts and, because it directly sequences this DNA, it can be used to characterize changes in the genes themselves and their
function.
Modulation
of the efficiency
of trace metal phytoremediation by Sedum plumbizincicola by
microbial community structure and
function — Jinyu Hou — Plant and Soil
Today, microbes continue to evolve in response to an ever - changing environment, and
microbial ecosystems still govern the biogeochemical cycling
of the planet and profoundly affect the
function of all other living organisms.
Achberger will be continuing the research to sequence the DNA, which will show just what types
of microbial life they found and how each
of these
function in the ecosystem.
Antje Boetius and her team are renowned for their contributions to the diversity and
function of life associated with seafloor processes, including pelagobenthic coupling, gas seepage and fluid flow, and the structure,
function and dynamics
of microbial communities
of the ocean floor.
Studies have shown that vitamin B12 can help improve digestion by contributing to the «structure and
function of human gut
microbial communities» (21.)
The effect
of diet on the gluconeogenic capacity
of rat - kidney - cortex slices [5] Liver and kidney metabolism during prolonged starvation [6] Unrecognized Pandemic «Subclinical» Diabetes
of the Affluent Nations: Causes, Cost and Prevention [7] Carbohydrates and Immune
Function [8] Overexpression
of glut1 and glut3 in stage I nonsmall cell lung carcinoma is Associated with poor survival [9] The in?uence
of diet on the mucin carbohydrates in the chick intestinal tract [10] Rat intestinal mucosal responses to a
microbial flora and different diets [12] Chronic Ethanol Induced Impairment
of Hepatic Glycosylation Machinery in Rat Is Independent
of Dietary Carbohydrate [13] Glycosylation in Cellular Mechanisms
of Health and Disease [14] Metabolic Aberrations Associated with Arginine Deficiency [15] Glycerol gluconeogenesis in fasting humans
Melatonin protects against chemical, free radical,
microbial and heavy metal damage that lead to degeneration
of brain structure and
function.
The same study noted that when your
microbial ecosystem is in a state
of dysbiosis, gut bacteria can produce substances like D - lactic acid and ammonia, which can exert neurotoxic properties and impede the
function of the nervous system.
They also provide a list
of mechanisms for protection from chronic disease that may serve as research targets, including clinical disease, protection from oxidation, improved insulin and fat metabolism, antiinflammatory action, anticlotting action, improved bowel
function and
microbial milieu, stimulation
of protective enzymes, prevention
of DNA damage, and enhancement
of DNA repair.
A gastroenterology research team revealed that certain types
of microbial ecosystems are linked to anxiety and impaired brain
function (17).
``... dietary composition ultimately affects the structure, organization,
function, and speciation
of the human microbiome occupying the GI tract, in part by supplying multiple substrates for
microbial metabolism.
Indeed, scientists still aren't sure exactly which
microbial species are part
of a healthy microbiome, nor do they know whether certain bacterial strains are absolutely vital to mental
functioning, or whether the right balance is what's key.